Gender | High risk of Breast Carcinoma
Item
1. women must be at increased risk for breast cancer based on any of the following criteria:
boolean
C0079399 (UMLS CUI [1])
C0332167 (UMLS CUI [2,1])
C0678222 (UMLS CUI [2,2])
Age | Live Birth Previous Absent
Item
age 30 or older with no prior live birth.
boolean
C0001779 (UMLS CUI [1])
C0481667 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Mutations Associated with Hereditary Malignant Neoplasm | BRCA1 gene mutation | BRCA2 gene mutation | TP53 Gene Mutation | PTEN gene mutation
Item
mutations associated with hereditary cancer (brca1 or 2, p53, pten)
boolean
C0026882 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C1333600 (UMLS CUI [1,3])
C1511022 (UMLS CUI [2])
C1511024 (UMLS CUI [3])
C3897380 (UMLS CUI [4])
C3267001 (UMLS CUI [5])
Family history of breast cancer | First Degree Relative Quantity | Second Degree Relative multiple
Item
family history of breast cancer including one first degree or multiple second degree relatives
boolean
C0559119 (UMLS CUI [1])
C1517194 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C1519210 (UMLS CUI [3,1])
C0439064 (UMLS CUI [3,2])
Radiotherapy to thorax Before Age
Item
history of chest radiation before age 30
boolean
C4038705 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Biopsy of breast multiple
Item
multiple prior breast biopsies
boolean
C0405352 (UMLS CUI [1,1])
C0439064 (UMLS CUI [1,2])
Precancerous Conditions | DCIS | LCIS | Atypical hyperplasia
Item
precancerous conditions (dcis, lcis, ah)
boolean
C0032927 (UMLS CUI [1])
C0007124 (UMLS CUI [2])
C0279563 (UMLS CUI [3])
C0333977 (UMLS CUI [4])
Medical History Breast Carcinoma | Medical History Ovarian neoplasm
Item
prior history of breast or ovarian cancer
boolean
C0262926 (UMLS CUI [1,1])
C0678222 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0919267 (UMLS CUI [2,2])
Mammographic Breast Density Estimated
Item
estimated mammographic breast density > 50%
boolean
C1268717 (UMLS CUI [1,1])
C0750572 (UMLS CUI [1,2])
Infertility therapy | Controlled ovarian hyperstimulation
Item
2. must be undergoing infertility treatment at the university of kansas with controlled ovarian hyper-stimulation (coh)
boolean
C0200070 (UMLS CUI [1])
C3160882 (UMLS CUI [2])
Age | Follicle stimulating hormone measurement | Estradiol measurement
Item
3. must be between the ages of 21-45 (both inclusive) with day 3 fsh less than 12 iu/l, day 3 e2 less than 80 pg/ml
boolean
C0001779 (UMLS CUI [1])
C0202022 (UMLS CUI [2])
C0337434 (UMLS CUI [3])
Gender | Age
Item
1. women under 21 or over 45 years old
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Follicle stimulating hormone measurement | Estradiol measurement
Item
2. day 3 fsh over 12 iu/l, day 3 e2 over 80 pg/ml
boolean
C0202022 (UMLS CUI [1])
C0337434 (UMLS CUI [2])
Lacking Risk factors Fulfill
Item
3. women who do not meet risk criteria above
boolean
C0332268 (UMLS CUI [1,1])
C0035648 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
Hypersensitivity Letrozole | Gonadotrophic hormone allergy
Item
4. history of hypersensitivity to letrozole or gonadotropin
boolean
C0020517 (UMLS CUI [1,1])
C0246421 (UMLS CUI [1,2])
C0571726 (UMLS CUI [2])
Uterine Diseases | Adnexal Diseases
Item
5. uterine and adnexal pathology
boolean
C0042131 (UMLS CUI [1])
C0001576 (UMLS CUI [2])
Clomid | Gonadotropin
Item
6. use of clomid or gonadotropin within 30days before the letrozole cycle
boolean
C0591268 (UMLS CUI [1])
C0018061 (UMLS CUI [2])
Chronic disease Severe | Relevance Reproductive function
Item
7. any severe chronic disease of relevance for reproductive function
boolean
C0008679 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C2347946 (UMLS CUI [2,1])
C0232896 (UMLS CUI [2,2])