Gender | Adult
Item
female adult patients
boolean
C0079399 (UMLS CUI [1])
C0001675 (UMLS CUI [2])
Breast adenocarcinoma | Recurrent disease Locally Measurable | Neoplasm Metastasis Measurable | Recurrent disease Locally | Neoplasm Metastasis
Item
histologically or cytologically confirmed adenocarcinoma of the breast, with measurable or non-measurable locally recurrent or metastatic disease
boolean
C0858252 (UMLS CUI [1])
C0277556 (UMLS CUI [2,1])
C1517927 (UMLS CUI [2,2])
C1513040 (UMLS CUI [2,3])
C0027627 (UMLS CUI [3,1])
C1513040 (UMLS CUI [3,2])
C0277556 (UMLS CUI [4,1])
C1517927 (UMLS CUI [4,2])
C0027627 (UMLS CUI [5])
Disease HER2 Negative | Disease Hormone Receptor Positive | Disease Estrogen receptor positive | Disease Progesterone receptor positive
Item
human epidermal growth factor receptor 2 (her2)-negative and hr (estrogen receptor and/or progesterone receptor)-positive disease as defined by local guidelines
boolean
C0012634 (UMLS CUI [1,1])
C2348908 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0019929 (UMLS CUI [2,2])
C1514241 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0279754 (UMLS CUI [3,2])
C0012634 (UMLS CUI [4,1])
C0279759 (UMLS CUI [4,2])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0 or 1
boolean
C1520224 (UMLS CUI [1])
Hematologic function | Organ function
Item
adequate hematologic and end organ function
boolean
C0221130 (UMLS CUI [1])
C0678852 (UMLS CUI [2])
Childbearing Potential Sexual Abstinence | Childbearing Potential Contraceptive methods Quantity
Item
women of childbearing potential must agree to remain abstinent or to use two adequate methods of contraception, including at least one method with a failure rate of < 1% per year, during the treatment period and for at least 30 days after the last dose of study treatment or 6 months after discontinuation of paclitaxel, whichever is longer
boolean
C3831118 (UMLS CUI [1,1])
C0036899 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
Prior Chemotherapy Recurrent disease Locally | Prior Chemotherapy Neoplasm Metastasis | Exception Capecitabine
Item
prior non-capecitabine chemotherapy for locally recurrent or metastatic disease
boolean
C1514457 (UMLS CUI [1,1])
C0277556 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C1514457 (UMLS CUI [2,1])
C0027627 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0671970 (UMLS CUI [3,2])
Prior Therapy Advanced breast cancer | Prior Therapy Secondary malignant neoplasm of female breast | PI3K Inhibitor
Item
prior treatment with a pi3k inhibitor for advanced or metastatic breast cancer
boolean
C1514463 (UMLS CUI [1,1])
C3495917 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0346993 (UMLS CUI [2,2])
C1519050 (UMLS CUI [3])
Intolerance to Therapy Containing Taxane
Item
history of intolerance to a taxane-containing therapy
boolean
C1744706 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0332256 (UMLS CUI [1,3])
C0215136 (UMLS CUI [1,4])
Cardiac dysfunction | Pulmonary Dysfunction
Item
history of clinically significant cardiac or pulmonary dysfunction
boolean
C3277906 (UMLS CUI [1])
C1709770 (UMLS CUI [2])
Malabsorption Syndrome | Condition Interferes with Absorption Enteral
Item
history of malabsorption syndrome or other condition that would interfere with enteral absorption
boolean
C0024523 (UMLS CUI [1])
C0348080 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C1304890 (UMLS CUI [2,4])
Liver disease
Item
clinically significant history of liver disease
boolean
C0023895 (UMLS CUI [1])
Autoimmune Disease | Inflammatory disorder
Item
active autoimmune disease or active inflammatory disease
boolean
C0004364 (UMLS CUI [1])
C1290884 (UMLS CUI [2])
Immunocompromised patient
Item
immunocompromised status
boolean
C0085393 (UMLS CUI [1])
Patient need for Steroid therapy chronic
Item
need for current chronic corticosteroid therapy
boolean
C0686904 (UMLS CUI [1,1])
C0149783 (UMLS CUI [1,2])
C0205191 (UMLS CUI [1,3])
Pregnancy | Lactation | Breast Feeding
Item
pregnancy, lactation, or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0022925 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
Systemic disease Severe Uncontrolled
Item
current severe, uncontrolled systemic disease
boolean
C0442893 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
CNS metastases Untreated | CNS metastases
Item
known untreated or active central nervous system (cns) metastases
boolean
C0686377 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2])