Adult | Gender | Recurrent disease Locoregional | Neoplasm Metastasis | Disease Inappropriate Curative treatment
Item
adult women with locoregionally recurrent or metastatic disease not amenable to curative therapy.
boolean
C0001675 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
C0277556 (UMLS CUI [3,1])
C1947913 (UMLS CUI [3,2])
C0027627 (UMLS CUI [4])
C0012634 (UMLS CUI [5,1])
C1548788 (UMLS CUI [5,2])
C1273390 (UMLS CUI [5,3])
Oestrogen receptor positive breast cancer
Item
confirmed diagnosis of er positive breast cancer
boolean
C2938924 (UMLS CUI [1])
Cancer treatment Systemic Absent | Advanced disease Estrogen receptor positive
Item
no prior systemic anti-cancer therapy for advanced er+ disease.
boolean
C0920425 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0679246 (UMLS CUI [2,1])
C0279754 (UMLS CUI [2,2])
Postmenopausal state
Item
postmenopausal women
boolean
C0232970 (UMLS CUI [1])
Measurable Disease | Bone Disease only
Item
measurable disease as per response evaluation criterion in solid tumors [recist] or bone-only disease
boolean
C1513041 (UMLS CUI [1])
C0005940 (UMLS CUI [2,1])
C0205171 (UMLS CUI [2,2])
ECOG performance status
Item
eastern cooperative oncology group [ecog] 0-2
boolean
C1520224 (UMLS CUI [1])
Organ function | Bone Marrow function
Item
adequate organ and marrow function
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
Tumor tissue sample Provide
Item
patient must agree to provide tumor tissue
boolean
C0475358 (UMLS CUI [1,1])
C1999230 (UMLS CUI [1,2])
Disease HER2 Positive
Item
confirmed diagnosis of her2 positive disease
boolean
C0012634 (UMLS CUI [1,1])
C2348909 (UMLS CUI [1,2])
Spread Visceral Symptomatic Advanced | At risk Complications Life Threatening
Item
patients with advanced, symptomatic, visceral spread that are at risk of life threatening complication in the short term
boolean
C0332261 (UMLS CUI [1,1])
C0442045 (UMLS CUI [1,2])
C0231220 (UMLS CUI [1,3])
C0205179 (UMLS CUI [1,4])
C1444641 (UMLS CUI [2,1])
C0009566 (UMLS CUI [2,2])
C2826244 (UMLS CUI [2,3])
CNS metastases Uncontrolled | CNS metastases Symptomatic
Item
known uncontrolled or symptomatic cns metastases
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
Adjuvant therapy Letrozole | Adjuvant therapy Anastrozole | Neoadjuvant Therapy Letrozole | Neoadjuvant Therapy Anastrozole | Treatment completed | Interval Disease Free
Item
prior (neo)adjuvant treatment with letrozole or anastrozole with dfi ≤ 12-months from completion of treatment.
boolean
C0677850 (UMLS CUI [1,1])
C0246421 (UMLS CUI [1,2])
C0677850 (UMLS CUI [2,1])
C0290883 (UMLS CUI [2,2])
C0600558 (UMLS CUI [3,1])
C0246421 (UMLS CUI [3,2])
C0600558 (UMLS CUI [4,1])
C0290883 (UMLS CUI [4,2])
C0580352 (UMLS CUI [5])
C1272706 (UMLS CUI [6,1])
C0012634 (UMLS CUI [6,2])
C0332296 (UMLS CUI [6,3])
CDK4 Inhibitor | CDK6 Inhibitor
Item
prior treatment with any cdk 4/6 inhibitor.
boolean
C0246957 (UMLS CUI [1,1])
C1999216 (UMLS CUI [1,2])
C0252132 (UMLS CUI [2,1])
C1999216 (UMLS CUI [2,2])