Population All
Item
all population:
boolean
C1257890 (UMLS CUI [1,1])
C0444868 (UMLS CUI [1,2])
Chinese People
Item
chinese population
boolean
C0152035 (UMLS CUI [1])
Hematologic function | Platelet Count measurement | Hemoglobin measurement | Gender | White Blood Cell Count
Item
adequate hematological function: platelet count greater than or equal to (>=) 100*10^9 per liter (/l), hemoglobin (hb) >= 12 grams/deciliter (g/dl) (male) or >= 11 g/dl (female), white blood cell (wbc) count >= 4*10^9/l and <= 11*10^9/l
boolean
C0221130 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
C0079399 (UMLS CUI [4])
C0023508 (UMLS CUI [5])
Healthy Volunteers
Item
healthy volunteers:
boolean
C1708335 (UMLS CUI [1])
Disease Absent | Chronic disease Absent
Item
absence of evidence of any active or chronic disease
boolean
C0012634 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0008679 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Hepatitis B DNA Negative | Hepatitis B surface antigen negative | Hepatitis B surface antibody negative | Hepatitis B e Antigens Negative | Hepatitis Be antibody Negative | Hepatitis B core antibody (HBcAb) Negative
Item
negative hepatitis b virus deoxyribonucleic acid (hbv dna), hepatitis b surface antigen (hbsag), hepatitis b surface antibody (hbsab), hepatitis b envelope antigen (hbeag), hepatitis b envelope antiody (hbeab) and hepatitis b core antibody (hbcab)
boolean
C3641250 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
C0919711 (UMLS CUI [2])
C0744842 (UMLS CUI [3])
C0019167 (UMLS CUI [4,1])
C1513916 (UMLS CUI [4,2])
C0201484 (UMLS CUI [5,1])
C1513916 (UMLS CUI [5,2])
C3702086 (UMLS CUI [6,1])
C1513916 (UMLS CUI [6,2])
Liver function | Alanine aminotransferase measurement
Item
adequate liver function: transaminases alanine aminotransferase (alt) <= 1.0 times the upper limit of normal (uln)
boolean
C0232741 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Therapy naive | Chronic Hepatitis B
Item
treatment naïve chb patients:
boolean
C0919936 (UMLS CUI [1])
C0524909 (UMLS CUI [2])
Hepatitis B surface antigen positive | Liver function Compensated | Non-cirrhotic
Item
hbsag-positive (>=250 international unit/milliliter [iu/ml]), compensated liver function, non-cirrhotic
boolean
C0149709 (UMLS CUI [1])
C0232741 (UMLS CUI [2,1])
C0205432 (UMLS CUI [2,2])
C0439687 (UMLS CUI [3])
Hepatitis B e antigen positive | Hepatitis B DNA Measurement | Alanine aminotransferase increased
Item
hbeag-positive, hbv dna >= 200,000 iu/ml or equivalent copies/ml, alt >1.5 times the uln and alt <8 times the uln
boolean
C0392390 (UMLS CUI [1])
C3641250 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
Hepatitis B e Antigens Negative | Nucleoside Analogs | Nucleotide analog | Chronic Hepatitis B
Item
hbeag-negative nucleoside/nucleotide analogue-treated chb patients:
boolean
C0019167 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
C1579410 (UMLS CUI [2])
C0597107 (UMLS CUI [3])
C0524909 (UMLS CUI [4])
Hepatitis B e Antigens Seroconversion | Nucleoside Analogs | Nucleotide analog | Hepatitis B DNA Measurement | Hepatitis B DNA Undetectable | Hepatitis B e Antigens Negative | Hepatitis B e antibody positive
Item
subjects who hbeag-seroconverted on nucleoside/nucleotide analogue therapy (treatment for 1 to 3 years prior to enrollment) with hbv dna <90 iu/ml or below a detection level acceptable by both the sponsor and investigator for at least the preceding 6 months; hbeag negative and hbeab positive
boolean
C0019167 (UMLS CUI [1,1])
C4042908 (UMLS CUI [1,2])
C1579410 (UMLS CUI [2])
C0597107 (UMLS CUI [3])
C3641250 (UMLS CUI [4])
C3641250 (UMLS CUI [5,1])
C3827727 (UMLS CUI [5,2])
C0019167 (UMLS CUI [6,1])
C1513916 (UMLS CUI [6,2])
C3203521 (UMLS CUI [7])
Hepatitis B surface antigen positive | Liver function Compensated | Non-cirrhotic | Alanine aminotransferase measurement
Item
hbsag-positive (>=250 iu/ml), compensated liver function, non-cirrhotic -alt <= 1*uln
boolean
C0149709 (UMLS CUI [1])
C0232741 (UMLS CUI [2,1])
C0205432 (UMLS CUI [2,2])
C0439687 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
Steroid use Impact White blood cell number | Immunosuppressive Agents Impact White blood cell number | Steroid use Impact Leukocyte function | Immunosuppressive Agents Impact Leukocyte function
Item
use of steroids or other immune suppressive agents within the last 4 weeks that would impact the number/functions of white blood cells (wbc)
boolean
C0281991 (UMLS CUI [1,1])
C4049986 (UMLS CUI [1,2])
C0427512 (UMLS CUI [1,3])
C0021081 (UMLS CUI [2,1])
C4049986 (UMLS CUI [2,2])
C0427512 (UMLS CUI [2,3])
C0281991 (UMLS CUI [3,1])
C4049986 (UMLS CUI [3,2])
C0023516 (UMLS CUI [3,3])
C0031843 (UMLS CUI [3,4])
C0021081 (UMLS CUI [4,1])
C4049986 (UMLS CUI [4,2])
C0023516 (UMLS CUI [4,3])
C0031843 (UMLS CUI [4,4])
Comorbidity | Laboratory test finding | Disease Interferes with Research results | Condition Interferes with Research results | Malignant Neoplasms | Lupus Erythematosus | Rheumatoid Arthritis | Autoimmune Disease
Item
any other diseases or clinical laboratory finding giving reasonable suspicion of a disease or condition (including, but not limited to, cancer, lupus erythematosus, rheumatoid arthritis, or other autoimmune disease) that could confound the result of the study
boolean
C0009488 (UMLS CUI [1])
C0587081 (UMLS CUI [2])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0683954 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0683954 (UMLS CUI [4,3])
C0006826 (UMLS CUI [5])
C0409974 (UMLS CUI [6])
C0003873 (UMLS CUI [7])
C0004364 (UMLS CUI [8])
Hepatitis A virus IgM antibody positive | Hepatitis C antibody positive | HIV Seropositivity
Item
positive hepatitis a immunoglobulin m (igm) antibody, hepatitis c antibody (hcv ab) or human immunodeficiency virus (hiv) at screening
boolean
C1096503 (UMLS CUI [1])
C0281863 (UMLS CUI [2])
C0019699 (UMLS CUI [3])
Communicable Disease | Influenza | Gastrointestinal symptom | Illness Clinical Significance
Item
significant acute infection, example; influenza, acute gastrointestinal symptoms or any other clinically significant illness within 2 weeks
boolean
C0009450 (UMLS CUI [1])
C0021400 (UMLS CUI [2])
C0426576 (UMLS CUI [3])
C0221423 (UMLS CUI [4,1])
C2826293 (UMLS CUI [4,2])
Interferon therapy Chronic Hepatitis B
Item
previous/concurrent treatment with interferon-based therapy for chb
boolean
C0279030 (UMLS CUI [1,1])
C0524909 (UMLS CUI [1,2])