Squamous cell carcinoma of oropharynx | Patients Appropriate Operative Surgical Procedures
Item
patients must be diagnosed with oropharyngeal squamous cell carcinoma (scc) that are surgical candidates
boolean
C0280313 (UMLS CUI [1])
C0030705 (UMLS CUI [2,1])
C1548787 (UMLS CUI [2,2])
C0543467 (UMLS CUI [2,3])
Tumor excision Macroscopic Planned | Transoral Robotic Surgery Curative
Item
macroscopic resection of the tumor via tors must be planned with curative intent
boolean
C1299802 (UMLS CUI [1,1])
C0439806 (UMLS CUI [1,2])
C1301732 (UMLS CUI [1,3])
C2986516 (UMLS CUI [2,1])
C1276305 (UMLS CUI [2,2])
Steroid therapy Remaining Postoperative
Item
patient must be willing to remain on corticosteroid therapy for 4 days postoperatively
boolean
C0149783 (UMLS CUI [1,1])
C1527428 (UMLS CUI [1,2])
C0032790 (UMLS CUI [1,3])
Informed Consent
Item
ability to understand and the willingness to sign a written informed consent document
boolean
C0021430 (UMLS CUI [1])
Distant metastasis | Cancer Other
Item
patients with known distant metastases or other malignancies
boolean
C1269798 (UMLS CUI [1])
C1707251 (UMLS CUI [2])
Hypersensitivity Adrenal Cortex Hormones | Allergic Reaction Adrenal Cortex Hormones
Item
patients with a history of allergy or adverse reaction to corticosteroids
boolean
C0020517 (UMLS CUI [1,1])
C0001617 (UMLS CUI [1,2])
C1527304 (UMLS CUI [2,1])
C0001617 (UMLS CUI [2,2])
Diabetes Mellitus
Item
patients with a history of diabetes
boolean
C0011849 (UMLS CUI [1])
Fasting blood glucose measurement capillary
Item
patients with fasting capillary blood glucose of > 140 on the day of surgery
boolean
C0428568 (UMLS CUI [1,1])
C0006901 (UMLS CUI [1,2])
Adrenal Cortex Hormones chronic
Item
patients on chronic corticosteroids
boolean
C0001617 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
Alcoholic Intoxication, Chronic | Alcoholic Beverages Quantity Daily
Item
chronic alcohol abuse (> 6 alcoholic beverages daily)
boolean
C0001973 (UMLS CUI [1])
C0001967 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0332173 (UMLS CUI [2,3])
Severe pain chronic | Narcotics High dose | Oxycodone Daily Dose | Equivalent Daily Dose | Status pre- Cancer diagnosis
Item
patients with a history of severe chronic pain on high dose narcotics (> 25 mg of oxycodone or equivalent daily) preceding diagnosis of cancer
boolean
C0278140 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0027415 (UMLS CUI [2,1])
C0444956 (UMLS CUI [2,2])
C0030049 (UMLS CUI [3,1])
C2348070 (UMLS CUI [3,2])
C0205163 (UMLS CUI [4,1])
C2348070 (UMLS CUI [4,2])
C0332152 (UMLS CUI [5,1])
C0920688 (UMLS CUI [5,2])
CYP3A4 Inhibitors | CYP3A4 Inducers | Protease Inhibitors | Ritonavir | Nelfinavir | Clarithromycin | Ketoconazole | Fluconazole | Verapamil | Diltiazem | Carbamazepine | Phenytoin | Phenobarbital | Rifampin | efavirenz | Nevirapine
Item
patients taking significant cytochrome p450 family 3, subfamily a, polypeptide 4 (cyp3a4) inhibitors or inducers, i.e. protease inhibitors (ritonavir, nelfinavir, etc), clarithromycin, ketoconazole, fluconazole, verapamil, diltiazem, carbamazepine, phenytoin, phenobarbital, rifampin, efavirenz, nevirapine
boolean
C3850053 (UMLS CUI [1])
C3850041 (UMLS CUI [2])
C0033607 (UMLS CUI [3])
C0292818 (UMLS CUI [4])
C0525005 (UMLS CUI [5])
C0055856 (UMLS CUI [6])
C0022625 (UMLS CUI [7])
C0016277 (UMLS CUI [8])
C0042523 (UMLS CUI [9])
C0012373 (UMLS CUI [10])
