Age
Item
1. age 18 years and older
boolean
C0001779 (UMLS CUI [1])
Recurrent Indolent Adult Non-Hodgkin Lymphoma Untreated WHO classification | Follicular Lymphoma low grade | Marginal Zone B-Cell Lymphoma | Lymphoplasmacytic lymphoma | Small Lymphocytic Lymphoma
Item
2. histologically confirmed (by who classification) untreated and relapsed indolent non-hodgkin's b-cell lymphoma of low-grade follicular, marginal zone, lymphoplasmocytic or small lymphocytic subtypes.
boolean
C0677723 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C4267671 (UMLS CUI [1,3])
C0024301 (UMLS CUI [2,1])
C1282907 (UMLS CUI [2,2])
C1367654 (UMLS CUI [3])
C0024419 (UMLS CUI [4])
C0855095 (UMLS CUI [5])
Ann Arbor lymphoma staging system
Item
3. stage iii/iv
boolean
C0432516 (UMLS CUI [1])
Bone Marrow function | White Blood Cell Count procedure | Neutrophil count | Platelet Count measurement
Item
4. adequate bone marrow function (leukocyte count>2,0, neutrophil count>1.0, platelets>50)
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0023508 (UMLS CUI [2])
C0200633 (UMLS CUI [3])
C0032181 (UMLS CUI [4])
Lymph nodes Quantity Biopsy | Lymph nodes Quantity Therapeutic procedure | Size of lymph node
Item
5. two or more separate lymph nodes > 1,5 cm available for biopsy or treatment.
boolean
C0024204 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0005558 (UMLS CUI [1,3])
C0024204 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C1285847 (UMLS CUI [3])
Measurable Disease | Exception Biopsy Site | Exception Injection Site
Item
6. measurable disease present other than biopsy site and injection site(s).
boolean
C1513041 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0005558 (UMLS CUI [2,2])
C1515974 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C1533685 (UMLS CUI [3,2])
C1515974 (UMLS CUI [3,3])
Washout Period Required | Status post Prior Therapy | Chemotherapy | Therapeutic radiology procedure | rituximab
Item
7. required wash-out period after previous treatment: chemotherapy - 8 weeks, radiotherapy - 4 weeks, rituximab - 12 weeks
boolean
C1710661 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0231290 (UMLS CUI [2,1])
C1514463 (UMLS CUI [2,2])
C0392920 (UMLS CUI [3])
C1522449 (UMLS CUI [4])
C0393022 (UMLS CUI [5])
WHO performance status scale
Item
8. who status 0-1
boolean
C1298650 (UMLS CUI [1])
Life Expectancy
Item
9. life expectancy of more than 6 months
boolean
C0023671 (UMLS CUI [1])
Informed Consent
Item
10. written informed consent
boolean
C0021430 (UMLS CUI [1])
Treatment Compliance
Item
11. able to comply with the treatment protocol -
boolean
C4319828 (UMLS CUI [1])
Lymphoma Progressive | Patient need for Systemic therapy | Patient need for Irradiation Standard Dose
Item
1. patients with progressive lymphoma in need of systemic therapy or standard dose irradiation.
boolean
C0024299 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C0686904 (UMLS CUI [2,1])
C1515119 (UMLS CUI [2,2])
C0686904 (UMLS CUI [3,1])
C1522449 (UMLS CUI [3,2])
C1442989 (UMLS CUI [3,3])
C0178602 (UMLS CUI [3,4])
Bacterial Infection chronic | Virus Disease chronic | Mycoses chronic
Item
2. chronic bacterial, viral or fungal infection
boolean
C0004623 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0042769 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
C0026946 (UMLS CUI [3,1])
C0205191 (UMLS CUI [3,2])
Autoimmune Disease Pre-existing | Disease Due to Antibodies | Lupus Erythematosus, Systemic | Rheumatoid Arthritis | Multiple Sclerosis | Sjogren's Syndrome | Autoimmune thrombocytopenia | Exception Thyroid Disease Controlled | Exception Autoantibodies Without Autoimmune Diseases
Item
3. pre-existing autoimmune or antibody mediated disease including: systemic lupus, erythematosus, rheumatoid arthritis, multiple sclerosis, sjogren's syndrome, autoimmune thrombocytopenia, but excluding controlled thyroid disease, or the presence of autoantibodies without clinical autoimmune disease.
boolean
C0004364 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0003241 (UMLS CUI [2,3])
C0024141 (UMLS CUI [3])
C0003873 (UMLS CUI [4])
C0026769 (UMLS CUI [5])
C1527336 (UMLS CUI [6])
C0242584 (UMLS CUI [7])
C1705847 (UMLS CUI [8,1])
C0040128 (UMLS CUI [8,2])
C2911690 (UMLS CUI [8,3])
C1705847 (UMLS CUI [9,1])
C0004358 (UMLS CUI [9,2])
C0332288 (UMLS CUI [9,3])
C0004364 (UMLS CUI [9,4])
HIV Infection
Item
4. known history of hiv
boolean
C0019693 (UMLS CUI [1])
Central Nervous System Involvement Lymphoma
Item
5. central nervous system involvement of lymphoma
boolean
C4050309 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
Anticoagulant therapy Discontinuation Unsuccessful | Aspirin U/day allowed
Item
6. current anticoagulant therapy which can not safely be paused during treatment injections (asa < 325 mg/day allowed)
boolean
C0150457 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C1272705 (UMLS CUI [1,3])
C0004057 (UMLS CUI [2,1])
C0456683 (UMLS CUI [2,2])
C0683607 (UMLS CUI [2,3])
Pregnancy
Item
7. pregnancy -
boolean
C0032961 (UMLS CUI [1])