Subjects with severe and moderately severe hemophilia A (FVIII <= 2%). Certain FVIII mutation types (e.g., large multi-domain deletions, nonsense mutations, insertions/deletions/inversions that result in a premature stop codon, intron 22 inversions) can be used to corroborate a severe hemophilia A phenotype when laboratory assays show FVIII levels >= 1% because of rounding errors or carryover effect from a previous FVIII administration. A central laboratory FVIII assay is required to confirm subject eligibility.
Subjects with severe and moderately severe hemophilia A (FVIII <= 2%). Certain FVIII mutation types (e.g., large multi-domain deletions, nonsense mutations, insertions/deletions/inversions that result in a premature stop codon, intron 22 inversions) can be used to corroborate a severe hemophilia A phenotype when laboratory assays show FVIII levels >= 1% because of rounding errors or carryover effect from a previous FVIII administration. A central laboratory FVIII assay is required to confirm subject eligibility.
C1299393 (UMLS CUI 2011AA)
371924009 (SNOMED CT 2011_0131)
C0019069 (UMLS CUI 2011AA)
234440005 (SNOMED CT 2011_0131)
10016080 (MedDRA 14.1)
D66 (ICD-10-CM Version 2010)
286.0 (ICD-9-CM Version 2011)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C0015506 (UMLS CUI 2011AA)
278910002, 259736008 (SNOMED CT 2011_0131)
MTHU009422 (LOINC Version 232)
C0026882 (UMLS CUI 2011AA)
55446002 (SNOMED CT 2011_0131)
C0332307 (UMLS CUI 2011AA)
410657003 (SNOMED CT 2011_0131)
MTHU013727 (LOINC Version 232)
C0544885 (UMLS CUI 2011AA)
327671006 (SNOMED CT 2011_0131)
C0205252 (UMLS CUI 2011AA)
1090009 (SNOMED CT 2011_0131)
C0242611 (UMLS CUI 2011AA)
C0272322 (UMLS CUI 2011AA)
16872008 (SNOMED CT 2011_0131)
C0031437 (UMLS CUI 2011AA)
8116006 (SNOMED CT 2011_0131)
C1514873 (UMLS CUI 2011AA)
C1880016 (UMLS CUI 2011AA)
C0200399 (UMLS CUI 2011AA)
269819008 (SNOMED CT 2011_0131)