Informed Consent
Item
participant is willing and able to give informed consent for participation in the study.
boolean
C0021430 (UMLS CUI [1])
Age
Item
male or female, aged 18 years or above.
boolean
C0001779 (UMLS CUI [1])
Requirement Cardiac Surgery elective
Item
requiring elective cardiac surgery.
boolean
C1514873 (UMLS CUI [1,1])
C0018821 (UMLS CUI [1,2])
C0439608 (UMLS CUI [1,3])
Protocol Compliance
Item
able (in the investigators' opinion) and willing to comply with all study requirements.
boolean
C0525058 (UMLS CUI [1])
Study Subject Participation Status Willing
Item
willing to allow his or her general practitioner and consultant, if appropriate, to be notified of participation in the study.
boolean
C2348568 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
Age
Item
age>85yrs
boolean
C0001779 (UMLS CUI [1])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
female participant who is pregnant, lactating or planning pregnancy during the course of the study.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Childbearing Potential Contraceptive methods Absent | Contraceptives, Oral | Intrauterine Devices
Item
women of child-bearing potential without appropriate contraceptive measures. these include oral contraceptive pills, intrauterine contraceptive devices etc
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0009905 (UMLS CUI [2])
C0021900 (UMLS CUI [3])
Hepatobiliary disease Obstructive | Liver disease Serious | Alanine aminotransferase increased Preoperative | Alcohol abuse
Item
history of obstructive hepatobiliary disease or other serious hepatic disease or pre-operative alt >2-fold the upper limit of normal or alcohol abuse
boolean
C0267792 (UMLS CUI [1,1])
C0549186 (UMLS CUI [1,2])
C0023895 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
C0151905 (UMLS CUI [3,1])
C0445204 (UMLS CUI [3,2])
C0085762 (UMLS CUI [4])
Creatinine measurement, serum
Item
creatinine >200 umol/l
boolean
C0201976 (UMLS CUI [1])
Hypothyroidism Untreated
Item
untreated hypothyroidism
boolean
C0020676 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
Family history Hereditary muscle disorders
Item
family history of hereditary muscle disorders
boolean
C0241889 (UMLS CUI [1,1])
C0852407 (UMLS CUI [1,2])
Intolerance to Statins | Muscle Toxicity | Fibrates | Statins
Item
known intolerance to statins or history of muscle toxicity with fibrates or statins.
boolean
C1744706 (UMLS CUI [1,1])
C0360714 (UMLS CUI [1,2])
C0026845 (UMLS CUI [2,1])
C0600688 (UMLS CUI [2,2])
C1449704 (UMLS CUI [3])
C0360714 (UMLS CUI [4])
Fibrates | Niacin | Cytochrome P-450 Enzyme Inhibitors Strong | P-Glycoprotein Inhibitors Strong | Cyclosporine | Azole antifungal | Itraconazole | Ketoconazole | Macrolide Antibiotics | Erythromycin | Clarithromycin | Protease Inhibitors | nefazodone | Verapamil | Amiodarone | GRAPEFRUIT JUICE Large amount | Anti-Arrhythmia Agents | Exception Adrenergic beta-1 Receptor Antagonists
Item
ongoing use of fibrates, niacin or of agents that are strong inhibitors of cytochrome p-450 or the p-glycoprotein within a month preceding randomization (cyclosporine, azole antifungals, such as itraconazole and ketoconazole, macrolide antibiotics, such as erythromycin and clarithromycin, protease inhibitors, nefazodone, verapamil, amiodarone or large quantity of grapefruit juice (≥ 1l/day) patients on treatment with anti arrhythmic agents, other than beta-adrenergic receptor blockers.
boolean
C1449704 (UMLS CUI [1])
C0027996 (UMLS CUI [2])
C3850070 (UMLS CUI [3,1])
C0442821 (UMLS CUI [3,2])
C3500483 (UMLS CUI [4,1])
C0442821 (UMLS CUI [4,2])
C0010592 (UMLS CUI [5])
C0360363 (UMLS CUI [6])
C0064113 (UMLS CUI [7])
C0022625 (UMLS CUI [8])
C0003240 (UMLS CUI [9])
C0014806 (UMLS CUI [10])
C0055856 (UMLS CUI [11])
C0033607 (UMLS CUI [12])
C0068485 (UMLS CUI [13])
C0042523 (UMLS CUI [14])
C0002598 (UMLS CUI [15])
C0452456 (UMLS CUI [16,1])
C3869890 (UMLS CUI [16,2])
C0003195 (UMLS CUI [17])
C1705847 (UMLS CUI [18,1])
C0304516 (UMLS CUI [18,2])
Terminal illness | Patient Inappropriate Placebo
Item
participant who is terminally ill or is inappropriate for placebo medication.
boolean
C0679247 (UMLS CUI [1])
C0030705 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C1696465 (UMLS CUI [2,3])