Breast Carcinoma
Item
histologically or cytologically confirmed carcinoma of the breast
boolean
C0678222 (UMLS CUI [1])
Advanced disease Locally | Neoplasm Metastasis | Appropriateness Cytotoxic Chemotherapy Systemic Single
Item
locally advanced and/or metastatic disease appropriate for systemic single cytotoxic chemotherapy
boolean
C0679246 (UMLS CUI [1,1])
C1517927 (UMLS CUI [1,2])
C0027627 (UMLS CUI [2])
C0814634 (UMLS CUI [3,1])
C0677881 (UMLS CUI [3,2])
C0205373 (UMLS CUI [3,3])
C0205171 (UMLS CUI [3,4])
Germline BRCA1 mutation Deleterious | Germline BRCA1 mutation Pathogenic | Germline BRCA2 mutation Deleterious | Germline BRCA2 mutation Pathogenic
Item
deleterious or pathogenic germline brca1 or brca2 mutation
boolean
C3845275 (UMLS CUI [1,1])
C1511022 (UMLS CUI [1,2])
C2985436 (UMLS CUI [1,3])
C3845275 (UMLS CUI [2,1])
C1511022 (UMLS CUI [2,2])
C3816499 (UMLS CUI [2,3])
C3845275 (UMLS CUI [3,1])
C1511024 (UMLS CUI [3,2])
C2985436 (UMLS CUI [3,3])
C3845275 (UMLS CUI [4,1])
C1511024 (UMLS CUI [4,2])
C3816499 (UMLS CUI [4,3])
Prior Chemotherapy Quantity | Therapeutic regimen Advanced disease Locally | Therapeutic regimen Neoplasm Metastasis
Item
no more than 2 prior chemotherapy-inclusive regimens for locally advanced and/or metastatic disease
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1276413 (UMLS CUI [2,1])
C0679246 (UMLS CUI [2,2])
C1517927 (UMLS CUI [2,3])
C1276413 (UMLS CUI [3,1])
C0027627 (UMLS CUI [3,2])
Prior Therapy Adjuvant | Prior Therapy Neoplasm Metastasis | taxane | Anthracyclines
Item
prior treatment with a taxane and/or anthracycline in the adjuvant or metastatic setting
boolean
C1514463 (UMLS CUI [1,1])
C1522673 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0027627 (UMLS CUI [2,2])
C0215136 (UMLS CUI [3])
C0282564 (UMLS CUI [4])
ECOG performance status
Item
ecog performance status ≤ 1
boolean
C1520224 (UMLS CUI [1])
Organ function
Item
have adequate organ function
boolean
C0678852 (UMLS CUI [1])
Prior Therapy | PARP Inhibitors
Item
prior treatment with a parp inhibitor
boolean
C1514463 (UMLS CUI [1])
C1882413 (UMLS CUI [2])
Prior Therapy Neoplasm Metastasis | Platinum | Adjuvant therapy | Neoadjuvant Therapy
Item
prior platinum treatment for metastatic disease. subjects who have received platinum in the adjuvant or neoadjuvant setting are eligible
boolean
C1514463 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0032207 (UMLS CUI [2])
C0677850 (UMLS CUI [3])
C0600558 (UMLS CUI [4])
CNS metastases CT scan | CNS metastases MRI scan | Exception Metastatic malignant neoplasm to brain Treated
Item
cns metastasis except adequately treated brain metastasis documented by baseline ct or mri scan that has not progressed since previous scans and that does not require corticosteroids for management of cns symptoms
boolean
C0686377 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2,1])
C0024485 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0220650 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
Malignant Neoplasms Previous | Exception Malignant Neoplasm Associated with BRCA | Malignant Neoplasms Previous Absent | Exception Carcinoma in situ of uterine cervix | Exception Skin carcinoma | Exception Definitive Treatment Malignant Neoplasm | Exception Recurrence Absent
Item
prior malignancy except for prior brca-associated cancer as long as there is no current evidence of the prior cancer, carcinoma in situ of the cervix or non-melanoma skin cancer, and a cancer diagnosed and definitively treated ≥5 years prior to study enrollment with no subsequent evidence of recurrence
boolean
C0006826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
C0332281 (UMLS CUI [2,3])
C0596223 (UMLS CUI [2,4])
C0006826 (UMLS CUI [3,1])
C0205156 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0699893 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C2986592 (UMLS CUI [6,2])
C0006826 (UMLS CUI [6,3])
C1705847 (UMLS CUI [7,1])
C0034897 (UMLS CUI [7,2])
C0332197 (UMLS CUI [7,3])
HIV Seropositivity | Hepatitis C virus | Hepatitis B Virus
Item
known to be hiv positive, active hepatitis c virus, or active hepatitis b virus
boolean
C0019699 (UMLS CUI [1])
C0220847 (UMLS CUI [2])
C0019169 (UMLS CUI [3])
Hypersensitivity Talazoparib Component
Item
known hypersensitivity to any of the components of talazoparib
boolean
C0020517 (UMLS CUI [1,1])
C4042960 (UMLS CUI [1,2])
C1705248 (UMLS CUI [1,3])