Breast Carcinoma TNM Breast tumor staging | Positive Axillary Lymph Node Absent | Positive Axillary Lymph Node Quantity Sentinel Lymph Node Biopsy | Positive Axillary Lymph Node Quantity Ultrasound guided biopsy | Positive Axillary Lymph Node Quantity Core needle biopsy of breast using palpation guidance | Positive Axillary Lymph Node Quantity Fine needle aspiration
Item
ct1-2 invasive breast cancer, without or with one or more pathologically proven tumour positive axillary lymph nodes (either by sentinel node biopsy, ultrasound/palpation guided biopsy or fine needle aspiration)
boolean
C0678222 (UMLS CUI [1,1])
C0474926 (UMLS CUI [1,2])
C0677929 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0677929 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0796693 (UMLS CUI [3,3])
C0677929 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C0456900 (UMLS CUI [4,3])
C0677929 (UMLS CUI [5,1])
C1265611 (UMLS CUI [5,2])
C2919889 (UMLS CUI [5,3])
C0677929 (UMLS CUI [6,1])
C1265611 (UMLS CUI [6,2])
C1510483 (UMLS CUI [6,3])
Systemic therapy Course Quantity
Item
at least 3 cycles of primary systemic treatment have been given (irrespective of the regimen)
boolean
C1515119 (UMLS CUI [1,1])
C0750729 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Excision of axillary lymph nodes Absent | Status pre- Chemotherapy
Item
no standard axillary lymph node dissection is performed prior to chemotherapy
boolean
C0193867 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0332152 (UMLS CUI [2,1])
C0392920 (UMLS CUI [2,2])
Invasive carcinoma of breast TNM Breast tumor staging | Status pre- Therapeutic procedure
Item
ct3-t4 invasive breast cancer prior to any treatment
boolean
C0853879 (UMLS CUI [1,1])
C0474926 (UMLS CUI [1,2])
C0332152 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
Axillary lymph nodes Suspicious Quantity Imaging
Item
patients with > 3 suspicious axillary nodes on imaging
boolean
C0729594 (UMLS CUI [1,1])
C0750493 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0011923 (UMLS CUI [1,4])
TNM Breast tumor staging | Status pre- Therapeutic procedure
Item
cn2-3 prior to any treatment
boolean
C0474926 (UMLS CUI [1])
C0332152 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
Operative Surgical Procedure Focal | Breast-Conserving Surgery
Item
more than focally irradical surgery and breast conserving therapy
boolean
C0543467 (UMLS CUI [1,1])
C0205234 (UMLS CUI [1,2])
C0917927 (UMLS CUI [2])
Eligibility Clinical Trial Specified | Axilla Ultrasonography | Fine needle aspiration biopsy of axilla using ultrasound guidance | Core needle biopsy of axilla using ultrasound guidance | Lymphadenopathy MRI
Item
to investigate whether a patient is eligible for the rapchem study, a meticulous examination of the axilla is necessary. therefore each patient should undergo an ultrasound of the axilla and if possible an ultrasound guided needle biopsy unb (fna or core). the us/unb can be performed instantly or as second look in case of enlarged nodes on mri. the criteria for performing an unb are:
boolean
C1548635 (UMLS CUI [1,1])
C0008976 (UMLS CUI [1,2])
C0205369 (UMLS CUI [1,3])
C0004454 (UMLS CUI [2,1])
C0041618 (UMLS CUI [2,2])
C2316139 (UMLS CUI [3])
C2316399 (UMLS CUI [4])
C0497156 (UMLS CUI [5,1])
C0024485 (UMLS CUI [5,2])
Cortex of lymph node Length
Item
cortex >2.3 mm not measured at the poles of the node; or
boolean
C0933402 (UMLS CUI [1,1])
C1444754 (UMLS CUI [1,2])
Absence Hilum Fatty
Item
disappearance of the fatty hilum; or
boolean
C0332197 (UMLS CUI [1,1])
C0229703 (UMLS CUI [1,2])
C0001527 (UMLS CUI [1,3])
Cortex of lymph node Bulging Asymmetric
Item
asymmetric bulging of the cortex of a lymph node;
boolean
C0933402 (UMLS CUI [1,1])
C0038999 (UMLS CUI [1,2])
C0332514 (UMLS CUI [1,3])
Axilla TNM clinical staging PET/CT scan | Axilla TNM clinical staging Ultrasonography | Axillary lymph nodes Positive Quantity
Item
if a pet-ct is performed the worst outcome of the two studies is accepted as the real clinical stage of the axilla (i.e. 1 pa proven positive lymph node on ultrasound and 3 on pet-ct; means 3 positive lymph nodes)
boolean
C0004454 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C1699633 (UMLS CUI [1,3])
C0004454 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
C0041618 (UMLS CUI [2,3])
C0729594 (UMLS CUI [3,1])
C1514241 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
Axilla TNM clinical staging | Status pre- Chemotherapy
Item
the n status of the axilla prior to chemotherapy is based upon:
boolean
C0004454 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0332152 (UMLS CUI [2,1])
C0392920 (UMLS CUI [2,2])
Axillary lymph nodes Positive Quantity PET/CT scan
Item
positive pet-ct of more than one but less than 4 axillary nodes; since the specificity of pet positive nodes in a proven breast cancer patient is very high, pathology confirmation is not absolutely required
boolean
C0729594 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1699633 (UMLS CUI [1,4])
Axillary lymph nodes Positive Ultrasonography | Axillary lymph nodes Positive Quantity Pathology
Item
positive us of axillary nodes; at least one should be pathology proven tumour positive
boolean
C0729594 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0041618 (UMLS CUI [1,3])
C0729594 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0919386 (UMLS CUI [2,4])
Axillary lymph nodes TNM clinical staging
Item
the worst outcome of 1 and 2 represents the most reliable clinical axillary staging.
boolean
C0729594 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])