B-cell Malignancies | Burkitt Lymphoma | Childhood Burkitt Leukemia FAB Classification | Diffuse Large B-Cell Lymphoma | Mature B-Cell Non-Hodgkin Lymphoma
Item
histologically or cytologically proven b-cell malignancies, either burkitt lymphoma or b-al (=burkitt leukaemia = l3-al) or diffuse large b-cell nhl or aggressive mature b-cell nhl non other specified or specifiable.
boolean
C0004561 (UMLS CUI [1,1])
C0006826 (UMLS CUI [1,2])
C0006413 (UMLS CUI [2])
C0279582 (UMLS CUI [3,1])
C2984084 (UMLS CUI [3,2])
C0079744 (UMLS CUI [4])
C1334634 (UMLS CUI [5])
Ann Arbor lymphoma staging system | Serum LDH level elevated | Childhood Burkitt Leukemia
Item
stage iii with elevated ldh level ("b-high"), [ldh > twice the institutional upper limit of the adult normal values (> nx2)] or any stage iv or b-al.
boolean
C0432516 (UMLS CUI [1])
C1275604 (UMLS CUI [2])
C0279582 (UMLS CUI [3])
Age
Item
6 months to less than 18 years of age at the time of consent.
boolean
C0001779 (UMLS CUI [1])
Females & males of reproductive potential Contraceptive methods | Relationship Characteristics Rituximab | Relationship Characteristics Methotrexate
Item
males and females of reproductive potential must agree to use an effective contraceptive method during the treatment, and after the end of treatment: during twelve months for women, taking into account the characteristics of rituximab and during five months for men, taking into account the characteristics of methotrexate.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0439849 (UMLS CUI [2,1])
C1521970 (UMLS CUI [2,2])
C0393022 (UMLS CUI [2,3])
C0439849 (UMLS CUI [3,1])
C1521970 (UMLS CUI [3,2])
C0025677 (UMLS CUI [3,3])
Work up Initial Complete
Item
complete initial work-up within 8 days prior to treatment that allows definite staging.
boolean
C0750430 (UMLS CUI [1,1])
C0205265 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
Compliance Follow-up Scheduled | Compliance Management Toxicity
Item
able to comply with scheduled follow-up and with management of toxicity.
boolean
C1321605 (UMLS CUI [1,1])
C3274571 (UMLS CUI [1,2])
C0205539 (UMLS CUI [1,3])
C1321605 (UMLS CUI [2,1])
C1273870 (UMLS CUI [2,2])
C0600688 (UMLS CUI [2,3])
Informed Consent | Informed Consent Parent | Informed Consent Guardian
Item
signed informed consent from patients and/or their parents or legal guardians
boolean
C0021430 (UMLS CUI [1])
C0021430 (UMLS CUI [2,1])
C0030551 (UMLS CUI [2,2])
C0021430 (UMLS CUI [3,1])
C1274041 (UMLS CUI [3,2])
Lymphoma, Follicular | MALT Lymphoma | Nodal marginal zone lymphoma
Item
follicular lymphoma, malt and nodular marginal zone are not included into this therapeutic study
boolean
C0024301 (UMLS CUI [1])
C0242647 (UMLS CUI [2])
C0855139 (UMLS CUI [3])
Immunodeficiency congenital | Nijmegen Breakage Syndrome | Organ Transplantation Previous | Malignant Neoplasms Previous | HIV Seropositivity
Item
patients with congenital immunodeficiency, chromosomal breakage syndrome, prior organ transplantation, previous malignancy of any type, or known positive hiv serology.
boolean
C0853602 (UMLS CUI [1])
C0398791 (UMLS CUI [2])
C0029216 (UMLS CUI [3,1])
C0205156 (UMLS CUI [3,2])
C0006826 (UMLS CUI [4,1])
C0205156 (UMLS CUI [4,2])
C0019699 (UMLS CUI [5])
Pregnancy | Breast Feeding
Item
evidence of pregnancy or lactation period.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Exclusion Criteria Absent Organ function
Item
there will be no exclusion criteria based on organ function.
boolean
C0680251 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0678852 (UMLS CUI [1,3])
Cancer treatment | Exception Adrenal Cortex Hormones
Item
past or current anti-cancer treatment except corticosteroids during less than one week.
boolean
C0920425 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0001617 (UMLS CUI [2,2])
Neoplastic Cell CD20 Negative
Item
tumor cell negative for cd20
boolean
C0597032 (UMLS CUI [1,1])
C4527200 (UMLS CUI [1,2])
Exposure to Rituximab
Item
prior exposure to rituximab.
boolean
C0332157 (UMLS CUI [1,1])
C0393022 (UMLS CUI [1,2])
Virus Disease Severe | Hepatitis B
Item
severe active viral infection, especially hepatitis b.
boolean
C0042769 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0019163 (UMLS CUI [2])
Hepatitis B carrier | Hepatitis B | HEPATITIS B SEROLOGY POSITIVE
Item
hepatitis b carrier status history of hbv or positive serology.
boolean
C0262505 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0744838 (UMLS CUI [3])
Study Subject Participation Status | Investigational New Drugs
Item
participation in another investigational drug clinical trial.
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
Compliance Unable Legislation
Item
patients who, for any reason, are not able to comply with the national legislation.
boolean
C1321605 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0023252 (UMLS CUI [1,3])