Age
Item
1. age ≥ 18 years.
boolean
C0001779 (UMLS CUI [1])
Follicular Lymphoma CD20 antigen positive Ann Arbor lymphoma staging system | Biopsy of lymph node | Biopsy tissue
Item
2. patients with follicular lymphoma grade 1, 2 or 3a, cd20 +, histologically confirmed lymph node biopsy or tissue.
boolean
C0024301 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
C0432516 (UMLS CUI [1,3])
C0193842 (UMLS CUI [2])
C3864006 (UMLS CUI [3])
Lymphoma, Follicular | Combined Modality Therapy | rituximab | Chemotherapy | R-CHOP Regimen | R-CVP Regimen | Rituximab-Fludarabine Regimen | Rituximab Maintenance | Unresponsive to First line treatment | Exception Therapeutic radiology procedure | Recurrent disease | Status post Response Prior Therapy
Item
3. follicular lymphoma patients previously treated with the combination of rituximab and chemotherapy (r-chop, r-cvp, r-fludarabine), having received rituximab maintenance, refractory to a first line (excluding radiotherapy) or relapsed after having achieved any response to previous treatment.
boolean
C0024301 (UMLS CUI [1])
C0009429 (UMLS CUI [2])
C0393022 (UMLS CUI [3])
C3665472 (UMLS CUI [4])
C0393023 (UMLS CUI [5])
C1882520 (UMLS CUI [6])
C1882526 (UMLS CUI [7])
C0393022 (UMLS CUI [8,1])
C0024501 (UMLS CUI [8,2])
C0205269 (UMLS CUI [9,1])
C1708063 (UMLS CUI [9,2])
C1705847 (UMLS CUI [10,1])
C1522449 (UMLS CUI [10,2])
C0277556 (UMLS CUI [11])
C0231290 (UMLS CUI [12,1])
C1704632 (UMLS CUI [12,2])
C1514463 (UMLS CUI [12,3])
ECOG performance status
Item
4. ecog ≤ 2.
boolean
C1520224 (UMLS CUI [1])
Informed Consent
Item
5. signed written informed consent
boolean
C0021430 (UMLS CUI [1])
Suspicion Transformation Histological | Transformation Histological
Item
1. clinical suspicion or documentation of histological transformation.
boolean
C0242114 (UMLS CUI [1,1])
C0040682 (UMLS CUI [1,2])
C0205462 (UMLS CUI [1,3])
C0040682 (UMLS CUI [2,1])
C0205462 (UMLS CUI [2,2])
Hypersensitivity Rituximab
Item
2. patients with hypersensitivity to rituximab.
boolean
C0020517 (UMLS CUI [1,1])
C0393022 (UMLS CUI [1,2])
Transplantation, Autologous | Transplantation, Homologous
Item
3. prior autologous or allogeneic transplant.
boolean
C0040736 (UMLS CUI [1])
C0040739 (UMLS CUI [2])
Central Nervous System Infiltration Follicular Lymphoma | Primary central nervous system lymphoma | Meningeal Carcinomatosis
Item
4. cns infiltration by lf (primary cns lymphoma or lymphomatous meningitis).
boolean
C3714787 (UMLS CUI [1,1])
C0332448 (UMLS CUI [1,2])
C0024301 (UMLS CUI [1,3])
C0280803 (UMLS CUI [2])
C0220654 (UMLS CUI [3])
Hepatitis B | Markers Quantity | Hepatitis B Surface Antigens | Hepatitis B e Antigens | Anti-HBc antibody | Hepatitis B virus DNA
Item
5. past or active hepatitis b (at least one of the following markers hbsag, hbe ag, anti-hbc, hbv dna).
boolean
C0019163 (UMLS CUI [1])
C0005516 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0019168 (UMLS CUI [3])
C0019167 (UMLS CUI [4])
C0948759 (UMLS CUI [5])
C0369332 (UMLS CUI [6])
Hepatitis C | HIV Infection | Immunosuppression Severe
Item
6. hcv infection. hiv infection or other conditions of severe immunosuppression.
boolean
C0019196 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C4048329 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
Malignant Neoplasms Previous | Exception Skin carcinoma | Exception Cervix carcinoma | Exception Malignant Neoplasm Treated
Item
7. previous neoplasms except non-melanoma skin cancer of the cervix or adequately treated.
boolean
C0006826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0302592 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0006826 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
Congestive heart failure New York Heart Association Classification
Item
8. congestive heart failure> nyha grade 1.
boolean
C0018802 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Renal Insufficiency | Creatinine increased | Creatinine clearance measurement | Relationship Absent Lymphoma
Item
9. impaired renal function (creatinine> 1.5 x upper limit of normal, uln) or creatinine clearance <50 ml / h, not related to lymphoma.
boolean
C1565489 (UMLS CUI [1])
C0151578 (UMLS CUI [2])
C0373595 (UMLS CUI [3])
C0439849 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0024299 (UMLS CUI [4,3])
Liver Dysfunction | Elevated total bilirubin | Aspartate aminotransferase increased | Alanine aminotransferase increased | Gamma-glutamyl transferase raised | Relationship Absent Lymphoma
Item
10. impaired liver function (bilirubin, ast / alt or ggt> 2 x uln) were not related to lymphoma.
boolean
C0086565 (UMLS CUI [1])
C0741494 (UMLS CUI [2])
C0151904 (UMLS CUI [3])
C0151905 (UMLS CUI [4])
C0151662 (UMLS CUI [5])
C0439849 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0024299 (UMLS CUI [6,3])
Breast Feeding | Pregnancy
Item
11. women who are nursing or pregnant.
boolean
C0006147 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
Heart Disease | Lung disease | Nervous system disorder | Mental disorders | Metabolic Disease Severe | Independent of Lymphoma
Item
12. patients with heart disease, pulmonary, neurological, psychiatric or severe metabolic and not secondary to lymphoma.
boolean
C0018799 (UMLS CUI [1])
C0024115 (UMLS CUI [2])
C0027765 (UMLS CUI [3])
C0004936 (UMLS CUI [4])
C0025517 (UMLS CUI [5,1])
C0205082 (UMLS CUI [5,2])
C0332291 (UMLS CUI [6,1])
C0024299 (UMLS CUI [6,2])
Communicable Disease Severe | Chronic infectious disease
Item
13. severe acute or chronic infection in activity.
boolean
C0009450 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0151317 (UMLS CUI [2])
Comorbidity Interferes with Study Subject Participation Status
Item
14. any other concurrent medical or psychological comorbidity that might interfere with participation in this study.
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])