Hepatitis C, Chronic | Hepatitis C virus RNA assay
Item
chronic infection with hepatitis c with hcv rna > 1000 iu/ml
boolean
C0524910 (UMLS CUI [1])
C1272251 (UMLS CUI [2])
Liver Cirrhosis | Child-Pugh - Total Score
Item
individuals with cirrhosis with child-pugh score < 10
boolean
C0023890 (UMLS CUI [1])
C4055253 (UMLS CUI [2])
Esophageal Varices Endoscopy | Gastric Varices Endoscopy
Item
esophageal or gastric varices on endoscopy within 6 months prior to or at screening
boolean
C0014867 (UMLS CUI [1,1])
C0014245 (UMLS CUI [1,2])
C0017145 (UMLS CUI [2,1])
C0014245 (UMLS CUI [2,2])
Hepatic venous pressure gradient
Item
hepatic venous pressure gradient (hvpg) > 6 mmhg
boolean
C4049263 (UMLS CUI [1])
Body mass index
Item
body mass index (bmi) ≥ 18 kg/m^2
boolean
C1305855 (UMLS CUI [1])
Nucleotides Absent Chronic Hepatitis C | Nucleosides Absent Chronic Hepatitis C
Item
naïve to all nucleotides/nucleoside treatments for chronic hcv infection
boolean
C0028630 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0524910 (UMLS CUI [1,3])
C0028621 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0524910 (UMLS CUI [2,3])
Illness Serious Interferes with Therapeutic procedure | Illness Interferes with Therapeutic procedure | Serious mental illness Interferes with Therapeutic procedure | Mental disorder Interferes with Therapeutic procedure | Illness Serious Interferes with Assessment | Illness Interferes with Assessment | Serious mental illness Interferes with Assessment | Mental disorder Interferes with Assessment | Illness Serious Interferes with Compliance | Illness Interferes with Compliance | Serious mental illness Interferes with Compliance | Mental disorder Interferes with Compliance
Item
have any serious or active medical or psychiatric illness which, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
C0221423 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C3841614 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0087111 (UMLS CUI [4,3])
C0221423 (UMLS CUI [5,1])
C0205404 (UMLS CUI [5,2])
C0521102 (UMLS CUI [5,3])
C1516048 (UMLS CUI [5,4])
C0221423 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C1516048 (UMLS CUI [6,3])
C3841614 (UMLS CUI [7,1])
C0521102 (UMLS CUI [7,2])
C1516048 (UMLS CUI [7,3])
C0004936 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C1516048 (UMLS CUI [8,3])
C0221423 (UMLS CUI [9,1])
C0205404 (UMLS CUI [9,2])
C0521102 (UMLS CUI [9,3])
C1321605 (UMLS CUI [9,4])
C0221423 (UMLS CUI [10,1])
C0521102 (UMLS CUI [10,2])
C1321605 (UMLS CUI [10,3])
C3841614 (UMLS CUI [11,1])
C0521102 (UMLS CUI [11,2])
C1321605 (UMLS CUI [11,3])
C0004936 (UMLS CUI [12,1])
C0521102 (UMLS CUI [12,2])
C1321605 (UMLS CUI [12,3])
HIV Infection | Hepatitis B, Chronic | Hepatitis B surface antigen positive
Item
hiv or chronic hepatitis b virus (hbv) infection (hbsag positive)
boolean
C0019693 (UMLS CUI [1])
C0524909 (UMLS CUI [2])
C0149709 (UMLS CUI [3])
Alpha one fetoprotein measurement | Exception Liver mass Imaging Negative
Item
alpha-fetoprotein (afp) > 50 unless negative imaging for hepatic masses within the last 6 months or during screening
boolean
C0201539 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0240225 (UMLS CUI [2,2])
C0011923 (UMLS CUI [2,3])
C1513916 (UMLS CUI [2,4])
Refractory ascites | Requirement Paracentesis times per month
Item
refractory ascites as defined by requiring paracentesis > twice within 1 month prior to screening
boolean
C3532188 (UMLS CUI [1])
C1514873 (UMLS CUI [2,1])
C0034115 (UMLS CUI [2,2])
C0556969 (UMLS CUI [2,3])
Bleeding varices
Item
active variceal bleeding within 6 months of screening
boolean
C0333106 (UMLS CUI [1])
Life Expectancy
Item
expected survival of < 1 year
boolean
C0023671 (UMLS CUI [1])
Hepatorenal Syndrome | Hepatopulmonary Syndrome
Item
history of hepatorenal, or hepatopulmonary syndrome.
boolean
C0019212 (UMLS CUI [1])
C0600452 (UMLS CUI [2])
Renal Insufficiency | Creatinine clearance measurement
Item
evidence of renal impairment (crcl < 50 ml/min)
boolean
C1565489 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Transplantation Organ Major | Transplantation of liver
Item
history of major organ transplantation, including liver transplant.
boolean
C0040732 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0023911 (UMLS CUI [2])