Age
Item
male or female patients 18 years or older.
boolean
C0001779 (UMLS CUI [1])
Diffuse Large B-Cell Lymphoma TNM clinical staging | Exception Germinal Center B-Cell Type
Item
newly diagnosed non-gcb subtype of dlbcl (stage ii, iii or iv).
boolean
C0079744 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C1333295 (UMLS CUI [2,2])
Measurable Disease Site Quantity
Item
at least 1 measurable site of disease.
boolean
C1513041 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Postmenopausal state | Female Sterilization | Gender Sexual Abstinence | Gender Sexually active Contraceptive methods | Gender Pregnancy test negative
Item
female subjects must be postmenopausal (for at least 6 months), surgically sterile, abstinent, or, if sexually active, be practicing an effective method of birth control before entry and throughout the study; and have a negative pregnancy test at screening.
boolean
C0232970 (UMLS CUI [1])
C0015787 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0036899 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4,1])
C0241028 (UMLS CUI [4,2])
C0700589 (UMLS CUI [4,3])
C0079399 (UMLS CUI [5,1])
C0427780 (UMLS CUI [5,2])
Gender Barrier Contraception Double
Item
male subjects must agree to use a double barrier method of birth control
boolean
C0079399 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C0205173 (UMLS CUI [1,3])
Velcade
Item
prior treatment with velcade.
boolean
C1174739 (UMLS CUI [1])
Therapeutic radiology procedure Extended Lymphoma | Chemotherapy Extended Lymphoma
Item
prior extended radiotherapy or chemotherapy for lymphoma
boolean
C1522449 (UMLS CUI [1,1])
C0231448 (UMLS CUI [1,2])
C0024299 (UMLS CUI [1,3])
C0392920 (UMLS CUI [2,1])
C0231448 (UMLS CUI [2,2])
C0024299 (UMLS CUI [2,3])
Doxorubicin Dosage
Item
more than 150 mg/m2 of prior doxorubicin
boolean
C0013089 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
Major surgery
Item
major surgery within 3 weeks of study.
boolean
C0679637 (UMLS CUI [1])
Peripheral Neuropathy CTCAE grades | Neuralgia CTCAE grades
Item
peripheral neuropathy or neuralgia of grade 2 or worse.
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C0027796 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
Central nervous system lymphoma
Item
active cns lymphoma
boolean
C0742472 (UMLS CUI [1])
Malignant Neoplasms | Cancer treatment | Exception Non-Hodgkin Lymphoma
Item
diagnosed or treated for a malignancy other than nhl, with some exceptions
boolean
C0006826 (UMLS CUI [1])
C0920425 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0024305 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Sepsis
Item
active systemic infection
boolean
C0243026 (UMLS CUI [1])
HIV Infection Suspected | AIDS Suspected
Item
documented of suspected human immunodeficiency virus (hiv)/aids
boolean
C0019693 (UMLS CUI [1,1])
C0750491 (UMLS CUI [1,2])
C0001175 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
Cardiovascular Disease Uncontrolled | Cardiovascular Disease Severe
Item
uncontrolled or severe cardiovascular disease
boolean
C0007222 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0007222 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Hypersensitivity Investigational New Drugs | Intolerance to Investigational New Drugs
Item
known allergies, hypersensitivity or intolerance to study drugs
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C1744706 (UMLS CUI [2,1])
C0013230 (UMLS CUI [2,2])
Medical condition Interferes with Clinical Trial
Item
serious medical condition that could interfere with study
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0008976 (UMLS CUI [1,3])
Investigational New Drugs
Item
concurrent treatment with another investigational agent
boolean
C0013230 (UMLS CUI [1])