Locally advanced breast cancer | Tumor Diameter
Item
women with histology proven locally advanced breast cancer (labc) or tumours >3 cm in diameter.
boolean
C3495949 (UMLS CUI [1])
C0027651 (UMLS CUI [2,1])
C1301886 (UMLS CUI [2,2])
ECOG performance status
Item
ecog performance status 0-1.
boolean
C1520224 (UMLS CUI [1])
Age
Item
age ≥18 years.
boolean
C0001779 (UMLS CUI [1])
Prior Therapy Absent Breast Carcinoma | Neoadjuvant Chemotherapy Scheduled
Item
no prior treatment for breast cancer and scheduled to commence neoadjuvant chemotherapy in <3 weeks time.
boolean
C1514463 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0678222 (UMLS CUI [1,3])
C0600558 (UMLS CUI [2,1])
C3665472 (UMLS CUI [2,2])
C0205539 (UMLS CUI [2,3])
Informed Consent | Protocol Compliance
Item
have given written informed consent and are capable of cooperating with protocol.
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
Bone Marrow function | Renal function | Liver function
Item
adequate bone marrow, renal and liver function.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
Therapeutic radiology procedure | Major surgery | Traumatic injury | Hormone Therapy | Immunotherapy | Chemotherapy | Therapy, Investigational
Item
radiotherapy, major surgery, significant traumatic injury, endocrine therapy, immunotherapy, chemotherapy or experimental therapy during four weeks prior to starting or during trial.
boolean
C1522449 (UMLS CUI [1])
C0679637 (UMLS CUI [2])
C3263723 (UMLS CUI [3])
C0279025 (UMLS CUI [4])
C0021083 (UMLS CUI [5])
C0392920 (UMLS CUI [6])
C0949266 (UMLS CUI [7])
Pregnancy | Breast Feeding
Item
pregnancy or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Non-Insulin-Dependent
Item
history of type 1 or type 2 diabetes.
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
Glucose measurement, serum
Item
serum glucose greater than 7.0 mmol/l.
boolean
C0202041 (UMLS CUI [1])
Metformin
Item
treatment with metformin in the past year.
boolean
C0025598 (UMLS CUI [1])
Estimated Glomerular Filtration Rate
Item
estimated glomerular filtration rate (egfr) <45ml/min.
boolean
C3811844 (UMLS CUI [1])
Metabolic acidosis | Chronic metabolic acidosis
Item
acute or chronic metabolic acidosis
boolean
C0220981 (UMLS CUI [1])
C0740749 (UMLS CUI [2])
Metformin allergy
Item
known hypersensitivity to metformin
boolean
C0571648 (UMLS CUI [1])
Mental condition Study Subject Participation Status Poor | Mental condition Interferes with Protocol Compliance | Mental condition Interferes with Interpretation Research results | Social Condition Study Subject Participation Status Poor | Social Condition Interferes with Protocol Compliance | Social Condition Interferes with Interpretation Research results | Medical condition Study Subject Participation Status Poor | Medical condition Interferes with Protocol Compliance | Medical condition Interferes with Interpretation Research results | Physical Examination Study Subject Participation Status Poor | Physical Examination Interferes with Protocol Compliance | Physical Examination Interferes with Interpretation Research results | Laboratory test result abnormal Study Subject Participation Status Poor | Laboratory test result abnormal Interferes with Protocol Compliance | Laboratory test result abnormal Interferes with Interpretation Research results
Item
other psychological, social or medical condition, physical examination finding or a laboratory abnormality that the investigator considers would make the patient a poor trial candidate or could interfere with protocol compliance or the interpretation of trial results.
boolean
C3840291 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C2700379 (UMLS CUI [1,3])
C3840291 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C3840291 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0459471 (UMLS CUI [3,3])
C0683954 (UMLS CUI [3,4])
C0037403 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C2700379 (UMLS CUI [4,3])
C0037403 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0525058 (UMLS CUI [5,3])
C0037403 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0459471 (UMLS CUI [6,3])
C0683954 (UMLS CUI [6,4])
C3843040 (UMLS CUI [7,1])
C2348568 (UMLS CUI [7,2])
C2700379 (UMLS CUI [7,3])
C3843040 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C0525058 (UMLS CUI [8,3])
C3843040 (UMLS CUI [9,1])
C0521102 (UMLS CUI [9,2])
C0459471 (UMLS CUI [9,3])
C0683954 (UMLS CUI [9,4])
C0031809 (UMLS CUI [10,1])
C2348568 (UMLS CUI [10,2])
C2700379 (UMLS CUI [10,3])
C0031809 (UMLS CUI [11,1])
C0521102 (UMLS CUI [11,2])
C0525058 (UMLS CUI [11,3])
C0031809 (UMLS CUI [12,1])
C0521102 (UMLS CUI [12,2])
C0459471 (UMLS CUI [12,3])
C0683954 (UMLS CUI [12,4])
C0438215 (UMLS CUI [13,1])
C2348568 (UMLS CUI [13,2])
C2700379 (UMLS CUI [13,3])
C0438215 (UMLS CUI [14,1])
C0521102 (UMLS CUI [14,2])
C0525058 (UMLS CUI [14,3])
C0438215 (UMLS CUI [15,1])
C0521102 (UMLS CUI [15,2])
C0459471 (UMLS CUI [15,3])
C0683954 (UMLS CUI [15,4])