Indolent Non-Hodgkin Lymphoma progressed
Item
subjects who have been diagnosed with indolent nhl that has progressed.
boolean
C1334170 (UMLS CUI [1,1])
C1272688 (UMLS CUI [1,2])
Complete remission Lacking | Partial response Lacking | Disease Progression | Status post Induction Chemotherapy | Status post Radioimmunotherapy
Item
subjects must have exhibited lack of cr or pr or progression within 6 months after the last dose of a chemotherapy induction regimen or rit.
boolean
C0677874 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
C1521726 (UMLS CUI [2,1])
C0332268 (UMLS CUI [2,2])
C0242656 (UMLS CUI [3])
C0231290 (UMLS CUI [4,1])
C3179010 (UMLS CUI [4,2])
C0231290 (UMLS CUI [5,1])
C0085101 (UMLS CUI [5,2])
Disease Unresponsive to Rituximab | Complete remission Lacking | Partial response Lacking | Progressive Disease
Item
subjects must have rituximab-refractory disease, defined as lack of cr or pr or pd within 6 months of last dose.
boolean
C0012634 (UMLS CUI [1,1])
C0205269 (UMLS CUI [1,2])
C0393022 (UMLS CUI [1,3])
C0677874 (UMLS CUI [2,1])
C0332268 (UMLS CUI [2,2])
C1521726 (UMLS CUI [3,1])
C0332268 (UMLS CUI [3,2])
C1335499 (UMLS CUI [4])
Measurable Disease CT | Measurable Disease PET/CT | Measurable Disease MRI | Nodal mass Size | Tumor Mass Size
Item
measurable disease with a lymph node or tumor mass ≥1.5 cm in at least one dimension by ct, pet/ct or mri.
boolean
C1513041 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C1699633 (UMLS CUI [2,2])
C1513041 (UMLS CUI [3,1])
C0024485 (UMLS CUI [3,2])
C0746921 (UMLS CUI [4,1])
C0456389 (UMLS CUI [4,2])
C3273930 (UMLS CUI [5,1])
C0456389 (UMLS CUI [5,2])
Renal function | Liver function
Item
adequate renal and hepatic function.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
Patient Appropriate Curative treatment
Item
candidate for potentially curative therapies in the opinion of the investigator.
boolean
C0030705 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C1273390 (UMLS CUI [1,3])
PI3K Inhibitor | BTK Inhibitor
Item
previous treatment with a pi3k inhibitor or btk inhibitor.
boolean
C1519050 (UMLS CUI [1])
C0218158 (UMLS CUI [2,1])
C1999216 (UMLS CUI [2,2])
Allogeneic Hematopoietic Stem Cell Transplantation
Item
prior history of allogeneic hematopoietic stem cell transplant (hsct).
boolean
C1705576 (UMLS CUI [1])
Prior Chemotherapy | Therapeutic immunosuppression Malignant Neoplasms | Investigational New Drugs
Item
prior chemotherapy, cancer immunosuppressive therapy, or other investigational agents within 4 weeks before first dose of study drug.
boolean
C1514457 (UMLS CUI [1])
C0021079 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
C0013230 (UMLS CUI [3])
Follicular Lymphoma Grade | Transformation Aggressive Lymphoma
Item
grade 3b fl and/or clinical evidence of transformation to a more aggressive subtype of lymphoma.
boolean
C0024301 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
C0040682 (UMLS CUI [2,1])
C1332225 (UMLS CUI [2,2])
CNS lymphoma Symptomatic
Item
symptomatic central nervous system (cns) nhl.
boolean
C0280803 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Systemic bacterial infection | Systemic mycosis | Systemic viral infection
Item
ongoing systemic bacterial, fungal, or viral infections at the time of initiation of study treatment.
boolean
C4285778 (UMLS CUI [1])
C0553576 (UMLS CUI [2])
C4285789 (UMLS CUI [3])
Hepatitis B | Hepatitis C | Hepatitis B, Chronic | Hepatitis C, Chronic | Hepatitis C antibody positive | Hepatitis B surface antigen positive | Hepatitis B core antibody positive
Item
prior, current, or chronic hepatitis b or hepatitis c infection, positive result for hepatitis c virus antibodies (hcv ab) or hepatitis b surface antigen (hbsag) or hepatitis b core antibodies (hbcab)
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0524909 (UMLS CUI [3])
C0524910 (UMLS CUI [4])
C0281863 (UMLS CUI [5])
C0149709 (UMLS CUI [6])
C0262506 (UMLS CUI [7])
Cerebrovascular accident | Angina, Unstable | Myocardial Infarction | Ventricular arrhythmia Requirement Pharmaceutical Preparations | Ventricular arrhythmia Requirement Control
Item
history of stroke, unstable angina, myocardial infarction, or ventricular arrhythmia requiring medication or mechanical control within the last 6 months prior to first dose of study drug
boolean
C0038454 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0085612 (UMLS CUI [4,1])
C1514873 (UMLS CUI [4,2])
C0013227 (UMLS CUI [4,3])
C0085612 (UMLS CUI [5,1])
C1514873 (UMLS CUI [5,2])
C2587213 (UMLS CUI [5,3])