Liver carcinoma | Liver carcinoma Imaging finding | Ultrasonography compatible with Liver carcinoma | CT compatible with Liver carcinoma | MRI compatible with Liver carcinoma | Gastrointestinal Neoplasms Other Absent
Item
1. diagnosis of hcc confirmed clinically or histologically or cytologically. a clinical diagnosis of hcc, using the 2010 guideline of the american association for the study of liver diseases requires the presence of hepatic tumor(s) with image findings (e.g. sonography, ct or mri) compatible with hcc, and no evidence of other gastrointestinal tumors (bruix [2011] - guideline, 2010).
boolean
C2239176 (UMLS CUI [1])
C2239176 (UMLS CUI [2,1])
C1287399 (UMLS CUI [2,2])
C0041618 (UMLS CUI [3,1])
C0332290 (UMLS CUI [3,2])
C2239176 (UMLS CUI [3,3])
C0040405 (UMLS CUI [4,1])
C0332290 (UMLS CUI [4,2])
C2239176 (UMLS CUI [4,3])
C0024485 (UMLS CUI [5,1])
C0332290 (UMLS CUI [5,2])
C2239176 (UMLS CUI [5,3])
C0017185 (UMLS CUI [6,1])
C0205394 (UMLS CUI [6,2])
C0332197 (UMLS CUI [6,3])
Liver carcinoma Solitary Diameter CT scan | Disease Multifocal CT scan | Liver carcinoma Solitary Diameter MRI scan | Disease Multifocal MRI scan | Tumor Volume Percentage Excluded | Liver carcinoma Infiltrating Excluded
Item
2. solitary hepatic tumor <8 cm in diameter or multifocal disease as evidenced by ct or mri scan. tumor volume ≥50% of liver organ or infiltrating hcc should be excluded.
boolean
C2239176 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C1301886 (UMLS CUI [1,3])
C0040405 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0205292 (UMLS CUI [2,2])
C0040405 (UMLS CUI [2,3])
C2239176 (UMLS CUI [3,1])
C0205171 (UMLS CUI [3,2])
C1301886 (UMLS CUI [3,3])
C0024485 (UMLS CUI [3,4])
C0012634 (UMLS CUI [4,1])
C0205292 (UMLS CUI [4,2])
C0024485 (UMLS CUI [4,3])
C0475276 (UMLS CUI [5,1])
C0439165 (UMLS CUI [5,2])
C0332196 (UMLS CUI [5,3])
C2239176 (UMLS CUI [6,1])
C0332448 (UMLS CUI [6,2])
C0332196 (UMLS CUI [6,3])
Patient Inappropriate Surgical resection | Patient InappropriateTumor Ablation
Item
3. not a candidate for surgical resection or ablation of the tumor.
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0728940 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C0027651 (UMLS CUI [2,3])
C0547070 (UMLS CUI [2,4])
Local Therapy Absent Target Lesion | Transarterial Chemoembolization Absent | Local Therapy Non-Target Lesion Acceptable | Radiofrequency ablation Non-Target Lesion Acceptable | Percutaneous ethanol injection therapy Non-Target Lesion Acceptable | Cryoablation Non-Target Lesion Acceptable | Operative Surgical Procedure Non-Target Lesion Acceptable
Item
4. the target lesion must not have been treated previously with local therapy, including tace. prior local therapy (radiofrequency ablation, percutaneous ethanol injection, cryoablation, or surgery) to nontarget lesions is acceptable.
boolean
C1517925 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C2986546 (UMLS CUI [1,3])
C3539919 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1517925 (UMLS CUI [3,1])
C2986547 (UMLS CUI [3,2])
C1879533 (UMLS CUI [3,3])
C0850292 (UMLS CUI [4,1])
C2986547 (UMLS CUI [4,2])
C1879533 (UMLS CUI [4,3])
C1535909 (UMLS CUI [5,1])
C2986547 (UMLS CUI [5,2])
C1879533 (UMLS CUI [5,3])
C0010408 (UMLS CUI [6,1])
C2986547 (UMLS CUI [6,2])
C1879533 (UMLS CUI [6,3])
C0543467 (UMLS CUI [7,1])
C2986547 (UMLS CUI [7,2])
C1879533 (UMLS CUI [7,3])
Transarterial Chemoembolization Quantity | Transarterial Chemoembolization Previous
Item
5. the subject must have received no more than 2 tace (n≤ 2) or the previous tace was performed longer than 2 months before enrollment.
boolean
C3539919 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C3539919 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
Local Therapy Completed
Item
6. local therapy must have been completed at least 4 weeks before baseline scan.
boolean
C1517925 (UMLS CUI [1,1])
C0205197 (UMLS CUI [1,2])
Measurable Disease | Measurable lesion Quantity
Item
7. measurable disease using mrecist criteria (appendix a) and recist1.1 (appendix b) criteria. at least 1 measurable lesion must be present.
boolean
C1513041 (UMLS CUI [1])
C1513041 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Hepatocellular Carcinoma by BCLC Stage
Item
8. barcelona clinic liver cancer (bclc) staging classification b (intermediate stage) (appendix c).
boolean
C3898888 (UMLS CUI [1])
Patient Appropriate Curative treatment | Patient Appropriate Excision | Patient Appropriate Transplantation
Item
1. 1. candidate for potential curative therapies (i.e., resection or transplantation).
boolean
C0030705 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C1273390 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C1548787 (UMLS CUI [2,2])
C0728940 (UMLS CUI [2,3])
C0030705 (UMLS CUI [3,1])
C1548787 (UMLS CUI [3,2])
C0040732 (UMLS CUI [3,3])
Transplantation, Homologous | Transplantation of liver
Item
2. prior allograft transplantation including liver transplantation.
boolean
C0040739 (UMLS CUI [1])
C0023911 (UMLS CUI [2])
Heart Disease New York Heart Association Classification
Item
3. significant cardiac disease (new york heart association class iii or iv; appendix f).
boolean
C0018799 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Communicable Disease Serious | Requirement Antibiotics for systemic use
Item
4. serious infection requiring treatment with systemically administered antibiotics.
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C3540704 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
5. pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Compliance behavior Unlikely
Item
6. expected non-compliance.
boolean
C1321605 (UMLS CUI [1,1])
C0750558 (UMLS CUI [1,2])
Comorbidity Uncontrolled | Communicable Disease | Symptomatic congestive heart failure New York Heart Association Classification | Angina, Unstable | Cardiac Arrhythmia | Mental disorder Limiting Protocol Compliance | Social situation Limiting Protocol Compliance
Item
7. uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (new york heart association class iii or iv), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness or social situations that would limit compliance with study requirements.
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2])
C0742758 (UMLS CUI [3,1])
C1275491 (UMLS CUI [3,2])
C0002965 (UMLS CUI [4])
C0003811 (UMLS CUI [5])
C0004936 (UMLS CUI [6,1])
C0439801 (UMLS CUI [6,2])
C0525058 (UMLS CUI [6,3])
C0748872 (UMLS CUI [7,1])
C0439801 (UMLS CUI [7,2])
C0525058 (UMLS CUI [7,3])
Cancer treatment
Item
8. subjects who have had any anticancer treatment within 2 weeks prior to week 1 visit.
boolean
C0920425 (UMLS CUI [1])