Non-Small Cell Lung Carcinoma TNM clinical staging
Item
histologically or cytologically confirmed diagnosis of metastatic stage iv nsclc
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Measurable lesion Quantity | Assessment Using Standard Technique
Item
have at least 1 measurable lesion whose presence is assessable using standard techniques by response evaluation criteria in solid tumors (recist version 1.1)
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1516048 (UMLS CUI [2,1])
C1524063 (UMLS CUI [2,2])
C1442989 (UMLS CUI [2,3])
C0449851 (UMLS CUI [2,4])
EGFR gene mutation Associated with Hypersensitivity EGFR Tyrosine Kinase inhibitor | EGFR G719X | EGFR Exon 19 Deletion Mutation | EGFR L858R | EGFR L861Q
Item
have molecular evidence of an epidermal growth factor receptor mutation (egfrmt) known to be associated with egfr tyrosine kinase inhibitor (tki) drug sensitivity (g719x, exon 19 deletion, l858r, l861q)
boolean
C3266992 (UMLS CUI [1,1])
C0332281 (UMLS CUI [1,2])
C0020517 (UMLS CUI [1,3])
C1443775 (UMLS CUI [1,4])
C3830332 (UMLS CUI [2])
C4289657 (UMLS CUI [3])
C3274204 (UMLS CUI [4])
C3274186 (UMLS CUI [5])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of ≤ 2
boolean
C1520224 (UMLS CUI [1])
Systemic Chemotherapy Absent NSCLC TNM clinical staging | Exception Neoadjuvant Therapy Early stage NSCLC | Exception Adjuvant therapy Early stage NSCLC | Exception Treatment completed
Item
haven't received any prior systemic chemotherapy for stage iv nsclc (unless received as neoadjuvant or adjuvant therapy for early-stage nsclc disease and completed therapy at least 6 months prior to enrollment)
boolean
C1883256 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0007131 (UMLS CUI [1,3])
C3258246 (UMLS CUI [1,4])
C1705847 (UMLS CUI [2,1])
C0600558 (UMLS CUI [2,2])
C2363430 (UMLS CUI [2,3])
C0007131 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C0677850 (UMLS CUI [3,2])
C2363430 (UMLS CUI [3,3])
C0007131 (UMLS CUI [3,4])
C1705847 (UMLS CUI [4,1])
C0580352 (UMLS CUI [4,2])
Availability of Tumor tissue sample | Block | Slide
Item
availability of adequate tumor material (block or slides)
boolean
C0470187 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C1533157 (UMLS CUI [2])
C1705201 (UMLS CUI [3])
Study Subject Participation Status | Investigational New Drugs | Investigational Medical Device
Item
are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational product or non-approved use of a drug or device
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C2346570 (UMLS CUI [3])
Study Subject Participation Status | Scientific investigation LY2875358
Item
have previously completed or withdrawn from this study or any other study investigating ly2875358
boolean
C2348568 (UMLS CUI [1])
C0683933 (UMLS CUI [2,1])
C2987383 (UMLS CUI [2,2])
Comorbidity Systemic Serious | Heart Disease
Item
have a serious concomitant systemic disorder or significant cardiac disease
boolean
C0009488 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0018799 (UMLS CUI [2])
Pneumonia, Interstitial | Interstitial lung fibrosis | Pleural effusion | Pericardial effusion | Ascites | Requirement Drainage Frequency
Item
have interstitial pneumonia or interstitial fibrosis of the lung or have pleural effusion, pericardial fluids or ascites, requiring drainage every other week or more frequently
boolean
C0206061 (UMLS CUI [1])
C3887486 (UMLS CUI [2])
C0032227 (UMLS CUI [3])
C0031039 (UMLS CUI [4])
C0003962 (UMLS CUI [5])
C1514873 (UMLS CUI [6,1])
C0013103 (UMLS CUI [6,2])
C0439603 (UMLS CUI [6,3])
Cancer Other | Exception Basal cell carcinoma | Exception Squamous cell carcinoma of skin | Exception Carcinoma in situ of uterine cervix | Exception Curative treatment Solid Neoplasm | Exception Recurrent disease Free Duration
Item
have a history of another malignancy except for basal or squamous cell skin cancer and/or in situ carcinoma of the cervix, or other solid tumors treated curatively and without evidence of recurrence for at least 3 years prior to the study
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C0280100 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0277556 (UMLS CUI [6,2])
C0332296 (UMLS CUI [6,3])
C0449238 (UMLS CUI [6,4])
Major surgery
Item
have major surgery less than 2 weeks prior to the initiation of study treatment therapy
boolean
C0679637 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])