Neoplasm Metastasis TNM Breast tumor staging | Recurrent disease Locally TNM Breast tumor staging | Excision Curative Unsuccessful | Therapeutic radiology procedure Unsuccessful
Item
histologically or cytologically confirmed diagnosis with evidence of either metastatic disease (stage iv) of locally recurrent disease not amenable to curative resection or radiation therapy (stage iiib).
boolean
C0027627 (UMLS CUI [1,1])
C0474926 (UMLS CUI [1,2])
C0277556 (UMLS CUI [2,1])
C1517927 (UMLS CUI [2,2])
C0474926 (UMLS CUI [2,3])
C0728940 (UMLS CUI [3,1])
C1276305 (UMLS CUI [3,2])
C1272705 (UMLS CUI [3,3])
C1522449 (UMLS CUI [4,1])
C1272705 (UMLS CUI [4,2])
Breast Carcinoma HER2 Negative | HER2 Status Unknown
Item
her-2negative breast cancer or unknown her-2 status.
boolean
C0678222 (UMLS CUI [1,1])
C2348908 (UMLS CUI [1,2])
C2348910 (UMLS CUI [2])
Measurable Disease Quantity
Item
at least 1 measurable lesion as defined by recist.
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
ECOG performance status
Item
ecog status 0-1
boolean
C1520224 (UMLS CUI [1])
Bone Marrow function | Liver function | Renal function
Item
adequate bone marrow, hepatic and renal function.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Left ventricular ejection fraction
Item
left ventricular ejection fraction of greater than or equal to 50%.
boolean
C0428772 (UMLS CUI [1])
Hormone Therapy Discontinue Willing
Item
willingness to discontinue hormonal therapy.
boolean
C0279025 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C0600109 (UMLS CUI [1,3])
Prior Chemotherapy Advanced disease
Item
any previous chemotherapy for advanced disease.
boolean
C1514457 (UMLS CUI [1,1])
C0679246 (UMLS CUI [1,2])
Exposure to Taxanes Adjuvant therapy | Exposure to Taxanes Neoadjuvant Therapy
Item
prior exposure to taxanes as (neo) adjuvant treatment less than 12 months prior to randomization.
boolean
C0332157 (UMLS CUI [1,1])
C0796419 (UMLS CUI [1,2])
C0677850 (UMLS CUI [1,3])
C0332157 (UMLS CUI [2,1])
C0796419 (UMLS CUI [2,2])
C0600558 (UMLS CUI [2,3])
Metastatic malignant neoplasm to brain Symptomatic
Item
symptomatic brain metastases.
boolean
C0220650 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
IGF1R inhibitors Investigational Therapy
Item
prior anti-igf-1r based investigational therapy.
boolean
C4044495 (UMLS CUI [1,1])
C0243077 (UMLS CUI [1,2])
C0949266 (UMLS CUI [1,3])
Peripheral Neuropathy CTCAE Grades
Item
peripheral neuropathy greater than grade 2.
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])