Advanced Malignant Solid Neoplasm | Lymphoma Advanced | Life prolongation Standard of Care Unavailable
Item
subjects with histologically or cytologically confirmed advanced solid tumors or lymphoma and for whom standard life-prolonging measures are not available.
boolean
C4329281 (UMLS CUI [1])
C0024299 (UMLS CUI [2,1])
C0205179 (UMLS CUI [2,2])
C0023677 (UMLS CUI [3,1])
C2936643 (UMLS CUI [3,2])
C0686905 (UMLS CUI [3,3])
ECOG performance status
Item
eastern cooperative oncology group: 0 to 2
boolean
C1520224 (UMLS CUI [1])
Hypersensitivity ASTX660 | Hypersensitivity ASTX660 Excipient | Hypersensitivity Investigational Therapy Component
Item
hypersensitivity to astx660, excipients of the drug product, or other components of the study treatment regimen
boolean
C0020517 (UMLS CUI [1,1])
C4086975 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C4086975 (UMLS CUI [2,2])
C0015237 (UMLS CUI [2,3])
C0020517 (UMLS CUI [3,1])
C0949266 (UMLS CUI [3,2])
C1705248 (UMLS CUI [3,3])
Disease Uncontrolled | Communicable Disease Uncontrolled
Item
uncontrolled medical disease(s) or active, uncontrolled infections
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Life threatening illness | Organ system Dysfunction
Item
life-threatening illness or significant organ system dysfunction
boolean
C3846017 (UMLS CUI [1])
C0460002 (UMLS CUI [2,1])
C3887504 (UMLS CUI [2,2])
Heart Disease | At risk Heart Disease
Item
a history of, or at risk for, cardiac disease
boolean
C0018799 (UMLS CUI [1])
C1444641 (UMLS CUI [2,1])
C0018799 (UMLS CUI [2,2])
HIV Infection | Hepatitis B | Hepatitis C
Item
known history of hiv, or hepatitis b (hbv) or c (hcv)
boolean
C0019693 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Neuropathy CTCAE Grades
Item
grade 2 or greater neuropathy
boolean
C0442874 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain | Exception Stable status | Exception Metastatic malignant neoplasm to brain Treated
Item
known brain metastases unless stable or previously treated
boolean
C0220650 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0220650 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
Mental disorder
Item
known significant mental illness
boolean
C0004936 (UMLS CUI [1])
Cancer treatment Previous
Item
prior anticancer treatments or therapies within specified time windows prior to first dose of study treatment (astx660)
boolean
C0920425 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or nursing an infant
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])