NSCLC Locally advanced malignant neoplasm | NSCLC Neoplasm metastasis
Item
locally advanced or metastatic nsclc
boolean
C0007131 (UMLS CUI [1,1])
C0677984 (UMLS CUI [1,2])
C0007131 (UMLS CUI [2,1])
C0027627 (UMLS CUI [2,2])
EGFR mutation | EGFR Exon 19 Deletion Mutation | EGFR L858R mutation
Item
egfr mutation (l858r and /or ex19del)
boolean
C3266992 (UMLS CUI [1])
C3274204 (UMLS CUI [2])
C4289657 (UMLS CUI [3])
C-MET gene amplification FISH | c-met gene Copy number
Item
cmet amplification by fish (gcn ≥ 6),
boolean
C1711106 (UMLS CUI [1,1])
C0162789 (UMLS CUI [1,2])
C0072453 (UMLS CUI [2,1])
C1707513 (UMLS CUI [2,2])
Resistance Acquired EGFR TKI Generation
Item
acquired resistance to egfr tki (1st or 2nd génération)
boolean
C0013203 (UMLS CUI [1,1])
C1443775 (UMLS CUI [1,2])
C0439661 (UMLS CUI [1,3])
C0079411 (UMLS CUI [1,4])
ECOG performance status
Item
ecog performance status (ps) ≤ 1.
boolean
C1520224 (UMLS CUI [1])
EGFR-TKI Generation Third Prior treatment
Item
prior treatment with 3rd generation tki
boolean
C1443775 (UMLS CUI [1,1])
C0079411 (UMLS CUI [1,2])
C0205437 (UMLS CUI [1,3])
C1514463 (UMLS CUI [1,4])
Prior therapy with crizotinib, c-met inhibitors, HGF-targeting inhibitors
Item
phaseii : prior treatment with any of the following agents: crizotinib, or any other cmet inhibitor or hgf-targeting inhibitor.
boolean
C2974289 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C1999216 (UMLS CUI [2,1])
C0072453 (UMLS CUI [2,2])
C1514463 (UMLS CUI [2,3])
C1999216 (UMLS CUI [3,1])
C0062534 (UMLS CUI [3,2])
C2985566 (UMLS CUI [3,3])
C1514463 (UMLS CUI [3,4])
Prior concomitant therapy with EGFR-TKI and Platinum-based Chemotherapy | First line treatment
Item
phaseii : prior treatment with any of the following agents: concomitant egfr tki and platinum based chemotherapy as first line regimen.
boolean
C1707479 (UMLS CUI [1,1])
C1443775 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,3])
C1707479 (UMLS CUI [2,1])
C1514162 (UMLS CUI [2,2])
C0392920 (UMLS CUI [2,3])
C1514463 (UMLS CUI [2,4])
C1708063 (UMLS CUI [3])
Prior first line Platinum-Based Chemotherapy
Item
phaseii : prior treatment with any of the following agents: platinum-based chemotherapy as first line treatment
boolean
C1514463 (UMLS CUI [1,1])
C1708063 (UMLS CUI [1,2])
C0392920 (UMLS CUI [1,3])
C1514162 (UMLS CUI [1,4])