Informed Consent
Item
informed consent form signed by the patient to accept study enrollment.
boolean
C0021430 (UMLS CUI [1])
Gender | Invasive carcinoma of breast Operable TNM Breast tumor staging
Item
female with pathologically confirmed diagnosis of primary invasive operable breast cancer, stage iia-iiic (6th edition of the ajcc cancer staging manual), with tumors ≥
boolean
C0079399 (UMLS CUI [1])
C0853879 (UMLS CUI [2,1])
C0205188 (UMLS CUI [2,2])
C0474926 (UMLS CUI [2,3])
Tumor size
Item
2cm.
boolean
C0475440 (UMLS CUI [1])
Triple Negative Breast Neoplasm | Estrogen Receptor Measurement Immunohistochemistry | Progesterone Receptor Measurement Immunohistochemistry | HER2 Immunohistochemistry | HER2 ISH Negative
Item
triple negative phenotype patients (re and pr of less than 1% of stained cells by ihq, ihc for her2 of 0-1+ or ish negative if 2/3+), according to local laboratory.
boolean
C3539878 (UMLS CUI [1])
C3811131 (UMLS CUI [2,1])
C0021044 (UMLS CUI [2,2])
C3889640 (UMLS CUI [3,1])
C0021044 (UMLS CUI [3,2])
C0069515 (UMLS CUI [4,1])
C0021044 (UMLS CUI [4,2])
C0069515 (UMLS CUI [5,1])
C3853647 (UMLS CUI [5,2])
C1513916 (UMLS CUI [5,3])
Age
Item
age 18-75 years.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
adequate performance status (ecog <2).
boolean
C1520224 (UMLS CUI [1])
Renal function | Liver function | Bone Marrow Mature Neutrophils Present
Item
adequate renal and liver function and bone marrow reserve.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C1708947 (UMLS CUI [3,2])
Neoplasm Metastasis
Item
clinical or radiologic evidence of metastatic disease.
boolean
C0027627 (UMLS CUI [1])
Cancer treatment Disease Current | Hormone Therapy | Chemotherapy | Therapeutic radiology procedure | Immunotherapy
Item
prior or concurrent anti-cancer therapy for current disease (hormone therapy, chemotherapy, radiotherapy, immunotherapy).
boolean
C0920425 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,3])
C0279025 (UMLS CUI [2])
C0392920 (UMLS CUI [3])
C1522449 (UMLS CUI [4])
C0021083 (UMLS CUI [5])
Cancer treatment Previous | taxane | Anthracyclines | Carboplatin
Item
prior therapy with taxanes, anthracyclines or carboplatin for any malignancy.
boolean
C0920425 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0215136 (UMLS CUI [2])
C0282564 (UMLS CUI [3])
C0079083 (UMLS CUI [4])
Medical contraindication Investigational New Drugs | Medical contraindication Docetaxel | Medical contraindication Carboplatin
Item
contraindication for study drugs (docetaxel or carboplatin).
boolean
C1301624 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0246415 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C0079083 (UMLS CUI [3,2])
Comorbidity Systemic Serious | Comorbidity compromises Completion of clinical trial | Disease Worsening Due to Chemotherapy | Disease Worsening Due to Adjuvant therapy
Item
serious concomitant systemic disorder that in the opinion of the investigator would compromise the patient's ability to complete the study, or have any other disease that could be worsened by chemotherapy or other potential support therapies.
boolean
C0009488 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C2945640 (UMLS CUI [2,2])
C2732579 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0332271 (UMLS CUI [3,2])
C0678226 (UMLS CUI [3,3])
C0392920 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0332271 (UMLS CUI [4,2])
C0678226 (UMLS CUI [4,3])
C0677850 (UMLS CUI [4,4])