Age
Item
age 18 years or older
boolean
C0001779 (UMLS CUI [1])
Left ventricular ejection fraction
Item
most recent lvef to be ≤ 40% by any method within 12 months of randomization.
boolean
C0428772 (UMLS CUI [1])
High risk of Heart failure
Item
high risk heart failure as defined by the following criteria:
boolean
C0332167 (UMLS CUI [1,1])
C0018801 (UMLS CUI [1,2])
Heart failure Event
Item
a heart failure event in the prior 12 months, defined as any one of the following:
boolean
C0018801 (UMLS CUI [1,1])
C0441471 (UMLS CUI [1,2])
Hospitalization Due to Heart Failure
Item
hf hospitalization
boolean
C3898876 (UMLS CUI [1])
Emergency department Therapy Heart failure
Item
treatment in the emergency department (or equivalent) for heart failure
boolean
C0562508 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0018801 (UMLS CUI [1,3])
Outpatient treatment Heart failure | Diuretics Intravenous
Item
outpatient treatment for heart failure with intravenous diuretics
boolean
C0002423 (UMLS CUI [1,1])
C0018801 (UMLS CUI [1,2])
C0012798 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
N-Terminal ProB-type Natriuretic Peptide Measurement | Brain natriuretic peptide measurement
Item
nt-probnp greater than 2000 pg/ml or bnp greater than 400 pg/ml at any time during the 30 days prior to randomization
boolean
C3272900 (UMLS CUI [1])
C1095989 (UMLS CUI [2])
Informed Consent
Item
willing to provide informed consent
boolean
C0021430 (UMLS CUI [1])
Acute Coronary Syndrome | Myocardial Revascularization
Item
acute coronary syndrome (clinical diagnosis) or cardiac revascularization procedure within 30 days
boolean
C0948089 (UMLS CUI [1])
C0027056 (UMLS CUI [2])
Cardiac Resynchronization Therapy | Implantation of CRT-D Planned
Item
cardiac resynchronization therapy (crt) within prior 3 months or current plan to implant crt device
boolean
C1167956 (UMLS CUI [1])
C1135480 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
Myocarditis | Hypertrophic Cardiomyopathy | Pericarditis | Restrictive cardiomyopathy
Item
active myocarditis, hypertrophic obstructive cardiomyopathy, pericarditis, or restrictive cardiomyopathy
boolean
C0027059 (UMLS CUI [1])
C0007194 (UMLS CUI [2])
C0031046 (UMLS CUI [3])
C0007196 (UMLS CUI [4])
Valvular stenosis Severe
Item
severe stenotic valvular disease
boolean
C1883524 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Heart Transplantation Anticipated | Artificial Ventricle Anticipated
Item
anticipated heart transplantation or ventricular assist device within 12 months
boolean
C0018823 (UMLS CUI [1,1])
C3840775 (UMLS CUI [1,2])
C0085842 (UMLS CUI [2,1])
C3840775 (UMLS CUI [2,2])
Inotropic agent chronic
Item
chronic inotropic therapy
boolean
C0304509 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
Complex congenital heart disease
Item
complex congenital heart disease
boolean
C0744669 (UMLS CUI [1])
Kidney Failure, Chronic | Renal Replacement Therapy
Item
end stage renal disease with renal replacement therapy
boolean
C0022661 (UMLS CUI [1])
C0206074 (UMLS CUI [2])
Terminal illness | Exception Heart Disease | Life Expectancy
Item
non cardiac terminal illness with expected survival less than 12 months
boolean
C0679247 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0018799 (UMLS CUI [2,2])
C0023671 (UMLS CUI [3])
Pregnancy | Pregnancy, Planned
Item
women who are pregnant or planning to become pregnant
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
Protocol Compliance Unable
Item
inability to comply with planned study procedures
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Study Subject Participation Status | Clinical Trial
Item
enrollment or planned enrollment in another clinical trial
boolean
C2348568 (UMLS CUI [1])
C0008976 (UMLS CUI [2])