Age
Item
age > 18 years.
boolean
C0001779 (UMLS CUI [1])
Hypertensive disease Stage | Systolic Pressure | Diastolic blood pressure | Therapy Stable
Item
subjects with stage 1 hypertension (sbp: 140-159 mm hg or dbp 90-99 mm hg) if on therapy, it must be stable for at least 1 month.
boolean
C0020538 (UMLS CUI [1,1])
C0699749 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
C0087111 (UMLS CUI [4,1])
C0205360 (UMLS CUI [4,2])
Congestive heart failure New York Heart Association Classification
Item
congestive heart failure (any nyha class).
boolean
C0018802 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Cardiac ejection fraction
Item
ef < 50%.
boolean
C0232174 (UMLS CUI [1])
Myocardial Infarction
Item
myocardial infarction within 3 months of screening.
boolean
C0027051 (UMLS CUI [1])
Angina, Unstable | Myocardial Ischemia
Item
unstable angina within 14 days of screening, or any evidence of myocardial ischemia.
boolean
C0002965 (UMLS CUI [1])
C0151744 (UMLS CUI [2])
Pulmonary Hypertension Moderate | Pulmonary Hypertension Severe
Item
moderate to severe pulmonary hypertension.
boolean
C0020542 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0020542 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Valvular stenosis | Hypertrophic Cardiomyopathy | Restrictive cardiomyopathy | Pericarditis, Constrictive | Idiopathic pulmonary hypertension | Myocarditis
Item
valvular stenosis, hypertrophic, restrictive or obstructive cardiomyopathy, constrictive pericarditis, primary pulmonary hypertension, or biopsy proven active myocarditis.
boolean
C1883524 (UMLS CUI [1])
C0007194 (UMLS CUI [2])
C0007196 (UMLS CUI [3])
C0031048 (UMLS CUI [4])
C0152171 (UMLS CUI [5])
C0027059 (UMLS CUI [6])
Sustained ventricular tachycardia | Sustained ventricular fibrillation
Item
sustained vt or v-fib within 14 days of screening.
boolean
C0750197 (UMLS CUI [1])
C1998349 (UMLS CUI [2])
Persistent atrial fibrillation
Item
sustained atrial fibrillation.
boolean
C2585653 (UMLS CUI [1])
Second degree atrioventricular block | Complete atrioventricular block | Permanent cardiac pacemaker Absent
Item
second or third degree av block without a permanent cardiac pacemaker.
boolean
C0264906 (UMLS CUI [1])
C0151517 (UMLS CUI [2])
C1828453 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Cerebrovascular accident | Other Coding
Item
cva within 3 months of screening, or other evidence of significantly compromised cns perfusion.
boolean
C0038454 (UMLS CUI [1])
C3846158 (UMLS CUI [2])
Serum total bilirubin measurement | Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
total bilirubin of >1.5 mg/dl or ast and alt 1.5 times the upper limit of normal range.
boolean
C1278039 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
Renal Insufficiency | Glomerular Filtration Rate Cockcroft-Gault formula
Item
renal insufficiency assessed by calculated gfr < 60 ml/min (cockroft-gault equation).
boolean
C1565489 (UMLS CUI [1])
C0017654 (UMLS CUI [2,1])
C2924627 (UMLS CUI [2,2])
Serum sodium measurement
Item
serum sodium of < 125 meq/dl or > 160 meq/dl.
boolean
C0523891 (UMLS CUI [1])
Serum potassium measurement
Item
serum potassium of < 3.5 meq/dl or > 5.0 meq/dl.
boolean
C0302353 (UMLS CUI [1])
Gender | Contraceptives, Oral, Hormonal
Item
women taking hormonal contraceptives.
boolean
C0079399 (UMLS CUI [1])
C0009907 (UMLS CUI [2])
Body mass index
Item
body mass index (bmi) > 35.
boolean
C1305855 (UMLS CUI [1])