Chronic Hepatitis C Genotype | IL28B gene associated variant rs12979860
Item
chronic hepatitis c, genotype 1 infection with interleukin 28b (il28b) rs12979860 genotype c/c.
boolean
C0524910 (UMLS CUI [1,1])
C1533728 (UMLS CUI [1,2])
C3476056 (UMLS CUI [2])
Biopsy of liver | Histology Consistent with Hepatitis C virus
Item
liver biopsy within 3 years with histology consistent with hepatitis c virus (hcv) -
boolean
C0193388 (UMLS CUI [1])
C0344441 (UMLS CUI [2,1])
C0332290 (UMLS CUI [2,2])
C0220847 (UMLS CUI [2,3])
Liver damage Induced | Liver Cirrhosis Absent | Liver disease Absent | Etiology Except Chronic Hepatitis C
Item
induced liver damage, with no evidence of cirrhosis or liver pathology due to any cause other than chronic hcv.
boolean
C0151763 (UMLS CUI [1,1])
C0205263 (UMLS CUI [1,2])
C0023890 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0023895 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0015127 (UMLS CUI [4,1])
C0332300 (UMLS CUI [4,2])
C0524910 (UMLS CUI [4,3])
Therapy naive | Age
Item
treatment naïve male or female between the ages of 18 and 65.
boolean
C0919936 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Postmenopausal state Duration | Female Sterilization
Item
females must be postmenopausal for at least 2 years or surgically sterile.
boolean
C0232970 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0015787 (UMLS CUI [2])
General health good | Exception Hepatitis C
Item
be in a condition of general good health, as perceived by the investigator, other than hepatitis c virus infection.
boolean
C1277245 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0019196 (UMLS CUI [2,2])
Body mass index
Item
body mass index 18 to < 35 kg/m^2 .
boolean
C1305855 (UMLS CUI [1])
Drug Allergy
Item
significant sensitivity to any drug.
boolean
C0013182 (UMLS CUI [1])
Herbal Supplements
Item
use of herbal supplements within 2 weeks prior to study drug dosing.
boolean
C1504473 (UMLS CUI [1])
Drug screen positive | Blood alcohol test positive
Item
positive screen for certain drugs or alcohol.
boolean
C0743295 (UMLS CUI [1])
C0948726 (UMLS CUI [2])
Hepatitis B surface antigen positive | HIV antibody positive
Item
positive hepatitis b surface antigen or anti-human immunodeficiency virus (hiv) antibody.
boolean
C0149709 (UMLS CUI [1])
C0920548 (UMLS CUI [2])
CYP3A Inducers Strong | CYP2C8 Inducers Strong | OATP1B1 Enzyme Inducers Strong | CYP3A Inhibitors Strong | CYP2C8 Inhibitors Strong | Organic Anion Transporting Polypeptide 1B1 Inhibitors Strong
Item
use of strong cytochrome p450 3a (cyp3a), cytochrome p450 2c8 (cyp2c8), and organic anion transporting polypeptide 1b1 (oatp1b1) enzyme inducers or inhibitors within 1 month of dosing.
boolean
C3850044 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C3850048 (UMLS CUI [2,1])
C0442821 (UMLS CUI [2,2])
C1420131 (UMLS CUI [3,1])
C3819045 (UMLS CUI [3,2])
C0442821 (UMLS CUI [3,3])
C3850056 (UMLS CUI [4,1])
C0442821 (UMLS CUI [4,2])
C3850061 (UMLS CUI [5,1])
C0442821 (UMLS CUI [5,2])
C3819042 (UMLS CUI [6,1])
C0442821 (UMLS CUI [6,2])
Anti-hepatitis C (HCV) Agents Investigational | Anti-hepatitis C (HCV) Agents
Item
prior treatment with any investigational or commercially available anti-hepatitis c virus agents.
boolean
C4324240 (UMLS CUI [1,1])
C1517586 (UMLS CUI [1,2])
C4324240 (UMLS CUI [2])
Laboratory test result abnormal
Item
abnormal laboratory tests.
boolean
C0438215 (UMLS CUI [1])
Liver Cirrhosis | Bridging fibrosis Extensive
Item
cirrhosis or extensive bridging fibrosis.
boolean
C0023890 (UMLS CUI [1])
C0334160 (UMLS CUI [2,1])
C0205231 (UMLS CUI [2,2])
Heart Disease
Item
history of cardiac disease.
boolean
C0018799 (UMLS CUI [1])