Locally advanced breast cancer unresectable | Secondary malignant neoplasm of female breast
Item
locally advanced/unresectable or metastatic breast cancer
boolean
C3495949 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C0346993 (UMLS CUI [2])
Age
Item
eighteen years of age or above
boolean
C0001779 (UMLS CUI [1])
Informed Consent | Informed Consent Patient Representative
Item
able to understand and sign an informed consent (or have a legal representative who is able to do so)
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0030701 (UMLS CUI [2,2])
Measurable Disease
Item
measurable disease according to recist v1.1
boolean
C1513041 (UMLS CUI [1])
ECOG performance status
Item
ecog performance score of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Bone Marrow function | Liver function | Renal function | Cardiac function
Item
adequate bone marrow, hepatic, renal and cardiac function
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
C0232164 (UMLS CUI [4])
Sexual Abstinence | Contraceptive methods
Item
willing to abstain from sexual intercourse or to use an effective form of contraception during the study and for 90 days following the last dose of mm-302
boolean
C0036899 (UMLS CUI [1])
C0700589 (UMLS CUI [2])
Availability of Cancer treatment Curative
Item
patients for whom potentially curative anticancer therapy is available
boolean
C0470187 (UMLS CUI [1,1])
C0920425 (UMLS CUI [1,2])
C1276305 (UMLS CUI [1,3])
Communicable Disease | Fever
Item
active infection or fever > 38.5°c during screening visits or on the first scheduled day of dosing
boolean
C0009450 (UMLS CUI [1])
C0015967 (UMLS CUI [2])
CNS disorder Symptomatic
Item
symptomatic cns disease
boolean
C0007682 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
Hypersensitivity Component MM-302 | Allergic Reaction Monoclonal Antibodies Human
Item
known hypersensitivity to any of the components of mm-302 or who have had hypersensitivity reactions to fully human monoclonal antibodies
boolean
C0020517 (UMLS CUI [1,1])
C1705248 (UMLS CUI [1,2])
C3272509 (UMLS CUI [1,3])
C1527304 (UMLS CUI [2,1])
C0003250 (UMLS CUI [2,2])
C0086418 (UMLS CUI [2,3])
Cancer treatment Other
Item
received other recent antitumor therapy
boolean
C0920425 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Medical condition Interferes with Informed Consent | Medical condition Interferes with Compliance behavior | Medical condition Interferes with Study Subject Participation Status | Medical condition Interferes with Interpretation Research results | Mental condition Interferes with Informed Consent | Mental condition Interferes with Compliance behavior | Mental condition Interferes with Study Subject Participation Status | Mental condition Interferes with Interpretation Research results
Item
patients with any other medical or psychological condition, deemed by the investigator to be likely to interfere with a patient's ability to sign informed consent, cooperate and participate in the study, or interfere with the interpretation of the results
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1321605 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C3843040 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0459471 (UMLS CUI [4,3])
C0683954 (UMLS CUI [4,4])
C3840291 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0021430 (UMLS CUI [5,3])
C3840291 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C1321605 (UMLS CUI [6,3])
C3840291 (UMLS CUI [7,1])
C0521102 (UMLS CUI [7,2])
C2348568 (UMLS CUI [7,3])
C3840291 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C0459471 (UMLS CUI [8,3])
C0683954 (UMLS CUI [8,4])