Epithelial Ovarian Cancer, FIGO stage
Item
Primary diagnosis of histologically-confirmed epithelial carcinoma FIGO stage IC - IV, regardless of measurable or non-measurable disease.
boolean
C0677886 (UMLS CUI [1,1])
C0450454 (UMLS CUI [1,2])
Prior Chemotherapy; prior radiation therapy
Item
No prior chemo- or radiotherapy
boolean
C1514457 (UMLS CUI [1])
C0279134 (UMLS CUI [2])
Age
Item
At least 18 years of age.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status, Karnofsky Performance status
Item
Performance status 0-2 (ECOG scale) or >60 (Karnofsky).
boolean
C1520224 (UMLS CUI [1,1])
C0206065 (UMLS CUI [1,2])
Life Expectancy
Item
Life expectancy greater than 12 weeks.
boolean
C0023671 (UMLS CUI [1])
Residual Tumor
Item
Residual tumor < 1.0 cm (optimally debulked).
boolean
C0543478 (UMLS CUI [1])
Hemotologic function; Renal function; Liver function
Item
Adequate hematologic, renal and hepatic function defined as follows: WBC > 3.5 x 10^9/l ANC > 1.5 x 10^9/l Platelet count > 100 x 10^9/l Hemoglobin > 9 g/dl (after transfusion, if needed) Total bilirubin < 1.5 x ULN Alkaline phosphatase < 3 x ULN Estimated GFR > 60 ml/min or Serum creatinine < 150 μmol/l
boolean
C0221130 (UMLS CUI [1,1])
C0232804 (UMLS CUI [1,2])
C0232741 (UMLS CUI [1,3])
Informed Consent
Item
Patient consent must be obtained according to the local ethics comittee requirements. Patients must be alert and able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Epithelioma; Mucinous cystic tumor of borderline malignancy
Item
Non-epithelial tumors or mixed epithelial/non-epithelial tumors or tumors of low malignant potential (borderline tumors).
boolean
C1368683 (UMLS CUI [1])
C0334365 (UMLS CUI [2])
Prior Chemotherapy; prior radiation therapy
Item
Prior treatment with chemo- or radiotherapy.
boolean
C1514457 (UMLS CUI [1,1])
C0279134 (UMLS CUI [1,2])
Residual Tumor
Item
Residual tumor after surgery > 1 cm.
boolean
C0543478 (UMLS CUI [1])
Communicable Disease; Disease
Item
Active infection or other serious underlying medical condition, which would impair the ability of the patient to be treated according to protocol.
boolean
C000945 (UMLS CUI [1])
C0012634 (UMLS CUI [2])
Dementia; Abnormal mental state
Item
Dementia or significantly altered mental status that would prohibit understanding and giving informed consent.
boolean
C0497327 (UMLS CUI [1])
C0278061 (UMLS CUI [2])
Experimental drug, Hypersensitivity
Item
History of allergic reactions to compounds chemically related to carboplatin or topotecan.
boolean
C0304229 (UMLS CUI [1,1])
C0020517 (UMLS CUI [1,2])
Other medical condition,at risk; Therapeutic procedure, at risk
Item
Any other condition or therapy that, in the investigator's opinion, may pose a risk to the patient or interfere with the study objectives?
boolean
C3843040 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
Malignant Neoplasms
Item
Past or current history of malignancy other than the entry diagnosis, except curatively treated non-melanoma skin cancer or carcinoma in situ of the cervix.
boolean
C0006826 (UMLS CUI [1])
Chemotherapy, Simultaneous; Hormone therapy, Simultaneous; Therapeutic radiology procedure, Simultaneous
Item
Administration of other simultaineous chemotherapeutic drugs or hormonal therapy or simultaneous radiotherapy during the study treatment period or planned whole abdominal radiotherapy.
boolean
C3665472 (UMLS CUI [1,1])
C0521115 (UMLS CUI [1,2])
C0279025 (UMLS CUI [2,1])
C0521115 (UMLS CUI [2,2])
C1522449 (UMLS CUI [3,1])
C0521115 (UMLS CUI [3,2])