Liver carcinoma intrahepatic unresectable | Liver mass Identifiable Radiography | Risk factors Known Malignant Neoplasm | Tumour marker increased | Other Coding | alpha-Fetoprotein | Clinical findings
Item
1. diagnosis of unresectable intrahepatic hcc. the histopathology confirmation criterion may be waived in patients with a radiographically identifiable liver mass, known laboratory or clinical risk factors for cancer or elevated tumor markers such as alphafetoprotein (afp)^21 and clinical findings. guidelines from the american association for the study of liver diseases (aasld) and the european association for the study of the liver (easl) describe in detail the approach and algorithm for diagnosing hcc.
boolean
C2239176 (UMLS CUI [1,1])
C1512948 (UMLS CUI [1,2])
C1519810 (UMLS CUI [1,3])
C0240225 (UMLS CUI [2,1])
C0205396 (UMLS CUI [2,2])
C0034571 (UMLS CUI [2,3])
C0035648 (UMLS CUI [3,1])
C0205309 (UMLS CUI [3,2])
C0006826 (UMLS CUI [3,3])
C0876999 (UMLS CUI [4])
C3846158 (UMLS CUI [5])
C0002210 (UMLS CUI [6])
C0037088 (UMLS CUI [7])
ECOG performance status
Item
2. eastern cooperative oncology group (ecog) performance status score 0 - 1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
3. life expectancy >/= 3 months
boolean
C0023671 (UMLS CUI [1])
Prior radiation therapy | Prior surgery | Prior Chemotherapy
Item
4. > 4 weeks since prior radiation, surgery or chemotherapy
boolean
C0279134 (UMLS CUI [1])
C0455610 (UMLS CUI [2])
C1514457 (UMLS CUI [3])
Informed Consent
Item
5. able to comprehend and provide written informed consent in accordance with institutional and federal guidelines.
boolean
C0021430 (UMLS CUI [1])
Liver Dysfunction Laboratory test finding Pretreatment | Aspartate aminotransferase increased | Alanine aminotransferase increased | Serum total bilirubin measurement | Exception Infusion Segmental Planned
Item
1. any pre-treatment laboratory findings within 15 days of treatment demonstrating liver dysfunction: • ast (serum glutamic-oxalacetic transaminase - sgot) or alt (serum glutamic-pyruvic transaminase - sgpt) > 5 times upper normal limit (unl) • serum bilirubin > 2.0 mg/dl (unless segmental infusion is planned)
boolean
C0086565 (UMLS CUI [1,1])
C0587081 (UMLS CUI [1,2])
C3539076 (UMLS CUI [1,3])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
C1705847 (UMLS CUI [5,1])
C0574032 (UMLS CUI [5,2])
C0205122 (UMLS CUI [5,3])
C1301732 (UMLS CUI [5,4])
Medical contraindication Angiography | Medical contraindication Catheterization hepatic artery | Contrast media allergy Severe | Intolerance to Contrast Media | Narcotic allergy Severe | Intolerance to Narcotics | Sedative allergy Severe | Intolerance to Sedatives | Atropine allergy Severe | Intolerance to Atropine | Bleeding tendency | Peripheral Vascular Disease Severe Excludes Catheterization
Item
2. any contraindications to angiography and hepatic artery catheterization such as: history of severe allergy or intolerance to any contrast media, narcotics, sedatives, or atropine that cannot be corrected or premedicated; bleeding diathesis, not correctable by usual forms of therapy; severe peripheral vascular disease that would preclude catheterization.
boolean
C1301624 (UMLS CUI [1,1])
C0002978 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C4031927 (UMLS CUI [2,2])
C0570562 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C1744706 (UMLS CUI [4,1])
C0009924 (UMLS CUI [4,2])
C0746753 (UMLS CUI [5,1])
C0205082 (UMLS CUI [5,2])
C1744706 (UMLS CUI [6,1])
C0027415 (UMLS CUI [6,2])
C0570793 (UMLS CUI [7,1])
C0205082 (UMLS CUI [7,2])
C1744706 (UMLS CUI [8,1])
C0036557 (UMLS CUI [8,2])
C0570993 (UMLS CUI [9,1])
C0205082 (UMLS CUI [9,2])
C1744706 (UMLS CUI [10,1])
C0004259 (UMLS CUI [10,2])
C1458140 (UMLS CUI [11])
C0085096 (UMLS CUI [12,1])
C0205082 (UMLS CUI [12,2])
C0332196 (UMLS CUI [12,3])
C0007430 (UMLS CUI [12,4])
Irradiation of lung Dose Treatment
Item
3. evidence of potential delivery of greater than 16.5 mci (30 gy absorbed dose) of radiation to the lungs in a single treatment
boolean
C2169076 (UMLS CUI [1,1])
C0034524 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
Pulmonary Insufficiency
Item
4. clinical evidence of pulmonary insufficiency
boolean
C0034088 (UMLS CUI [1])
Tc 99m MAA Flow Stomach | Tc 99m MAA Flow Duodenum
Item
5. evidence of any detectable technetium-99 macroaggregated albumin (tc-99m maa) flow to the stomach or duodenum, after application of established angiographic techniques to stop or mitigate such flow.
boolean
C0039415 (UMLS CUI [1,1])
C0806140 (UMLS CUI [1,2])
C0038351 (UMLS CUI [1,3])
C0039415 (UMLS CUI [2,1])
C0806140 (UMLS CUI [2,2])
C0013303 (UMLS CUI [2,3])
Complete obstruction Main portal vein
Item
6. complete occlusion of the main portal vein.
boolean
C0001168 (UMLS CUI [1,1])
C1183135 (UMLS CUI [1,2])
Disease Extrahepatic | Outcome Life Threatening
Item
7. significant extrahepatic disease representing an imminent life-threatening outcome
boolean
C0012634 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
C1274040 (UMLS CUI [2,1])
C2826244 (UMLS CUI [2,2])
Communicable Disease Uncontrolled
Item
8. active uncontrolled infection.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Illness Significant | Mental disorder Significant
Item
9. significant underlying medical or psychiatric illness.
boolean
C0221423 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0004936 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Comorbidity Excludes Therasphere | Comorbidity At risk Patient
Item
10. co-morbid disease of condition that would preclude safe delivery of therasphere treatment or, in the judgment of the physician, place the patient at undue risk
boolean
C0009488 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C1135147 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C0030705 (UMLS CUI [2,3])
Pregnancy
Item
11. pregnancy
boolean
C0032961 (UMLS CUI [1])
Tumor type Infiltrating Imaging | Tumor % volume Liver | Tumor Nodule Numerous | Albumin measurement | Complete obstruction Main portal vein
Item
12. tumor type demonstrated on imaging to be infiltrative, tumor volume > 70% of the target liver volume, or tumor nodules too numerous to count, or tumor volume > 50% combined with an albumin < 3 g/dl, or complete occlusion of the main portal vein.
boolean
C4263544 (UMLS CUI [1,1])
C0332448 (UMLS CUI [1,2])
C0011923 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C1690016 (UMLS CUI [2,2])
C0023884 (UMLS CUI [2,3])
C0027651 (UMLS CUI [3,1])
C0028259 (UMLS CUI [3,2])
C0439064 (UMLS CUI [3,3])
C0201838 (UMLS CUI [4])
C0001168 (UMLS CUI [5,1])
C1183135 (UMLS CUI [5,2])