Age
Item
greater than or equal to 18 years of age;
boolean
C0001779 (UMLS CUI [1])
Atrial Fibrillation
Item
confirmed diagnosis of non valvular atrial fibrillation (nvaf) (diagnosis of af is considered confirmed if there is medical chart documentation that the patient has atrial fibrillation or af or the icd-9 or icd-10 code for af is documented);
boolean
C0004238 (UMLS CUI [1])
Atrial Fibrillation | Cardiac Arrhythmia | Rheumatic mitral stenosis Absent | Heart Valve Prosthesis Absent
Item
nvaf is defined as follows: nonvalvular atrial fibrillation is restricted to cases in which the rhythm disturbance occurs in the absence of rheumatic mitral stenosis or a prosthetic heart valve.
boolean
C0004238 (UMLS CUI [1])
C0003811 (UMLS CUI [2])
C0264766 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0018825 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
Hemorrhage Event Major | Clinic Visit Emergency department
Item
documentation that the patient presented to an emergency department/emergency room (ed/er) for a major bleeding event (index event);
boolean
C0019080 (UMLS CUI [1,1])
C0441471 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0008952 (UMLS CUI [2,1])
C0562508 (UMLS CUI [2,2])
Hemorrhage Major Definition
Item
major bleeding is defined by international society on thrombosis and haemostasis (isth) as:
boolean
C0019080 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C1704788 (UMLS CUI [1,3])
Hemorrhage Fatal
Item
fatal bleeding and/or
boolean
C0019080 (UMLS CUI [1,1])
C1302234 (UMLS CUI [1,2])
Symptomatic bleeding Area Critical | Area Intracranial | Area Intraspinal | Area Intraocular | Retroperitoneal Space | Area Intra-articular | Area Pericardial | Area Intramuscular | Compartment syndromes
Item
symptomatic bleeding in a critical area/organ such as intracranial, intraspinal, intraocular, retroperitoneal, intra-articular or pericardial, or intramuscular with compartment syndrome, and/or
boolean
C4324376 (UMLS CUI [1,1])
C0205146 (UMLS CUI [1,2])
C1511545 (UMLS CUI [1,3])
C0205146 (UMLS CUI [2,1])
C0524466 (UMLS CUI [2,2])
C0205146 (UMLS CUI [3,1])
C1283188 (UMLS CUI [3,2])
C0205146 (UMLS CUI [4,1])
C3282905 (UMLS CUI [4,2])
C0035359 (UMLS CUI [5])
C0205146 (UMLS CUI [6,1])
C0442108 (UMLS CUI [6,2])
C0205146 (UMLS CUI [7,1])
C0031050 (UMLS CUI [7,2])
C0205146 (UMLS CUI [8,1])
C0442117 (UMLS CUI [8,2])
C0009492 (UMLS CUI [9])
Hemorrhage Causing Hemoglobin drop | Hemorrhage Causing Transfusion whole blood (___ units) | Hemorrhage Causing Red Blood Cell Transfusion
Item
bleeding causing a fall in hemoglobin of 20g per liter or more, or leading to transfusion of 2 or more units of whole blood or red blood cells
boolean
C0019080 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C0162119 (UMLS CUI [1,3])
C0019080 (UMLS CUI [2,1])
C0678227 (UMLS CUI [2,2])
C3645956 (UMLS CUI [2,3])
C0019080 (UMLS CUI [3,1])
C0678227 (UMLS CUI [3,2])
C0086252 (UMLS CUI [3,3])
Event Occurrence | Dabigatran Dose Quantity
Item
documentation that the index event occurred in a patient who reported having taken at least one dose of dabigatran within the 5 days prior to the index event.
boolean
C0441471 (UMLS CUI [1,1])
C2745955 (UMLS CUI [1,2])
C2348066 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
Atrial Fibrillation Involvement with Valve
Item
confirmed diagnosis of valvular af (diagnosis of valvular af is considered confirmed if there is medical chart documentation that the patient has valvular af or vaf. in the absence of documentation to indicate whether the patient has non-valvular or valvular af,);
boolean
C0004238 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C1186983 (UMLS CUI [1,3])
Dabigatran with Anticoagulants | Anticoagulants Parenteral | Oral anticoagulants
Item
documentation that the patient was taking dabigatran with a concomitant anticoagulant (contemporaneous parenteral anticoagulant or another oral anticoagulant) within 72 hours of the index event;
boolean
C2348066 (UMLS CUI [1,1])
C0332287 (UMLS CUI [1,2])
C0003280 (UMLS CUI [1,3])
C0003280 (UMLS CUI [2,1])
C1518896 (UMLS CUI [2,2])
C0354604 (UMLS CUI [3])
Antiplatelet Agents Previous allowed
Item
the concomitant administration of antiplatelet medications prior to the onset of the index event is not exclusionary;
boolean
C0085826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0683607 (UMLS CUI [1,3])
Thrombolytic Therapy
Item
documentation of the patient receiving thrombolytic therapy within 48 hours of the onset of the index event;
boolean
C0040044 (UMLS CUI [1])
Study Subject Participation Status | Interventional Study | Observational Study
Item
documentation that the patient was enrolled in an interventional investigational or other bi observational clinical trial at the time of the onset of the index event;
boolean
C2348568 (UMLS CUI [1])
C3274035 (UMLS CUI [2])
C1518527 (UMLS CUI [3])
Medical record not available | Medical record lost | Medical Record Empty
Item
medical record was not retrievable, was missing or empty.
boolean
C1320768 (UMLS CUI [1])
C0746463 (UMLS CUI [2])
C0025102 (UMLS CUI [3,1])
C1880497 (UMLS CUI [3,2])