Heart failure with normal ejection fraction
Item
individual is diagnosed with heart failure with a normal lv ejection fraction. the diagnosis of hfnef requires the following conditions to be satisfied:
boolean
C2960127 (UMLS CUI [1])
Sign or Symptom Heart failure
Item
signs or symptoms of heart failure;
boolean
C3540840 (UMLS CUI [1,1])
C0018801 (UMLS CUI [1,2])
Normal left ventricular systolic function | Left ventricular systolic dysfunction Mild | Left ventricular ejection fraction
Item
normal or mildly abnormal systolic lv function (lvef ≥ 50%);
boolean
C3266756 (UMLS CUI [1])
C1277187 (UMLS CUI [2,1])
C2945599 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3])
Left ventricular diastolic dysfunction
Item
evidence of diastolic lv dysfunction.
boolean
C1273070 (UMLS CUI [1])
Hypertensive disease WHO classification | Systolic Pressure | Diastolic blood pressure | Antihypertensive Agents Quantity | Blood pressure ambulatory
Item
individual should fulfill the diagnostic who criteria for hypertension: sbp > 140 mmhg and/or dbp > 90 mmhg, and is treated with at least 2 antihypertensive drugs. this treatment is expected to be maintained for at least 6 months. using this regimen the blood pressure should be adequately controlled (< 140/90mmhg by 24 hour ambulatory bp measurement).
boolean
C0020538 (UMLS CUI [1,1])
C4267671 (UMLS CUI [1,2])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
C0003364 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C0855316 (UMLS CUI [5])
Pharmacotherapy Stable Heart failure with normal ejection fraction
Item
individual is adhering to a stable drug regimen hfnef, with no changes for a minimum of 2 weeks prior to enrollment, and which is expected to be maintained for at least 6 months.
boolean
C0013216 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C2960127 (UMLS CUI [1,3])
Age
Item
individual is ≥ 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Secondary hypertension
Item
known secondary cause of hypertension
boolean
C0155616 (UMLS CUI [1])
Anatomy Ineligible Renal artery denervation
Item
anatomy not eligible for renal denervation
boolean
C1384516 (UMLS CUI [1,1])
C1512714 (UMLS CUI [1,2])
C3544270 (UMLS CUI [1,3])
Heart Failure, Systolic | Left ventricular ejection fraction
Item
systolic heart failure (lvef < 50%)
boolean
C1135191 (UMLS CUI [1])
C0428772 (UMLS CUI [2])
Renal function GFR estimation by MDRD
Item
individual has an estimated glomerular filtration rate (egfr) of < 30ml/min/1.73m2, using the mdrd calculation.
boolean
C2170215 (UMLS CUI [1])
Medical condition Serious compromises Patient safety | Medical condition Serious compromises Clinical Trial | Peripheral Vascular Disease | Aortic Aneurysm, Abdominal | Blood Coagulation Disorders | Thrombocytopenia | Hemophilia | Anemia | Cardiac Arrhythmia | Atrial Fibrillation
Item
individual has any serious medical condition, which in the opinion of the investigator, may adversely affect the safety and/or effectiveness of the participant or the study (i.e., patients with clinically significant peripheral vascular disease, abdominal aortic aneurysm, bleeding disorders such as thrombocytopenia, haemophilia, significant anaemia, or arrhythmias such as atrial fibrillation).
boolean
C3843040 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C2945640 (UMLS CUI [1,3])
C1113679 (UMLS CUI [1,4])
C3843040 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C2945640 (UMLS CUI [2,3])
C0008976 (UMLS CUI [2,4])
C0085096 (UMLS CUI [3])
C0162871 (UMLS CUI [4])
C0005779 (UMLS CUI [5])
C0040034 (UMLS CUI [6])
C0684275 (UMLS CUI [7])
C0002871 (UMLS CUI [8])
C0003811 (UMLS CUI [9])
C0004238 (UMLS CUI [10])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
individual is pregnant, nursing or planning to be pregnant.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])