Age | Colorectal cancer metastatic
Item
1. patients aged ≥18 years with histologically confirmed metastatic colorectal cancer
boolean
C0001779 (UMLS CUI [1])
C0948380 (UMLS CUI [2])
ECOG performance status
Item
2. eastern cooperative oncology group performance status ≤2 and
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
3. life expectancy of >3 months were enrolled.
boolean
C0023671 (UMLS CUI [1])
Measurable lesion Quantity
Item
4. all patients had to have at least one measurable lesion according to the response evaluation criteria in solid tumors (recist, version 1.1)
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Absence Exposure to Cetuximab | Absence Exposure to Irinotecan
Item
5. none was previous exposure to cetuximab or irinotecan .
boolean
C0332197 (UMLS CUI [1,1])
C0332157 (UMLS CUI [1,2])
C0995188 (UMLS CUI [1,3])
C0332197 (UMLS CUI [2,1])
C0332157 (UMLS CUI [2,2])
C0123931 (UMLS CUI [2,3])
Hematologic function | Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement | Liver function | Serum total bilirubin measurement
Item
6. patients had to have adequate haematological (absolute neutrophil count >1.5 × 109/l; platelet count >100 × 109/l; haemoglobin >9 g/dl), hepatic [total bilirubin <1.5 ×
boolean
C0221130 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
C0232741 (UMLS CUI [5])
C1278039 (UMLS CUI [6])
Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Secondary malignant neoplasm of liver | Secondary malignant neoplasm of bone
Item
the upper limit of normal (uln); alanine aminotransferase and aspartate aminotransferase <2.5 × uln, or <5 × uln in the case of hepatic metastases or <10 ×
boolean
C0201836 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0494165 (UMLS CUI [3])
C0153690 (UMLS CUI [4])
Alkaline phosphatase measurement | Secondary malignant neoplasm of liver | Secondary malignant neoplasm of bone | Renal function | Creatinine clearance measurement
Item
uln in the case of osseous metastases; alkaline phosphatase <2.5 × uln, or <5 × uln or <10 × uln in the case of hepatic or osseous metastases, respectively] and renal function (creatinine clearance ≥60 ml/min)
boolean
C0201850 (UMLS CUI [1])
C0494165 (UMLS CUI [2])
C0153690 (UMLS CUI [3])
C0232804 (UMLS CUI [4])
C0373595 (UMLS CUI [5])
RAS Wild Type
Item
7. all ras were wildtype. -
boolean
C4331207 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
1. pregnant or breast-feeding women;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Heart Disease
Item
2. clinically significant cardiac disease;
boolean
C0018799 (UMLS CUI [1])
Upper gastrointestinal tract | Integrity Physical Lacking
Item
3. lack of physical integrity of the upper gastrointestinal tract;
boolean
C1268997 (UMLS CUI [1])
C1947912 (UMLS CUI [2,1])
C0205485 (UMLS CUI [2,2])
C0332268 (UMLS CUI [2,3])
Cancer Other
Item
4. history of other malignancy;
boolean
C1707251 (UMLS CUI [1])
CNS metastases
Item
5. central nervous system metastases. -
boolean
C0686377 (UMLS CUI [1])