Triple-Negative Breast Cancer | Cisplatin
Item
patients will have metastatic triple negative breast cancer (tnbc) and are about to receive treatment with single agent cisplatin
boolean
C2348819 (UMLS CUI [1])
C0008838 (UMLS CUI [2])
Measurable Disease | Bone Disease | Physical Examination | Imaging
Item
measurable disease including bone disease as determined by physical exam or imaging
boolean
C1513041 (UMLS CUI [1])
C0005940 (UMLS CUI [2])
C0031809 (UMLS CUI [3])
C0011923 (UMLS CUI [4])
Neoplasm suitable Biopsy | Patients Fit | Tissue biopsy Tumor tissue sample | Operative Surgical Procedures Tumor tissue sample
Item
patients must have tumor suitable for biopsy (as assessed by trained specialists in radiology); patients must be medically fit and willing to undergo repeated tissue biopsies or surgical procedures to get tumor tissue
boolean
C0027651 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0005558 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C0424576 (UMLS CUI [2,2])
C3864006 (UMLS CUI [3,1])
C0475358 (UMLS CUI [3,2])
C0543467 (UMLS CUI [4,1])
C0475358 (UMLS CUI [4,2])
Informed Consent | Protocol Compliance
Item
written informed consent obtained from subject and ability for subject to comply with the requirements of the study
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
Informed Consent Procedure Specific
Item
procedure-specific signed informed consent prior to initiation of any study-related procedures
boolean
C0021430 (UMLS CUI [1,1])
C0184661 (UMLS CUI [1,2])
C0205369 (UMLS CUI [1,3])
ECOG performance status | Karnofsky Performance Status
Item
eastern cooperative oncology group (ecog) performance status of 0-1 (or a karnofsky performance status of >= 50%)
boolean
C1520224 (UMLS CUI [1])
C0206065 (UMLS CUI [2])
Clinical Data Release Databases
Item
agree to allow their de-identified clinical and laboratory data to be posted to publicly available databases such as database of genotypes and phenotypes (dbgap)
boolean
C1516606 (UMLS CUI [1,1])
C1283071 (UMLS CUI [1,2])
C0242356 (UMLS CUI [1,3])
Minorities
Item
minorities are included in this protocol
boolean
C0026192 (UMLS CUI [1])
History of cancer
Item
patients with a prior history of malignancy remain eligible
boolean
C0455471 (UMLS CUI [1])
Neoplastic Syndromes, Hereditary | Medical History Suggestive of Hereditary Neoplastic Syndrome
Item
patients with an inherited cancer syndrome or a medical history suggestive of an inherited cancer syndrome remain eligible
boolean
C0027672 (UMLS CUI [1])
C0262926 (UMLS CUI [2,1])
C0332299 (UMLS CUI [2,2])
C0027672 (UMLS CUI [2,3])
Patient Medically unfit Tissue biopsy | Condition compromises Patient safety | Abnormality compromises Patient safety | Condition compromises Data Quality | Abnormality compromises Data Quality
Item
it is at the enrolling study oncologist's discretion to decide if a patient is not fit enough to undergo tissue biopsy; presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data
boolean
C0030705 (UMLS CUI [1,1])
C3841806 (UMLS CUI [1,2])
C3864006 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C2945640 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
C1704258 (UMLS CUI [3,1])
C2945640 (UMLS CUI [3,2])
C1113679 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C2945640 (UMLS CUI [4,2])
C0242483 (UMLS CUI [4,3])
C1704258 (UMLS CUI [5,1])
C2945640 (UMLS CUI [5,2])
C0242483 (UMLS CUI [5,3])
Blood Coagulation Disorder
Item
significant bleeding disorder
boolean
C0005779 (UMLS CUI [1])
Pregnancy | Breast Feeding | Contraceptive methods Unwilling
Item
pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C0558080 (UMLS CUI [3,2])
Prisoners
Item
prisoners
boolean
C0033167 (UMLS CUI [1])
Informed Consent Unable
Item
inability to give informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain Untreated
Item
known brain metastases that haven't been treated
boolean
C0220650 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
bevacizumab
Item
bevacizumab treatment within 4 weeks prior to biopsy
boolean
C0796392 (UMLS CUI [1])
Anticoagulation Therapy | Exception Reversed Anticoagulation
Item
anticoagulation therapy, unless reversed at the time of biopsy
boolean
C0003281 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C2917126 (UMLS CUI [2,2])
Life Expectancy
Item
patients with a life expectancy of less than 6 months
boolean
C0023671 (UMLS CUI [1])
Prior Chemotherapy Platinum-Based Triple-Negative Breast Cancer
Item
prior treatment with platinum-based chemotherapy for tnbc
boolean
C1514457 (UMLS CUI [1,1])
C1514162 (UMLS CUI [1,2])
C2348819 (UMLS CUI [1,3])