Paroxysmal atrial fibrillation | Persistent atrial fibrillation | Permanent atrial fibrillation
Item
have a documented medical history of paroxysmal, persistent, or permanent non-valvular atrial fibrillation (af)
boolean
C0235480 (UMLS CUI [1])
C2585653 (UMLS CUI [2])
C2586056 (UMLS CUI [3])
Percutaneous Coronary Intervention Atherosclerosis | Placement of stent
Item
have undergone percutaneous coronary intervention (pci) procedure (with stent placement) for primary atherosclerotic disease
boolean
C1532338 (UMLS CUI [1,1])
C0004153 (UMLS CUI [1,2])
C0522776 (UMLS CUI [2])
International Normalized Ratio
Item
must have an international normalized ratio (inr) of 2.5 or below to be randomized
boolean
C0525032 (UMLS CUI [1])
Postmenopausal state | Gender Sexually active Contraceptive methods
Item
women must be postmenopausal before entry or practicing a highly effective method of birth control when heterosexually active
boolean
C0232970 (UMLS CUI [1])
C0079399 (UMLS CUI [2,1])
C0241028 (UMLS CUI [2,2])
C0700589 (UMLS CUI [2,3])
Protocol Compliance
Item
be willing and able to adhere to the prohibitions and restrictions specified in the study protocol
boolean
C0525058 (UMLS CUI [1])
Condition Contraindicated Anticoagulant therapy | Condition Contraindicated Antiplatelet therapy | Bleeding risk Unacceptable | Platelet Count measurement | Intracranial Hemorrhage | Gastrointestinal Hemorrhage Disease length | Elevated prothrombin time Independent of Vitamin K Antagonist
Item
have any condition that contraindicates anticoagulant or antiplatelet therapy or would have an unacceptable risk of bleeding, such as, but not limited to: platelet count <90,000/microliter at screening, history of intracranial hemorrhage, 12 month history of clinically significant gastrointestinal bleeding, non-vka induced elevated prothrombin time (pt) at screening
boolean
C0348080 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0150457 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C1444657 (UMLS CUI [2,2])
C1096021 (UMLS CUI [2,3])
C3251812 (UMLS CUI [3,1])
C1883420 (UMLS CUI [3,2])
C0032181 (UMLS CUI [4])
C0151699 (UMLS CUI [5])
C0017181 (UMLS CUI [6,1])
C0872146 (UMLS CUI [6,2])
C2674387 (UMLS CUI [7,1])
C0332291 (UMLS CUI [7,2])
C2267235 (UMLS CUI [7,3])
Anemia Cause Unknown | Hemoglobin measurement
Item
have anemia of unknown cause with a hemoglobin level <10 g/dl (<6.21 mmol/l)
boolean
C0002871 (UMLS CUI [1,1])
C0015127 (UMLS CUI [1,2])
C0439673 (UMLS CUI [1,3])
C0518015 (UMLS CUI [2])
Cerebrovascular accident | Transient Ischemic Attack
Item
have a history of stroke or transient ischemic attack (tia)
boolean
C0038454 (UMLS CUI [1])
C0007787 (UMLS CUI [2])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
have a calculated creatinine clearance (crcl) <30 ml/min at screening
boolean
C2711451 (UMLS CUI [1])
Liver disease | Liver function tests abnormal
Item
have known significant liver disease or liver function test (lft) abnormalities
boolean
C0023895 (UMLS CUI [1])
C0151766 (UMLS CUI [2])
Condition Severe Limiting Life Expectancy
Item
have any severe condition that would limit life expectancy to less than 12 months
boolean
C0348080 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C0023671 (UMLS CUI [1,4])