C0006949 (UMLS CUI [11])
C0031507 (UMLS CUI [12])
C0031412 (UMLS CUI [13])
C0035608 (UMLS CUI [14])
C0674428 (UMLS CUI [15])
C0132326 (UMLS CUI [16])
Investigational New Drugs | Investigational New Drugs Scheduled
Item
patients who have received any investigational medication within 6 weeks of enrollment, or who are scheduled to receive an investigational drug during the course of the study
boolean
C0013230 (UMLS CUI [1])
C0013230 (UMLS CUI [2,1])
C0205539 (UMLS CUI [2,2])
Complex head and neck surgery In addition to Transoral Robotic Surgery | Requirement Free flap Reconstruction
Item
patients who will undergo complex head and neck surgery in addition to the tors procedure requiring reconstruction with a free flap
boolean
C1512343 (UMLS CUI [1,1])
C0439855 (UMLS CUI [1,2])
C0332287 (UMLS CUI [1,3])
C2986516 (UMLS CUI [1,4])
C1514873 (UMLS CUI [2,1])
C0441031 (UMLS CUI [2,2])
C0524865 (UMLS CUI [2,3])
Head and neck surgery Affecting Deglutition | Head and neck surgery Affecting Voice | Head and neck surgery Affecting Speech | Radiation therapy to the head and neck
Item
patients who have had any previous head and neck surgery that has affected swallowing, voice or speech or who have had previous radiation to the head or neck
boolean
C1512343 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0011167 (UMLS CUI [1,3])
C1512343 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0042939 (UMLS CUI [2,3])
C1512343 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0037817 (UMLS CUI [3,3])
C4540910 (UMLS CUI [4])
Medical condition Affecting Cognition | Medical condition Affecting Speech | Medical condition Affecting Deglutition | Condition Neurological Affecting Cognition | Condition Neurological Affecting Speech | Condition Neurological Affecting Deglutition | Cerebrovascular accident | Neurodegenerative Disorders | Neuromuscular Diseases | Craniocerebral Trauma
Item
patients who have any confounding medical or neurological conditions that have the potential to affect cognition, speech or swallowing function; i.e. stroke, neurodegenerative disease, neuromuscular movement disorders, head injury, etcetera
boolean
C3843040 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0009240 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0037817 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0011167 (UMLS CUI [3,3])
C0348080 (UMLS CUI [4,1])
C0205494 (UMLS CUI [4,2])
C0392760 (UMLS CUI [4,3])
C0009240 (UMLS CUI [4,4])
C0348080 (UMLS CUI [5,1])
C0205494 (UMLS CUI [5,2])
C0392760 (UMLS CUI [5,3])
C0037817 (UMLS CUI [5,4])
C0348080 (UMLS CUI [6,1])
C0205494 (UMLS CUI [6,2])
C0392760 (UMLS CUI [6,3])
C0011167 (UMLS CUI [6,4])
C0038454 (UMLS CUI [7])
C0524851 (UMLS CUI [8])
C0027868 (UMLS CUI [9])
C0018674 (UMLS CUI [10])
Mental disorder Limiting Protocol Compliance | Social situation Limiting Protocol Compliance
Item
psychiatric illness/social situations that would limit compliance with study requirements
boolean
C0004936 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0748872 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
Patients Excluded | Study Subject Participation Status Observation allowed
Item
excluded patients will be allowed to participate in the trial on an observational basis only
boolean
C0030705 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C2348568 (UMLS CUI [2,1])
C0302523 (UMLS CUI [2,2])
C0683607 (UMLS CUI [2,3])