Creatinine clearance measurement | Variation Percentage Recent
Item
creatinine clearance 30 to 90 ml/min/1.73 m2, with variations of less than 20 percent in the 2 weeks before the screening evaluation.
boolean
C0373595 (UMLS CUI [1])
C0205419 (UMLS CUI [2,1])
C0439165 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
Hypertensive disease | Antihypertensive Agents
Item
diagnosed hypertension according to guidelines or having taken anti-hypertension drugs.
boolean
C0020538 (UMLS CUI [1])
C0003364 (UMLS CUI [2])
Age
Item
aged between 65 and 85 years.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
willingness to provide written, informed consent.
boolean
C0021430 (UMLS CUI [1])
Protocol Compliance
Item
ability to adhere to study protocol.
boolean
C0525058 (UMLS CUI [1])
Secondary hypertension
Item
secondary hypertension.
boolean
C0155616 (UMLS CUI [1])
Diabetes Mellitus
Item
diabetes mellitus.
boolean
C0011849 (UMLS CUI [1])
Atrial Flutter | Atrial Fibrillation
Item
atrial flutter/atrial fibrillation.
boolean
C0004239 (UMLS CUI [1])
C0004238 (UMLS CUI [2])
Symptoms Congestive heart failure New York Heart Association Classification | Left ventricular ejection fraction
Item
symptoms of congestive heart failure (nyha iii-iv) or there is evidence that left ventricular ef < 40%.
boolean
C1457887 (UMLS CUI [1,1])
C0018802 (UMLS CUI [1,2])
C1275491 (UMLS CUI [1,3])
C0428772 (UMLS CUI [2])
Myocardial Infarction Recent | Symptoms Cerebral Ischemia
Item
recent (< 6 months) myocardial infarction or cerebrovascular ischemic symptoms.
boolean
C0027051 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C1457887 (UMLS CUI [2,1])
C0917798 (UMLS CUI [2,2])
Coronary revascularisation Recent | Coronary revascularisation Planned | Percutaneous Coronary Intervention | Coronary Artery Bypass Surgery
Item
recent (< 3 months) or planned coronary revascularization: pci (percutaneous coronary intervention)/cabg (coronary artery by-pass graft).
boolean
C0877341 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C0877341 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
C1532338 (UMLS CUI [3])
C0010055 (UMLS CUI [4])
Heart valve disease Severe
Item
severe valvular heart disease.
boolean
C0018824 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Indapamide allergy | Allergy to thiazides | Hypersensitivity Component Indapamide | Hypersensitivity Component Thiazide
Item
history of hypersensitivity to indapamide, thiazides or to any of the components of the products.
boolean
C0571927 (UMLS CUI [1])
C0749320 (UMLS CUI [2])
C0020517 (UMLS CUI [3,1])
C1705248 (UMLS CUI [3,2])
C0021186 (UMLS CUI [3,3])
C0020517 (UMLS CUI [4,1])
C1705248 (UMLS CUI [4,2])
C0541746 (UMLS CUI [4,3])
Condition Interferes with Absorption Investigational New Drugs | Disease Interferes with Absorption Investigational New Drugs | Condition Interferes with Distribution Investigational New Drugs | Disease Interferes with Distribution Investigational New Drugs | Condition Interferes with Metabolism Investigational New Drugs | Disease Interferes with Metabolism Investigational New Drugs | Condition Interferes with Excretion Investigational New Drugs | Disease Interferes with Excretion Investigational New Drugs
Item
any current condition or other disease known to interfere significantly with the absorption, distribution, metabolism or excretion of study drugs.
boolean
C0348080 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0237442 (UMLS CUI [1,3])
C0013230 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C0013230 (UMLS CUI [2,4])
C0348080 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C1378698 (UMLS CUI [3,3])
C0013230 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C1378698 (UMLS CUI [4,3])
C0013230 (UMLS CUI [4,4])
C0348080 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0025519 (UMLS CUI [5,3])
C0013230 (UMLS CUI [5,4])
C0012634 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0025519 (UMLS CUI [6,3])
C0013230 (UMLS CUI [6,4])
C0348080 (UMLS CUI [7,1])
C0521102 (UMLS CUI [7,2])
C0221102 (UMLS CUI [7,3])
C0013230 (UMLS CUI [7,4])
C0012634 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C0221102 (UMLS CUI [8,3])
C0013230 (UMLS CUI [8,4])
Study Subject Participation Status | Research study
Item
participation to another investigational study in the last 3 months.
boolean
C2348568 (UMLS CUI [1])
C0681814 (UMLS CUI [2])