Adult | Age | Coronary Artery Bypass Surgery Standard | Surgical Procedures on the Aortic Valve
Item
all consecutive adult patients (age > 40) undergoing standard (non-minimally invasive) coronary artery bypass surgery and/or aortic valve surgery will be approached for enrollment.
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0010055 (UMLS CUI [3,1])
C1442989 (UMLS CUI [3,2])
C0519381 (UMLS CUI [4])
Informed Consent | Compliance Follow-up
Item
all patients must be able to provide informed consent and comply with the 3 month follow-up.
boolean
C0021430 (UMLS CUI [1])
C1321605 (UMLS CUI [2,1])
C3274571 (UMLS CUI [2,2])
Childbearing Potential Contraceptive methods
Item
for women of reproductive capability, contraception is necessary and required.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Exclusion Criteria Fulfill Baseline
Item
all candidates meeting any of the exclusion criteria at baseline will be excluded from study participation:
boolean
C0680251 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])
Estimated Glomerular Filtration Rate | Creatinine measurement, serum | Requirement Dialysis
Item
egfr < 30 ml/min/1.73 m2, serum creatinine > 2.5 mg/dl or requiring dialysis
boolean
C3811844 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C1514873 (UMLS CUI [3,1])
C0011946 (UMLS CUI [3,2])
Permanent atrial fibrillation | Atrial Fibrillation
Item
known permanent or current atrial fibrillation (history of paroxysmal atrial fibrillation allowed if in sinus rhythm at present)
boolean
C2586056 (UMLS CUI [1])
C0004238 (UMLS CUI [2])
Colchicine allergy | Colchicine Therapy Pre-existing
Item
allergy to colchicine or already treated with colchicine.
boolean
C0571131 (UMLS CUI [1])
C0009262 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C2347662 (UMLS CUI [2,3])
Hematological Disease | Leukemia | Chronic leukemia | Pancytopenia | Aplastic Anemia | Leukopenia
Item
known blood dyscrasia (acute or chronic leukemia, pancytopenia, aplastic anemia, leukopenia)
boolean
C0018939 (UMLS CUI [1])
C0023418 (UMLS CUI [2])
C1279296 (UMLS CUI [3])
C0030312 (UMLS CUI [4])
C0002874 (UMLS CUI [5])
C0023530 (UMLS CUI [6])
Gastrointestinal Disease Serious
Item
known serious gastrointestinal disease
boolean
C0017178 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Liver disease Severe | Liver Cirrhosis | Aspartate aminotransferase increased | Alanine aminotransferase increased | MELD score
Item
known severe liver disease (cirrhosis, ast/alt > 2x the upper limit of normal, meld score > 20)
boolean
C0023895 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0023890 (UMLS CUI [2])
C0151904 (UMLS CUI [3])
C0151905 (UMLS CUI [4])
C1718072 (UMLS CUI [5])
Childbearing Potential Contraceptive methods Absent
Item
women of childbearing potential not using contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
HIV Infection | AIDS | Protease Inhibitors Resulting in Poisoning by colchicine
Item
patients with hiv or aids as the use of protease inhibitors can result in serious colchicine toxicity.
boolean
C0019693 (UMLS CUI [1])
C0001175 (UMLS CUI [2])
C0033607 (UMLS CUI [3,1])
C0332294 (UMLS CUI [3,2])
C0274779 (UMLS CUI [3,3])
CYP3A4 Inhibitors Strong | Clarithromycin | Erythromycin | Chloramphenicol | Ketoconazole | Itraconazole | nefazodone
Item
patients who are treated with strong cyp3a4 inhibitors (clarithromycin/erythyromycin, chloramphenicol, ketoconazole/itraconazole, and nefazodone).
boolean
C3850053 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C0055856 (UMLS CUI [2])
C0014806 (UMLS CUI [3])
C0008168 (UMLS CUI [4])
C0022625 (UMLS CUI [5])
C0064113 (UMLS CUI [6])
C0068485 (UMLS CUI [7])
Risk Rhabdomyolysis | Digoxin
Item
there is a risk of rhabdomyolysis with the use of digoxin and colchicine, we will exclude patients who require ongoing treatment with digoxin.
boolean
C0035647 (UMLS CUI [1,1])
C0035410 (UMLS CUI [1,2])
C0012265 (UMLS CUI [2])
Informed Consent Unable | Informed Consent Unwilling
Item
inability or unwillingness of the individual to give written informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])