Age
Item
male or female, aged 18-65 years.
boolean
C0001779 (UMLS CUI [1])
Asthma | Inhalation beta2-Adrenergic Agonist Short-term Active | Inhaled steroids Low dose
Item
asthma treated by inhaled saba or inhaled saba plus low-medium dose ics in 6 weeks prior to randomisation.
boolean
C0004096 (UMLS CUI [1])
C0205535 (UMLS CUI [2,1])
C2917450 (UMLS CUI [2,2])
C0443303 (UMLS CUI [2,3])
C0205177 (UMLS CUI [2,4])
C2065041 (UMLS CUI [3,1])
C0445550 (UMLS CUI [3,2])
Medical History Consistent with Rhinoconjunctivitis Moderate | Medical History Consistent with Rhinoconjunctivitis Severe | Exposure to Ragweed | Ragweed Seasons Quantity
Item
a reliable history consistent with moderate to severe rhinoconjunctivitis on exposure to ragweed for at least the previous two ragweed seasons.
boolean
C0262926 (UMLS CUI [1,1])
C0332290 (UMLS CUI [1,2])
C0861155 (UMLS CUI [1,3])
C0205081 (UMLS CUI [1,4])
C0262926 (UMLS CUI [2,1])
C0332290 (UMLS CUI [2,2])
C0861155 (UMLS CUI [2,3])
C0205082 (UMLS CUI [2,4])
C0332157 (UMLS CUI [3,1])
C0440357 (UMLS CUI [3,2])
C0440357 (UMLS CUI [4,1])
C0036497 (UMLS CUI [4,2])
C1265611 (UMLS CUI [4,3])
Skin prick test Positive Ragweed
Item
positive skin prick test to ragweed
boolean
C0430561 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
C0440357 (UMLS CUI [1,3])
Ragweed Specific Immunoglobulin E measurement
Item
ragweed-specific immunoglobulin e (ige) ≥ 0.35 ku/l.
boolean
C0440357 (UMLS CUI [1,1])
C0205369 (UMLS CUI [1,2])
C0202086 (UMLS CUI [1,3])
Asthma Life Threatening
Item
history of life-threatening asthma.
boolean
C0004096 (UMLS CUI [1,1])
C2826244 (UMLS CUI [1,2])
Asthma Uncontrolled | Initiative Global Asthma
Item
uncontrolled asthma according to gina
boolean
C0004096 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0424093 (UMLS CUI [2,1])
C2348867 (UMLS CUI [2,2])
C0004096 (UMLS CUI [2,3])
Percent predicted FEV1
Item
fev1 of < 70 % of predicted, regardless of the cause.
boolean
C0730561 (UMLS CUI [1])
Epinephrine Contraindicated | Coronary heart disease Symptomatic | Coronary heart disease Symptomatic chronic | Hypertension, severe
Item
administration of adrenaline (epinephrine) is contraindicated (e.g. subjects with acute or chronic symptomatic coronary heart disease or severe hypertension).
boolean
C0014563 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0010068 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0010068 (UMLS CUI [3,1])
C0231220 (UMLS CUI [3,2])
C0205191 (UMLS CUI [3,3])
C4013784 (UMLS CUI [4])
Drug Allergy Severe | Food anaphylaxis
Item
history of severe drug allergy or anaphylactic reaction to food.
boolean
C0013182 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0685898 (UMLS CUI [2])
Disease Significant | Immune System Disease | Lung disease | Cardiovascular Disease | Gastrointestinal Disease | Liver disease | Kidney Disease | Nervous system disorder | Musculoskeletal Disease | Endocrine System Disease | Metabolic Disease | Malignant disease | Mental disorders | Physical impairment Major | Substance Use Disorders
Item
a history of any significant disease or disorder (e.g. immune system, pulmonary, cardiovascular, gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment, history of alcohol or drug abuse)
boolean
C0012634 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0021053 (UMLS CUI [2])
C0024115 (UMLS CUI [3])
C0007222 (UMLS CUI [4])
C0017178 (UMLS CUI [5])
C0023895 (UMLS CUI [6])
C0022658 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0026857 (UMLS CUI [9])
C0014130 (UMLS CUI [10])
C0025517 (UMLS CUI [11])
C0442867 (UMLS CUI [12])
C0004936 (UMLS CUI [13])
C0231171 (UMLS CUI [14,1])
C0205164 (UMLS CUI [14,2])
C0038586 (UMLS CUI [15])