Age | Informed Consent
Item
older than 18 years and able to give informed consent
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Decompensated cardiac failure Recent
Item
clinical diagnosis of acute decompensated heart failure within the previous 8 h
boolean
C0581377 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Sign or Symptom Quantity Congestion | Edema Chest X-ray | Ascites Chest X-ray | Jugular venous engorgement Chest X-ray | Pulmonary congestion Vascular Chest X-ray
Item
at least two clinical signs of congestion (edema, ascites, jugular venous distension, or pulmonary vascular congestion on chest radiography)
boolean
C3540840 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0700148 (UMLS CUI [1,3])
C0013604 (UMLS CUI [2,1])
C0039985 (UMLS CUI [2,2])
C0003962 (UMLS CUI [3,1])
C0039985 (UMLS CUI [3,2])
C0425687 (UMLS CUI [4,1])
C0039985 (UMLS CUI [4,2])
C0242073 (UMLS CUI [5,1])
C1801960 (UMLS CUI [5,2])
C0039985 (UMLS CUI [5,3])
Maintenance therapy | Loop Diuretics Oral | Bumetanide Dose | Equivalent Furosemide Dose | Equivalent Torsemide Dose
Item
maintenance therapy with oral loop diuretics at a dose of at least 1 mg bumetanide (1 mg bumetanide = 40 mg furosemide = 20 mg torsemide) for at least 1 month before hospital admission
boolean
C0677908 (UMLS CUI [1])
C0354100 (UMLS CUI [2,1])
C1527415 (UMLS CUI [2,2])
C0006376 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0205163 (UMLS CUI [4,1])
C0016860 (UMLS CUI [4,2])
C0178602 (UMLS CUI [4,3])
C0205163 (UMLS CUI [5,1])
C0076840 (UMLS CUI [5,2])
C0178602 (UMLS CUI [5,3])
N-Terminal ProB-type Natriuretic Peptide Measurement
Item
nt-probnp >1000 ng/l
boolean
C3272900 (UMLS CUI [1])
Left ventricular ejection fraction
Item
left ventricular ejection fraction <50%
boolean
C0428772 (UMLS CUI [1])
Criteria Quantity
Item
at least one out of three of the following criteria:
boolean
C0243161 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Serum sodium measurement
Item
serum sodium <136 mmol/l
boolean
C0523891 (UMLS CUI [1])
Urea to Creatinine Ratio Measurement | Comparison BUN/Creatinine ratio
Item
serum urea/creatinine ratio >50 (comparable to a bun/creatinine ratio >25)
boolean
C3272926 (UMLS CUI [1])
C1707455 (UMLS CUI [2,1])
C0201922 (UMLS CUI [2,2])
Serum creatinine raised
Item
admission serum creatinine increased with >0.3 mg/dl compared to previous value within 3 months before admission
boolean
C0700225 (UMLS CUI [1])
Heart Transplantation | Artificial Ventricle
Item
history of cardiac transplantation and/or ventricular assist device
boolean
C0018823 (UMLS CUI [1])
C0085842 (UMLS CUI [2])
Acute Coronary Syndrome | Chest Pain Typical | Electrocardiographic changes In addition to Troponin increased
Item
concurrent diagnosis of an acute coronary syndrome defined as typical chest pain and/or electrocardiographic changes in addition to a troponin rise >99th percentile
boolean
C0948089 (UMLS CUI [1])
C0008031 (UMLS CUI [2,1])
C3538928 (UMLS CUI [2,2])
C0855329 (UMLS CUI [3,1])
C0332287 (UMLS CUI [3,2])
C1141948 (UMLS CUI [3,3])
Mean blood pressure | Systolic Pressure
Item
mean arterial blood pressure <65 mmhg, or systolic blood pressure <90 mmhg at the moment of admission
boolean
C0428886 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
Inotropic agent Intravenous | Vasoconstrictor Agents | Nitroprusside
Item
use of intravenous inotropes, vasopressors or nitroprusside at any time point during the study
boolean
C0304509 (UMLS CUI [1,1])
C1522726 (UMLS CUI [1,2])
C0042397 (UMLS CUI [2])
C0028193 (UMLS CUI [3])
Estimated Glomerular Filtration Rate CKD-EPI
Item
a baseline estimated glomerular filtration rate <15 ml/min/1.73m² according to the chronic kidney disease epidemiology collaboration (ckd-epi) formula at the moment of inclusion
boolean
C3811844 (UMLS CUI [1,1])
C2964649 (UMLS CUI [1,2])
Renal Replacement Therapy | Ultrafiltration
Item
use of renal replacement therapy or ultrafiltration before study inclusion
boolean
C0206074 (UMLS CUI [1])
C0041612 (UMLS CUI [2])
Acetazolamide
Item
treatment with acetazolamide within the previous month
boolean
C0000981 (UMLS CUI [1])
Bumetanide Dose | Equivalent Dose
Item
treatment with ≥2 mg bumetanide or an equivalent dose during the index hospitalization before randomization
boolean
C0006376 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205163 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
Diuretics | Vasopressin Antagonist | Mineralocorticoid Receptor Antagonists
Item
use of diuretics, vasopressin antagonists or mineralocorticoid receptor antagonist not specified by the protocol
boolean
C0012798 (UMLS CUI [1])
C3537128 (UMLS CUI [2])
C1579268 (UMLS CUI [3])
Exposure to Agent Nephrotoxic | Exposure to Contrast dye
Item
exposure to nephrotoxic agents (i.e. contrast dye) anticipated within 3 days
boolean
C0332157 (UMLS CUI [1,1])
C1254351 (UMLS CUI [1,2])
C1514118 (UMLS CUI [1,3])
C0332157 (UMLS CUI [2,1])
C0742795 (UMLS CUI [2,2])