Adult | Age
Item
adult patients, >/= 18 years of age
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Chronic Hepatitis C Genotype
Item
chronic hepatitis c, genotype 1
boolean
C0524910 (UMLS CUI [1,1])
C1533728 (UMLS CUI [1,2])
Therapy naive | Recurrent disease | Unresponsive to Combination therapy Interferon Ribavirin
Item
treatment-naïve or patients who relapsed or failed to respond to previous combination therapy with interferon and ribavirin
boolean
C0919936 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
C0205269 (UMLS CUI [3,1])
C0009429 (UMLS CUI [3,2])
C3652465 (UMLS CUI [3,3])
C0035525 (UMLS CUI [3,4])
Hepatitis C virus RNA Detectable
Item
detectable hcv-rna
boolean
C0369335 (UMLS CUI [1,1])
C3830527 (UMLS CUI [1,2])
Females & males of reproductive potential Contraceptive methods Quantity
Item
fertile males and females of child-bearing potential must agree to use two forms of contraception during treatment and for 6 months after treatment end
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Pregnancy | Breast Feeding
Item
pregnant or breast-feeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Gender Partner Pregnancy
Item
male partners of pregnant women
boolean
C0079399 (UMLS CUI [1,1])
C0682323 (UMLS CUI [1,2])
C0032961 (UMLS CUI [1,3])
Medical condition Associated with Chronic liver disease | Exception Hepatitis C
Item
history or evidence of a medical condition associated with chronic liver disease other than hcv
boolean
C3843040 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C0341439 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0019196 (UMLS CUI [2,2])
Coinfection Hepatitis A | HBV coinfection | HIV coinfection
Item
co-infection with active hepatitis a, hepatitis b and/or hiv virus
boolean
C0275524 (UMLS CUI [1,1])
C0019159 (UMLS CUI [1,2])
C2242656 (UMLS CUI [2])
C4062778 (UMLS CUI [3])
Liver carcinoma
Item
hepatocellular carcinoma
boolean
C2239176 (UMLS CUI [1])
Esophageal Varices | Condition Consistent with Decompensated liver disease
Item
history or evidence of oesophageal varices or other conditions consistent with decompensated liver disease
boolean
C0014867 (UMLS CUI [1])
C0348080 (UMLS CUI [2,1])
C0332290 (UMLS CUI [2,2])
C4075847 (UMLS CUI [2,3])
Anemia
Item
anemia
boolean
C0002871 (UMLS CUI [1])
High risk of Anemia | Thalassemia | Spherocytosis | Gastrointestinal Hemorrhage
Item
any patient with increased baseline risk for anemia (e.g. thalassemia, spherocyctosis, history of gi bleeding)
boolean
C0332167 (UMLS CUI [1,1])
C0002871 (UMLS CUI [1,2])
C0039730 (UMLS CUI [2])
C0553720 (UMLS CUI [3])
C0017181 (UMLS CUI [4])
Cardiovascular Disease
Item
history or evidence of significant cardiovascular disease
boolean
C0007222 (UMLS CUI [1])
Kidney Disease
Item
kidney disease
boolean
C0022658 (UMLS CUI [1])
Retinal Disease Severe
Item
severe retinopathy
boolean
C0035309 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Mental Disorders, Severe | Severe depression
Item
history of severe psychiatric disease, especially depression
boolean
C4046029 (UMLS CUI [1])
C0588008 (UMLS CUI [2])
Antiviral Therapy Systemic | Antineoplastic Agents Systemic | Immunomodulatory therapy Systemic | Steroid therapy High dose | Therapeutic radiology procedure
Item
therapy with any systemic anti-viral, anti-neoplastic or immunomodulatory treatment (including supraphysiologic doses of steroids and radiation) </= 6 months prior to first dose of study drug
boolean
C0280274 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0003392 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
C1963758 (UMLS CUI [3,1])
C0205373 (UMLS CUI [3,2])
C0149783 (UMLS CUI [4,1])
C0444956 (UMLS CUI [4,2])
C1522449 (UMLS CUI [5])