Non-Small Cell Lung Carcinoma Advanced | EGFR Activating Mutation | EGFR exon 19 deletion | Point mutation in exon 21 (L858R)
Item
evidence of histo or cytopathology confirmed, advanced nsclc (with known histology) with the presence of egfr activating mutation (exon 19 deletion or the l858r mutation in exon 21).
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C2984891 (UMLS CUI [2])
C3889117 (UMLS CUI [3])
C3888903 (UMLS CUI [4])
EGFR Exon 20 Mutation | EGFR Activating Mutation | EGFR exon 19 deletion | Point mutation in exon 21 (L858R)
Item
it is acceptable for subjects with the presence of the exon 20 t790m mutation together with either egfr activating mutation (exon 19 deletion or the l858r mutation in exon 21) to be included in this study
boolean
C4289655 (UMLS CUI [1])
C2984891 (UMLS CUI [2])
C3889117 (UMLS CUI [3])
C3888903 (UMLS CUI [4])
Systemic therapy Complete | Disease Free Duration | Non-small cell lung cancer recurrent
Item
minimum of 12 months disease free interval between completion of systemic therapy and recurrence of nsclc
boolean
C1515119 (UMLS CUI [1,1])
C0205197 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0332296 (UMLS CUI [2,2])
C0449238 (UMLS CUI [2,3])
C0278517 (UMLS CUI [3])
Availability of Tissue specimen | Analysis
Item
adequate tissue sample must be available for central analyses.
boolean
C0470187 (UMLS CUI [1,1])
C1292533 (UMLS CUI [1,2])
C0002778 (UMLS CUI [2])
Renal function | Hematologic function | Liver function
Item
adequate renal, hematologic, liver function.
boolean
C0232804 (UMLS CUI [1])
C0221130 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
ECOG performance status
Item
ecog ps of 0-1.
boolean
C1520224 (UMLS CUI [1])
Measurable Disease Radiologic
Item
radiologically measurable disease.
boolean
C1513041 (UMLS CUI [1,1])
C0205483 (UMLS CUI [1,2])
Small cell carcinoma of lung | Carcinoid tumor of lung
Item
any evidence of mixed histology that includes elements of small cell or carcinoid lung cancer.
boolean
C0149925 (UMLS CUI [1])
C0280089 (UMLS CUI [2])
Mutation | Exception EGFR exon 19 deletion | Exception Point mutation in exon 21 (L858R) | EGFR Exon 20 Mutation | EGFR Exon 20 Mutation Absent
Item
any other mutation other than exon 19 deletion or l858r in exon 21, with or without the presence of the exon 20 t790m mutation.
boolean
C0026882 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C3889117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C3888903 (UMLS CUI [3,2])
C4289655 (UMLS CUI [4])
C4289655 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
Metastatic malignant neoplasm to brain | Metastatic Malignant Neoplasm to the Leptomeninges
Item
any history of brain mets or leptomeningeal mets.
boolean
C0220650 (UMLS CUI [1])
C1704231 (UMLS CUI [2])
Systemic therapy Non-Small Cell Lung Carcinoma Early stage | Systemic therapy Non-Small Cell Lung Carcinoma Advanced Locally | Systemic therapy Non-small cell lung cancer metastatic
Item
any previous anti-cancer systemic treatment of early, locally advanced, or metastatic nsclc.
boolean
C1515119 (UMLS CUI [1,1])
C0007131 (UMLS CUI [1,2])
C2363430 (UMLS CUI [1,3])
C1515119 (UMLS CUI [2,1])
C0007131 (UMLS CUI [2,2])
C0205179 (UMLS CUI [2,3])
C1517927 (UMLS CUI [2,4])
C1515119 (UMLS CUI [3,1])
C0278987 (UMLS CUI [3,2])
Disease Uncontrolled
Item
uncontrolled medical disorders.
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])