Gender | Pseudotumor Cerebri Duration | Age | Papilledema Grade | Raised intracranial pressure | Thrombosis of venous sinuses Absent Magnetic Resonance Imaging | Thrombosis of venous sinuses Absent Computed Tomography | Thrombosis of venous sinuses Absent Venography
Item
1. female iih patients aged between 18 and 55 years, diagnosed according to the modified dandy criteria who have chronic (> 6 months duration), active disease (papilloedema [frisen grade ≥ 1], significantly raised icp > 25cmh2o) and no evidence of venous sinus thrombosis (magnetic resonance or ct imaging and venography as noted at diagnosis).
boolean
C0079399 (UMLS CUI [1])
C0033845 (UMLS CUI [2,1])
C0449238 (UMLS CUI [2,2])
C0001779 (UMLS CUI [3])
C0030353 (UMLS CUI [4,1])
C0441800 (UMLS CUI [4,2])
C0437215 (UMLS CUI [5])
C0740384 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0024485 (UMLS CUI [6,3])
C0740384 (UMLS CUI [7,1])
C0332197 (UMLS CUI [7,2])
C0040405 (UMLS CUI [7,3])
C0740384 (UMLS CUI [8,1])
C0332197 (UMLS CUI [8,2])
C0031545 (UMLS CUI [8,3])
Body mass index
Item
2. bmi >35kg/m2.
boolean
C1305855 (UMLS CUI [1])
Weight reduction regimen failed
Item
3. tried other appropriate non-surgical treatments to lose weight but have not been able to achieve or maintain adequate, clinically beneficial weight loss for at least 6 months.
boolean
C0311130 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])
Informed Consent
Item
4. able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Age
Item
1. age less than 18 or older than 55 years.
boolean
C0001779 (UMLS CUI [1])
Pregnancy | Pregnancy, Planned
Item
2. pregnant or planning to conceive during the first 18 months of the trial .
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
Comorbidity | Endocrine System Diseases | Hormone Modulating Pharmaceutical Preparations | Exception Contraceptive methods | Exception Topical steroids | Exception Inhaled steroids
Item
3. significant co-morbidity, endocrinopathy or the use of hormone manipulating medication (excluding contraception and topical or inhaled steroids).
boolean
C0009488 (UMLS CUI [1])
C0014130 (UMLS CUI [2])
C0019932 (UMLS CUI [3,1])
C0443264 (UMLS CUI [3,2])
C0013227 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C2064827 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C2065041 (UMLS CUI [6,2])
Optic nerve sheath Fenestration
Item
4. undergone optic nerve sheath fenestration.
boolean
C0228673 (UMLS CUI [1,1])
C0337280 (UMLS CUI [1,2])
Indication Operative Surgical Procedures | Medical contraindication Operative Surgical Procedures | Indication Dieting | Medical contraindication Dieting
Item
5. definite indication for or contraindication against surgery or dieting.
boolean
C3146298 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0543467 (UMLS CUI [2,2])
C3146298 (UMLS CUI [3,1])
C2945766 (UMLS CUI [3,2])
C1301624 (UMLS CUI [4,1])
C2945766 (UMLS CUI [4,2])
Medical contraindication Operative Surgical Procedures | Drug abuse | Eating Disorders | Major Depressive Disorder | Feeling suicidal | Drug Overdose | Patient Admission Psychological
Item
6. have a specific medical or psychiatric contraindication for surgery, including drug misuse, eating disorder or major depression (suicidal ideation, drug overdose or psychological admission in last 12 months).
boolean
C1301624 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C0013146 (UMLS CUI [2])
C0013473 (UMLS CUI [3])
C1269683 (UMLS CUI [4])
C0424000 (UMLS CUI [5])
C0029944 (UMLS CUI [6])
C0030673 (UMLS CUI [7,1])
C0205486 (UMLS CUI [7,2])
Bariatric Surgery
Item
7. previous bariatric surgery.
boolean
C1456587 (UMLS CUI [1])
AZD4017
Item
8. taken azd4017 within the last four months .
boolean
C3501337 (UMLS CUI [1])
Informed Consent Unable | Etiology Impaired cognition
Item
9. inability to give informed consent e.g. due to cognitive impairment.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0015127 (UMLS CUI [2,1])
C0338656 (UMLS CUI [2,2])