Exclusion Criteria
History of relapsing remitting multiple sclerosis, secondary progressive, or progressive relapsing multiple sclerosis at screening
boolean
Contraindications for Magnetic Resonance Imaging (MRI)
boolean
Known presence of other neurologic disorders
boolean
Known active infection or history of or presence of recurrent or chronic infection
boolean
History of cancer, including solid tumors and hematological malignancies (except for basal cell, in situ squamous cell carcinomas of the skin and in situ carcinoma of the cervix that have been excised and resolved)
boolean
Previous treatment with B-cell targeted therapies (e.g. rituximab, ocrelizumab, atacicept, belimumab, or ofatumumab)
boolean
Any previous treatment with lymphocyte trafficking blockers, with alemtuzumab, anti-CD4, cladribine, cyclophosphamide, mitoxantrone, azathioprine, mycophenolate mofetil, cyclosporine, methotrexate, total body irradiation, or bone marrow transplantation
boolean
Any concomitant disease that may require chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study
boolean