Eligibility Criteria General
Item
general inclusion/exclusion criteria:
boolean
C1516637 (UMLS CUI [1,1])
C0205246 (UMLS CUI [1,2])
Cardiomyopathy Stable Duration | Ischemic cardiomyopathy | Non-ischemic cardiomyopathy | Age | Therapy Optimal
Item
the study group will include subjects with a history of stable cardiomyopathy (ischemic and non-ischemic, >3 months duration, ages 45-75 yrs) despite a minimum of 6 weeks of optimal treatment.
boolean
C0878544 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
C0349782 (UMLS CUI [2])
C0877438 (UMLS CUI [3])
C0001779 (UMLS CUI [4])
C0087111 (UMLS CUI [5,1])
C2698651 (UMLS CUI [5,2])
Therapy Optimal | Angiotensin-Converting Enzyme Inhibitors
Item
optimal therapy will be according to aha/acc and hfsa hf guidelines, including treatment with ace and -blocker therapy (for at least 6 weeks), or have documented reason for variation, including medication intolerance, contraindication, patient preference, or personal physician's judgment.
boolean
C0087111 (UMLS CUI [1,1])
C2698651 (UMLS CUI [1,2])
C0003015 (UMLS CUI [2])
Symptoms New York Heart Association Classification | Left ventricular ejection fraction | Tobacco use Absent | Tobacco use Minimal | Smoking cigarettes: ____ pack-years history | Artificial cardiac pacemaker Absent
Item
patient enrollment will be limited to those individuals with nyha class ii and iii symptoms, lvef<35%, with no or minimal smoking history (<15 pk yrs), and without pacemakers.
boolean
C1457887 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
C0428772 (UMLS CUI [2])
C0543414 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0543414 (UMLS CUI [4,1])
C0547040 (UMLS CUI [4,2])
C2230126 (UMLS CUI [5])
C0030163 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
Atrial Fibrillation | Heart failure Secondary to Atrial Fibrillation
Item
patients with atrial fibrillation or hf believed to be secondary to atrial fibrillation will be excluded.
boolean
C0004238 (UMLS CUI [1])
C0018801 (UMLS CUI [2,1])
C0175668 (UMLS CUI [2,2])
C0004238 (UMLS CUI [2,3])
Heart failure Secondary to Valvular disease | Exception Mitral Valve Insufficiency Secondary to Left Ventricular Dysfunction
Item
patients with hf secondary to significant uncorrected primary valvular disease (except mitral regurgitation secondary to left ventricular dysfunction) will also be excluded.
boolean
C0018801 (UMLS CUI [1,1])
C0175668 (UMLS CUI [1,2])
C3258293 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0026266 (UMLS CUI [2,2])
C0175668 (UMLS CUI [2,3])
C0242698 (UMLS CUI [2,4])
Sedentary | Absence Physical activity Regular | Activity level Physical activity questionnaire
Item
patients will be sedentary, defined here as no regular physical activity for at least the prior 6 months and current activity level will be documented by an activity questionnaire.
boolean
C1532253 (UMLS CUI [1])
C0332197 (UMLS CUI [2,1])
C0026606 (UMLS CUI [2,2])
C0205272 (UMLS CUI [2,3])
C0683317 (UMLS CUI [3,1])
C4264334 (UMLS CUI [3,2])
Orthopedic problem Preventing Knee Extensor Exercise
Item
patients must have no orthopedic limitations that would prohibit them from performing knee-extensor exercise.
boolean
C0029354 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0581537 (UMLS CUI [1,3])
C0015259 (UMLS CUI [1,4])
Postmenopausal state | Female Sterilization | Amenorrhea Duration | Gender Uterus Absent | Follicle stimulating hormone measurement
Item
due to the typical age of patients with hf, all women will be postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years, and in women without a uterus, follicle stimulating hormone (fsh) >40 iu/l.
boolean
C0232970 (UMLS CUI [1])
C0015787 (UMLS CUI [2])
C0002453 (UMLS CUI [3,1])
C0449238 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4,1])
C0042149 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C0202022 (UMLS CUI [5])
Gender Hormone replacement therapy
Item
women currently taking hormone replacement therapy (hrt) will be excluded from the proposed studies due to the direct vascular effects of hrt comorbidity exclusion criteria: patients with significant non-cardiac comorbidities, which if present could alter the study results, will be excluded.
boolean
C0079399 (UMLS CUI [1,1])
C0282402 (UMLS CUI [1,2])
Dementia
Item
these include a diagnosis of dementia
boolean
C0497327 (UMLS CUI [1])
Severe chronic obstructive pulmonary disease
Item
severe copd
boolean
C0730607 (UMLS CUI [1])
Peripheral Vascular Disease
Item
peripheral vascular disease
boolean
C0085096 (UMLS CUI [1])
Anemia
Item
anemia
boolean
C0002871 (UMLS CUI [1])
Abnormal breathing Sleep Related
Item
sleep-related breathing disorder
boolean
C1260922 (UMLS CUI [1,1])
C0037313 (UMLS CUI [1,2])
C0439849 (UMLS CUI [1,3])
Heart valve disease Severe
Item
severe valvular heart disease
boolean
C0018824 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Diabetes Mellitus | Insulin regime
Item
diabetes (if on insulin therapy)
boolean
C0011849 (UMLS CUI [1])
C0557978 (UMLS CUI [2])
End stage cancer
Item
or end-stage malignancy
boolean
C0741884 (UMLS CUI [1])
Obesity, Morbid | Body mass index | Uncontrolled hypertension | Anemia | Hemoglobin measurement | Renal Insufficiency Severe | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
we will also exclude morbidly obese patients (bmi >35), patients with uncontrolled hypertension (>160/100), anemia (hgb<9) and severe renal insufficiency (individuals with creatinine clearance <30 by the cockcroft-gault formula).
boolean
C0028756 (UMLS CUI [1])
C1305855 (UMLS CUI [2])
C1868885 (UMLS CUI [3])
C0002871 (UMLS CUI [4])
C0518015 (UMLS CUI [5])
C1565489 (UMLS CUI [6,1])
C0205082 (UMLS CUI [6,2])
C2711451 (UMLS CUI [7])