Diffuse large B-cell lymphoma recurrent | Diffuse large B-cell lymphoma refractory
Item
pathologically confirmed relapsed/ refractory dlbcl
boolean
C0855111 (UMLS CUI [1])
C0855112 (UMLS CUI [2])
First line treatment Previous
Item
must have previously received first line treatment regimen
boolean
C1708063 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Ineligibility Therapeutic procedure High dose | Ineligibility Stem cell transplant
Item
must be ineligible for high dose therapy/ stem cell transplantation
boolean
C1512714 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0444956 (UMLS CUI [1,3])
C1512714 (UMLS CUI [2,1])
C1504389 (UMLS CUI [2,2])
Measurable Disease Site CT scan | Measurable Disease Longest Diameter
Item
measurable disease sites on ct scan (>1.5 cm in longest dimension)
boolean
C1513041 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
C1513041 (UMLS CUI [2,1])
C0552406 (UMLS CUI [2,2])
Prothrombin time assay | International Normalized Ratio | Activated Partial Thromboplastin Time measurement
Item
pt/inr <1.5 x uln and ptt (aptt) <1.5 x uln
boolean
C0033707 (UMLS CUI [1])
C0525032 (UMLS CUI [2])
C0030605 (UMLS CUI [3])
Age
Item
men and women ≥18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog < 2
boolean
C1520224 (UMLS CUI [1])
Liver function | Renal function
Item
adequate hepatic and renal function:
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
1. ast or alt ≤2.5 x uln
boolean
C0201899 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
Estimation of creatinine clearance by Cockcroft-Gault formula | 24 hour renal creatinine clearance
Item
2. creatinine clearance (cockcroft-gault or 24-hour creatinine clearance collection) >60 ml/min.
boolean
C2711451 (UMLS CUI [1])
C4032392 (UMLS CUI [2])
Hematologic function
Item
adequate hematologic function:
boolean
C0221130 (UMLS CUI [1])
Absolute neutrophil count
Item
1. anc >1.50 cells/mm3
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
2. plt >75,000 cells/mm3
boolean
C0032181 (UMLS CUI [1])
Hemoglobin measurement
Item
3. hgb >8.0 g/dl
boolean
C0518015 (UMLS CUI [1])
Central nervous system lymphoma | Leptomeningeal disease
Item
medically apparent central nervous system lymphoma or leptomeningeal disease
boolean
C0280803 (UMLS CUI [1])
C0751297 (UMLS CUI [2])
Allogeneic Stem Cell Transplantation | Organ Transplantation
Item
history of allogeneic stem-cell (or other organ) transplantation
boolean
C2242529 (UMLS CUI [1])
C0029216 (UMLS CUI [2])
Chemotherapy | External Beam Radiation Therapy | Antineoplastic Antibody
Item
any chemotherapy, external beam radiation therapy, or anticancer antibodies within 2 weeks
boolean
C0392920 (UMLS CUI [1])
C1517033 (UMLS CUI [2])
C4329348 (UMLS CUI [3])
Radioimmunoconjugates | Toxin Immunoconjugates
Item
radio- or toxin-immunoconjugates within 10 weeks
boolean
C0243019 (UMLS CUI [1])
C0040549 (UMLS CUI [2,1])
C0243020 (UMLS CUI [2,2])
Study Subject Participation Status | Therapies, Investigational | Ibrutinib | lenalidomide
Item
concurrent enrollment in another therapeutic investigational study or have previously taken ibrutinib and/or lenalidomide.
boolean
C2348568 (UMLS CUI [1])
C0949266 (UMLS CUI [2])
C3501358 (UMLS CUI [3])
C1144149 (UMLS CUI [4])