Lymphoma, Follicular
Item
confirmed diagnosis of follicular lymphoma, according to the revised european american lymphoma/world health organization [real/who] classification
boolean
C0024301 (UMLS CUI [1])
Follicular Lymphoma CD40 Positive
Item
documented cd40+ follicular lymphoma
boolean
C0024301 (UMLS CUI [1,1])
C0054959 (UMLS CUI [1,2])
C1514241 (UMLS CUI [1,3])
Measurable Disease
Item
measurable lesion
boolean
C1513041 (UMLS CUI [1])
Unresponsive to Rituximab
Item
refractory to rituximab
boolean
C0205269 (UMLS CUI [1,1])
C0393022 (UMLS CUI [1,2])
Chemotherapy Regimen Quantity Previous
Item
prior treatment with at least 1 chemotherapeutic regimen
boolean
C0392920 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,3])
Age
Item
18 years or older
boolean
C0001779 (UMLS CUI [1])
WHO performance status scale
Item
who performance status grade 0, 1, or 2
boolean
C1298650 (UMLS CUI [1])
Life Expectancy
Item
life expectancy > 3 months
boolean
C0023671 (UMLS CUI [1])
Informed Consent
Item
obtained written informed consent
boolean
C0021430 (UMLS CUI [1])
Follicular Lymphoma Ann Arbor lymphoma staging system | Transformation Aggressive Lymphoma | Transformation Diffuse Large B-Cell Lymphoma
Item
grade 3b follicular lymphoma or evidence that the indolent lymphoma has transformed to aggressive lymphoma (i.e. dlbcl)
boolean
C0024301 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
C3714584 (UMLS CUI [2,1])
C1332225 (UMLS CUI [2,2])
C3714584 (UMLS CUI [3,1])
C0079744 (UMLS CUI [3,2])
Cancer Other Clinical Significance | Cancer Other Requirement Intervention
Item
history of another primary malignancy that is currently clinically significant or currently requires active intervention
boolean
C1707251 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C1707251 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0184661 (UMLS CUI [2,3])
Allogeneic Stem Cell Transplantation Previous
Item
prior allogeneic stem cell transplantation
boolean
C2242529 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Infusion related reaction Anaphylaxis | Infusion related reaction Severe | Intolerance Administration Immune Globulin (Human) | Intolerance Administration Monoclonal Antibodies
Item
prior anaphylactic or other severe infusion reaction such that the patient is unable to tolerate human immunoglobulin or monoclonal antibody administration
boolean
C0948715 (UMLS CUI [1,1])
C0002792 (UMLS CUI [1,2])
C0948715 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0231199 (UMLS CUI [3,1])
C1533734 (UMLS CUI [3,2])
C0358321 (UMLS CUI [3,3])
C0231199 (UMLS CUI [4,1])
C1533734 (UMLS CUI [4,2])
C0003250 (UMLS CUI [4,3])
Decreased cardiac function | Heart Disease Clinical Significance
Item
impaired cardiac function or clinically significant cardiac disease
boolean
C0232166 (UMLS CUI [1])
C0018799 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
Pancreatitis | Pancreatitis, Chronic | Operation on pancreas | Risk factors Pancreatitis
Item
history of acute or chronic pancreatitis, surgery of the pancreas, or any risk factors that may increase the risk of pancreatitis
boolean
C0030305 (UMLS CUI [1])
C0149521 (UMLS CUI [2])
C0193594 (UMLS CUI [3])
C0035648 (UMLS CUI [4,1])
C0030305 (UMLS CUI [4,2])
Communicable Disease Requirement Systemic therapy | Virus Diseases | Bacterial Infections | Mycoses
Item
history of an active infection (viral, bacterial, or fungal) requiring systemic therapy within 28 days before study treatment.
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1515119 (UMLS CUI [1,3])
C0042769 (UMLS CUI [2])
C0004623 (UMLS CUI [3])
C0026946 (UMLS CUI [4])
HIV Infection
Item
known diagnosis of human immunodeficiency virus (hiv) infection
boolean
C0019693 (UMLS CUI [1])
Viral hepatitis Previous | Hepatitis B | Hepatitis C
Item
evidence of previous hepatitis viral infection such as hepatitis b or hepatitis c
boolean
C0042721 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Adrenal Cortex Hormones | Prednisone U/day | Equivalent
Item
ongoing corticosteroid use (>10 mg/day prednisone or equivalent)
boolean
C0001617 (UMLS CUI [1])
C0032952 (UMLS CUI [2,1])
C0456683 (UMLS CUI [2,2])
C0205163 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
pregnant or nursing (lactating) women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Eligibility Criteria Study Protocol
Item
other protocol-defined inclusion/exclusion criteria may apply
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])