Mild hypertension untreated | Moderate hypertension untreated | Hypertension, mild | Hypertension, moderate | Antihypertensive therapy
Item
patients with mild-to-moderate hypertension, untreated or currently taking antihypertensive therapy.
boolean
C3276943 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C1969581 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C3276943 (UMLS CUI [3])
C1969581 (UMLS CUI [4])
C0585941 (UMLS CUI [5])
Patients Treated | Antihypertensive therapy | Sitting systolic blood pressure mean | Randomization Visit | Visit preceding
Item
treated patients (using antihypertensive treatments within 4 weeks prior to visit 1) must have an mssbp ≥ 150 mmhg and < 180 mmhg at the randomization visit (visit 201) and mssbp ≥140 mmhg < 180 mmhg at the visit immediately proceeding visit 201 (visit 102 or 103).
boolean
C0030705 (UMLS CUI [1,1])
C1522326 (UMLS CUI [1,2])
C0585941 (UMLS CUI [2])
C1319893 (UMLS CUI [3,1])
C0444504 (UMLS CUI [3,2])
C0034656 (UMLS CUI [4,1])
C0008952 (UMLS CUI [4,2])
C0008952 (UMLS CUI [5,1])
C0332152 (UMLS CUI [5,2])
Patients untreated | Essential Hypertension Newly Diagnosed | History of hypertension | Sitting systolic blood pressure mean
Item
untreated patients (newly diagnosed with essential hypertension or having a history of hypertension but have not been taking any antihypertensive drugs for at least 4 weeks prior to visit 1) must have an mssbp ≥ 150 mmhg and < 180 mmhg at both visit 1 and visit 201.
boolean
C0030705 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0085580 (UMLS CUI [2,1])
C1518321 (UMLS CUI [2,2])
C0455527 (UMLS CUI [3])
C1319893 (UMLS CUI [4,1])
C0444504 (UMLS CUI [4,2])
Difference Sitting systolic blood pressure mean | Randomization Visit | Visit preceding
Item
patients must have an absolute difference of ≤15 mmhg in mssbp between visit 201 and the immediately preceding visit;
boolean
C1705242 (UMLS CUI [1,1])
C1319893 (UMLS CUI [1,2])
C0444504 (UMLS CUI [1,3])
C0034656 (UMLS CUI [2,1])
C0008952 (UMLS CUI [2,2])
C0008952 (UMLS CUI [3,1])
C0332152 (UMLS CUI [3,2])
Hypertension, severe | Sitting diastolic blood pressure mean | Sitting systolic blood pressure mean
Item
severe hypertension (msdbp ≥110 mmhg and/or mssbp ≥ 180 mmhg).
boolean
C4013784 (UMLS CUI [1])
C1319894 (UMLS CUI [2,1])
C0444504 (UMLS CUI [2,2])
C1319893 (UMLS CUI [3,1])
C0444504 (UMLS CUI [3,2])
Angioedema Drug-induced | Angioedema
Item
history of angioedema, drug-related or otherwise, as reported by the patient.
boolean
C0002994 (UMLS CUI [1,1])
C0458082 (UMLS CUI [1,2])
C0002994 (UMLS CUI [2])
Secondary hypertension | Parenchymal renal hypertension | Hypertension, Renovascular | Unilateral renal artery stenosis | Bilateral renal artery stenosis | Aortic coarctation | Conn Syndrome | Cushing's disease | Pheochromocytoma | Polycystic Kidney Diseases | Hypertensive disease Drug-induced
Item
history or evidence of a secondary form of hypertension, including but not limited to any of the following: renal parenchymal hypertension, renovascular hypertension (unilateral or bilateral renal artery stenosis), coarctation of the aorta, primary hyperaldosteronism, cushing's disease, pheochromocytoma, polycystic kidney disease, and drug-induced hypertension.
boolean
C0155616 (UMLS CUI [1])
C0264649 (UMLS CUI [2])
C0020545 (UMLS CUI [3])
C0856759 (UMLS CUI [4])
C0856760 (UMLS CUI [5])
C0003492 (UMLS CUI [6])
C1384514 (UMLS CUI [7])
C0221406 (UMLS CUI [8])
C0031511 (UMLS CUI [9])
C0022680 (UMLS CUI [10])
C0020538 (UMLS CUI [11,1])
C0458082 (UMLS CUI [11,2])
Study Subject Participation Status | LCZ 696 Clinical Trial
Item
patients who previously entered a lcz696 study and had been randomized or enrolled into the active drug treatment epoch.
boolean
C2348568 (UMLS CUI [1])
C2933615 (UMLS CUI [2,1])
C0008976 (UMLS CUI [2,2])
Eligibility Criteria Study Protocol
Item
other protocol-defined inclusion/exclusion criteria may apply.
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])