Rheumatoid Arthritis Duration Disease activity score das28
Item
active rheumatoid arthritis, characterized by a disease activity score (das28) above 3.2, and a diagnosis of at least three months duration
boolean
C0003873 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C4481729 (UMLS CUI [1,3])
Age
Item
aged between 18 and 75 years (both inclusive)
boolean
C0001779 (UMLS CUI [1])
Methotrexate Dose Stable
Item
subjects on stable doses of methotrexate for at least 4 weeks prior to dosing
boolean
C0025677 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Contraceptive methods
Item
use of highly effective contraception during the trial (both males and females)
boolean
C0700589 (UMLS CUI [1])
Autoimmune Diseases inflammatory chronic | Inflammatory joint disease chronic | Exception Rheumatoid Arthritis
Item
a chronic inflammatory autoimmune or joint disease other than ra (rheumatoid arthritis)
boolean
C0004364 (UMLS CUI [1,1])
C0333348 (UMLS CUI [1,2])
C0205191 (UMLS CUI [1,3])
C0683381 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0003873 (UMLS CUI [3,2])
Tuberculosis | Latent Tuberculosis
Item
an active or latent tuberculosis
boolean
C0041296 (UMLS CUI [1])
C1609538 (UMLS CUI [2])
Therapies, Investigational
Item
any investigational or experimental therapy within 4 weeks or 5 half-lives (whichever is longer) prior to the screening visit
boolean
C0949266 (UMLS CUI [1])
Cardiovascular Disease
Item
a known significant cardio-vascular disease
boolean
C0007222 (UMLS CUI [1])
Vaccination Against Virus | Vaccination Against Bacteria
Item
vaccination against live virus or bacteria within 4 weeks prior to randomization
boolean
C0042196 (UMLS CUI [1,1])
C0521124 (UMLS CUI [1,2])
C0042776 (UMLS CUI [1,3])
C0042196 (UMLS CUI [2,1])
C0521124 (UMLS CUI [2,2])
C0004611 (UMLS CUI [2,3])
Pharmaceutical Preparations Illicit | DMARDs Some | Biological agents Some | Corticoid Intra-Articular Injections
Item
the use of concomitant medications that are prohibited in the trial (e.g., certain dmards (antirheumatic therapies that are disease modifying), biologics (here: biotechnologically produced antibodies), intra-articular corticoid-injections, etc.)
boolean
C0013227 (UMLS CUI [1,1])
C0332266 (UMLS CUI [1,2])
C0242708 (UMLS CUI [2,1])
C0205392 (UMLS CUI [2,2])
C0005515 (UMLS CUI [3,1])
C0205392 (UMLS CUI [3,2])
C0001617 (UMLS CUI [4,1])
C0021488 (UMLS CUI [4,2])
Positive Test Result HIV Infection | Hepatitis B positive | Hepatitis C positive | Tuberculosis skin test Positive
Item
a positive test result for human immunodeficiency virus (hiv) infection, hepatitis b and/or hepatitis c, or tuberculosis skin test
boolean
C1335447 (UMLS CUI [1,1])
C0019693 (UMLS CUI [1,2])
C0856706 (UMLS CUI [2])
C1112419 (UMLS CUI [3])
C0041290 (UMLS CUI [4,1])
C1514241 (UMLS CUI [4,2])
Blood Donation Amount Timespan
Item
donation of greater than or equal to 400 ml of blood within 8 weeks prior to trial entry
boolean
C0005794 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0872291 (UMLS CUI [1,3])