Age
Item
1. ≥ 18 years of age (no upper age limit)
boolean
C0001779 (UMLS CUI [1])
Squamous cell carcinoma of oropharynx TNM clinical staging
Item
2. t0-3, n0 to n2c, m0 squamous cell carcinoma of the oropharynx
boolean
C0280313 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Squamous cell carcinoma HPV Positive | Squamous cell carcinoma p16 Positive
Item
3. biopsy proven squamous cell carcinoma that is hpv and/or p16 positive
boolean
C0007137 (UMLS CUI [1,1])
C4288937 (UMLS CUI [1,2])
C0007137 (UMLS CUI [2,1])
C4289892 (UMLS CUI [2,2])
Smoking cigarettes: ____ pack-years history | Abstinence from smoking Duration
Item
4. ≤ 10 pack-years smoking history or ≤ 30 pack-years smoking history with ≥ 5 years abstinence from smoking
boolean
C2230126 (UMLS CUI [1])
C2042177 (UMLS CUI [2,1])
C0449238 (UMLS CUI [2,2])
Hematogenous metastases status Negative
Item
5. radiologic confirmation of the absence of hematogenous metastasis within 12 weeks prior to registration
boolean
C0475457 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
ECOG performance status
Item
6. ecog performance status 0-1
boolean
C1520224 (UMLS CUI [1])
CBC with differential | Bone Marrow function | Platelet Count measurement | Hemoglobin measurement
Item
7. cbc/differential obtained within 8 weeks prior to registration, with adequate bone marrow function defined as follows: platelets ≥ 100,000 cells/mm3; hemoglobin ≥ 8.0 g/dl.
boolean
C0545131 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
C0032181 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
Renal function | Liver function | Creatinine measurement, serum | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
8. adequate renal and hepatic function within 4 weeks prior to registration, defined as follows: serum creatinine < 2.0 mg/dl; total bilirubin < 2 x the institutional uln; ast or alt < 3 x the institutional uln.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0201976 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
C0201899 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
Childbearing Potential Serum pregnancy test negative
Item
9. negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential
boolean
C3831118 (UMLS CUI [1,1])
C0430061 (UMLS CUI [1,2])
Childbearing Potential Sexually active Contraceptive methods | Gender Sexually active Contraceptive methods
Item
10. women of childbearing potential and male participants who are sexually active must practice adequate contraception during treatment and for 6 weeks following treatment.
boolean
C3831118 (UMLS CUI [1,1])
C0241028 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
C0079399 (UMLS CUI [2,1])
C0241028 (UMLS CUI [2,2])
C0700589 (UMLS CUI [2,3])
Protocol Compliance
Item
11. patients must be deemed able to comply with the treatment plan and follow-up schedule.
boolean
C0525058 (UMLS CUI [1])
Informed Consent
Item
12. patients must provide study specific informed consent prior to study entry
boolean
C0021430 (UMLS CUI [1])
Radiotherapy to head and neck
Item
1. prior history of radiation therapy to the head and neck
boolean
C3888854 (UMLS CUI [1])
Malignant Head and Neck Neoplasm
Item
2. prior history of head and neck cancer.
boolean
C0278996 (UMLS CUI [1])
Disease unresectable | Node Immobile Physical Examination | Disease nodal Involving Carotid Arteries | Disease nodal Involving Carotid nerve | Radiography
Item
3. unresectable disease (e.g. immobile node on physical exam, nodal disease that radiographgically involves the carotid arteries, nerves)
boolean
C0012634 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C0746922 (UMLS CUI [2,1])
C0231441 (UMLS CUI [2,2])
C0031809 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0443268 (UMLS CUI [3,2])
C1314939 (UMLS CUI [3,3])
C0007272 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0443268 (UMLS CUI [4,2])
C1314939 (UMLS CUI [4,3])
C1282689 (UMLS CUI [4,4])
C0034571 (UMLS CUI [5])
Smokeless Tobacco Use Extensive | Marijuana Smoking Extensive
Item
4. extensive history of using smokeless tobacco products or marijuana defined as daily use >/= 5 years.
boolean
C4527315 (UMLS CUI [1,1])
C0205231 (UMLS CUI [1,2])
C0024810 (UMLS CUI [2,1])
C0205231 (UMLS CUI [2,2])
Comorbidity Severe | Angina, Unstable | Congestive heart failure Hospitalization Required | Transmural myocardial infarction | Bacterial Infection | Mycoses | Requirement Antibiotics Intravenous | COPD exacerbation | Respiration Disorder Hospitalization Required | Respiration Disorder Excludes Investigational Therapy | Hepatic Insufficiency Resulting in Icterus | Hepatic Insufficiency Resulting in Coagulation Defects | Neuropathy Pre-existing CTCAE Grades | Organ Transplantation
Item
5. severe, active co-morbidity, defined as follows: unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months; transmural myocardial infarction within the last 6 months; acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration; chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration; hepatic insufficiency resulting in clinical jaundice and/or coagulation defects (note, however, coagulation parameters are not required for entry into this protocol); pre-existing ≥ grade 2 neuropathy; prior organ transplant.
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0018802 (UMLS CUI [3,1])
C1708385 (UMLS CUI [3,2])
C1400513 (UMLS CUI [4])
C0004623 (UMLS CUI [5])
C0026946 (UMLS CUI [6])
C1514873 (UMLS CUI [7,1])
C0003232 (UMLS CUI [7,2])
C1522726 (UMLS CUI [7,3])
C0740304 (UMLS CUI [8])
C0035204 (UMLS CUI [9,1])
C1708385 (UMLS CUI [9,2])
C0035204 (UMLS CUI [10,1])
C0332196 (UMLS CUI [10,2])
C0949266 (UMLS CUI [10,3])
C1306571 (UMLS CUI [11,1])
C0332294 (UMLS CUI [11,2])
C0022346 (UMLS CUI [11,3])
C1306571 (UMLS CUI [12,1])
C0332294 (UMLS CUI [12,2])
C0005779 (UMLS CUI [12,3])
C0442874 (UMLS CUI [13,1])
C2347662 (UMLS CUI [13,2])
C1516728 (UMLS CUI [13,3])
C0029216 (UMLS CUI [14])
HIV Seropositivity
Item
6. known hiv positive.
boolean
C0019699 (UMLS CUI [1])