Age
Item
age 18 - 60 years, either gender
boolean
C0001779 (UMLS CUI [1])
Asthma Disease length | Requirement Adrenal Cortex Hormones by Inhalation High dose | Adrenergic beta-2 Receptor Agonists Active Long-term | Adrenergic beta-2 Receptor Agonists Absent | Symptoms Persistent | Requirement Adrenergic beta-Agonists Active short-term
Item
confirmed diagnosis of asthma for > 1 year as defined by bts guidelines, requiring treatment with high dose inhaled corticosteroids +/- long acting β2 agonists, with persisting symptoms requiring use of short-acting beta agonist therapy >3x/week.
boolean
C0004096 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C0001617 (UMLS CUI [2,2])
C0205535 (UMLS CUI [2,3])
C0444956 (UMLS CUI [2,4])
C2936789 (UMLS CUI [3,1])
C0205177 (UMLS CUI [3,2])
C0443252 (UMLS CUI [3,3])
C2936789 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C1457887 (UMLS CUI [5,1])
C0205322 (UMLS CUI [5,2])
C1514873 (UMLS CUI [6,1])
C0001644 (UMLS CUI [6,2])
C0205177 (UMLS CUI [6,3])
C0443303 (UMLS CUI [6,4])
Non-smoker | Former smoker Smoking cigarettes: ____ pack-years history
Item
never-smoker or ex-smoker, having stopped >1 year ago, with <10 pack year history.
boolean
C0337672 (UMLS CUI [1])
C0337671 (UMLS CUI [2,1])
C2230126 (UMLS CUI [2,2])
Comprehension Study Protocol | Informed Consent
Item
subject must understand the procedures of the study and agree to participation in the study by providing written informed consent
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Study Subject Fit Pulmonary function tests | Pulmonary function challenge test | Bronchoscopy
Item
subject considered fit enough to undergo lung function testing including provocation tests, and bronchoscopy.
boolean
C0681850 (UMLS CUI [1,1])
C0424576 (UMLS CUI [1,2])
C0024119 (UMLS CUI [1,3])
C1096110 (UMLS CUI [2])
C0006290 (UMLS CUI [3])
Study Subject Participation Status | Absence Participation Clinical Trial Other
Item
subject must not be participating in another clinical trial or have done so within the last 12 weeks.
boolean
C2348568 (UMLS CUI [1])
C0332197 (UMLS CUI [2,1])
C0679823 (UMLS CUI [2,2])
C0008976 (UMLS CUI [2,3])
C0205394 (UMLS CUI [2,4])
Oral steroid-dependent asthma | Symbicort Inhalant Product Regimen
Item
patients requiring regular maintenance oral steroids for their asthma, or those who are adhering to symbicort smart single inhaler regime.
boolean
C4510155 (UMLS CUI [1])
C3239267 (UMLS CUI [2,1])
C0040808 (UMLS CUI [2,2])
Pregnancy | HCG pregnancy test Positive | Pregnancy, Planned | Breast Feeding
Item
pregnancy (where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hcg laboratory test >5miu/ml), an intention to become pregnant or breast-feeding (lactating).
boolean
C0032961 (UMLS CUI [1])
C0546577 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C0032992 (UMLS CUI [3])
C0006147 (UMLS CUI [4])
Lung disease | Exception Asthma
Item
subjects with active lung disease other than asthma
boolean
C0024115 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0004096 (UMLS CUI [2,2])
Comorbidity Impact Interpretation Research results | Comorbidity Impact Study Subject Participation Status | Comorbidity Uncontrolled | Cor pulmonale | Nervous system disorder | Kidney Disease | Endocrine System Disease | Gastrointestinal Disease | Mental disorder | Liver disease | Hematological Disease
Item
significant medical (cardiopulmonary, neurological, renal, endocrine, gastrointestinal, psychiatric, hepatic or haematological)co-morbidity which in the view of the investigator could impact on the interpretation of results or participation in the trial, or which is uncontrolled with standard treatment.
boolean
C0009488 (UMLS CUI [1,1])
C4049986 (UMLS CUI [1,2])
C0459471 (UMLS CUI [1,3])
C0683954 (UMLS CUI [1,4])
C0009488 (UMLS CUI [2,1])
C4049986 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
C0009488 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0034072 (UMLS CUI [4])
C0027765 (UMLS CUI [5])
C0022658 (UMLS CUI [6])
C0014130 (UMLS CUI [7])
C0017178 (UMLS CUI [8])
C0004936 (UMLS CUI [9])
C0023895 (UMLS CUI [10])
C0018939 (UMLS CUI [11])
Study Subject Participation Status
Item
current participation in another clinical trial or previous participation within the last 12 weeks.
boolean
C2348568 (UMLS CUI [1])
Substance Use Disorders
Item
alcohol or active drug abuse.
boolean
C0038586 (UMLS CUI [1])
Allergen Immunotherapy
Item
ongoing allergen desensitisation therapy
boolean
C0162352 (UMLS CUI [1])
Use of Sedatives Regular | Use of Hypnotics Regular | Use of Tranquilizing Agents Regular
Item
regular use of sedatives, hypnotics, tranquilisers
boolean
C1524063 (UMLS CUI [1,1])
C0036557 (UMLS CUI [1,2])
C0205272 (UMLS CUI [1,3])
C1524063 (UMLS CUI [2,1])
C0020591 (UMLS CUI [2,2])
C0205272 (UMLS CUI [2,3])
C1524063 (UMLS CUI [3,1])
C0040614 (UMLS CUI [3,2])
C0205272 (UMLS CUI [3,3])
Malignant Neoplasms | Individual Cancer History
Item
cancer or previous history of cancer
boolean
C0006826 (UMLS CUI [1])
C1512706 (UMLS CUI [2])
Study Protocol Comprehension Unable
Item
inability to understand directions for dosing and study assessment.
boolean
C2348563 (UMLS CUI [1,1])
C0162340 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
Patient unavailable Emergency Situation
Item
inability to be contacted in case of emergency.
boolean
C1301818 (UMLS CUI [1,1])
C0013956 (UMLS CUI [1,2])