Pulmonary arterial hypertension | Idiopathic pulmonary hypertension | Pulmonary arterial hypertension Associated with Connective Tissue Disease | Pulmonary arterial hypertension Anorexigenic drug Induced | Familial pulmonary hypertension
Item
patient with known pulmonary arterial hypertension (pah), which has been diagnosed as idiopathic pah, connective tissue disease pah, anorexogen induced or familial pah
boolean
C2973725 (UMLS CUI [1])
C0152171 (UMLS CUI [2])
C2973725 (UMLS CUI [3,1])
C0332281 (UMLS CUI [3,2])
C0009782 (UMLS CUI [3,3])
C2973725 (UMLS CUI [4,1])
C0003620 (UMLS CUI [4,2])
C0205263 (UMLS CUI [4,3])
C0340543 (UMLS CUI [5])
Pulmonary arterial hypertension Evaluation Hemodynamic | Mean pulmonary arterial pressure At rest | Pulmonary Capillary Wedge Pressure | Left ventricular end-diastolic pressure level | Pulmonary Vascular Resistance At rest | Criteria failed | Vasodilator Response Positive
Item
pah diagnosis confirmed by hemodynamic evaluation performed prior to screening and showing all of the following: mean pulmonary artery pressure (mpap) ≥25 mmhg at rest; pulmonary capillary wedge pressure (pcwp) or left ventricular end diastolic pressure (lvedp) ≤15 mmhg; pulmonary vascular resistance (pvr) at rest >3 wood units; not meeting the criteria for a positive vasodilator response (fall in mpap ≥ 10 mmhg to ≤
boolean
C2973725 (UMLS CUI [1,1])
C1261322 (UMLS CUI [1,2])
C0019010 (UMLS CUI [1,3])
C3854605 (UMLS CUI [2,1])
C0443144 (UMLS CUI [2,2])
C0086879 (UMLS CUI [3])
C0456190 (UMLS CUI [4])
C0456261 (UMLS CUI [5,1])
C0443144 (UMLS CUI [5,2])
C0243161 (UMLS CUI [6,1])
C0231175 (UMLS CUI [6,2])
C0042402 (UMLS CUI [7,1])
C1704632 (UMLS CUI [7,2])
C1514241 (UMLS CUI [7,3])
ID.3
Item
40 mmhg).
boolean
WHO classification Functional Status Class
Item
patient with a current diagnosis of who functional class iii
boolean
C4267671 (UMLS CUI [1,1])
C0598463 (UMLS CUI [1,2])
C0456387 (UMLS CUI [1,3])
Pulmonary arterial hypertension | Pharmaceutical Preparations Specific Quantity | Exception Prostaglandins Parenteral
Item
patient should be on two pulmonary arterial hypertension specific medications other than parenteral prostanoids
boolean
C2973725 (UMLS CUI [1])
C0013227 (UMLS CUI [2,1])
C0205369 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0033554 (UMLS CUI [3,2])
C1518896 (UMLS CUI [3,3])
Pharmacotherapy Stable | Drug dosage unchanged | Change of medication Absent
Item
patient is adhering to a stable drug regimen (i.e., with no changes of dose or medication for a minimum of 3 months prior to enrollment)
boolean
C0013216 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0870450 (UMLS CUI [2,1])
C0442739 (UMLS CUI [2,2])
C0580105 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Estimated Glomerular Filtration Rate | Creatinine measurement, serum
Item
patient with egfr levels of ≥ 30 ml/min/1.73m2or serum creatinine levels of ˂
boolean
C3811844 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
ID.8
Item
150µmol/l
boolean
Prostaglandins Parenteral
Item
patient who are treated with parenteral prostanoids
boolean
C0033554 (UMLS CUI [1,1])
C1518896 (UMLS CUI [1,2])
Pregnancy | Pregnancy, Planned
Item
pregnant women or women planning a pregnancy within 12 months of study enrolment
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
Comorbidity Study Subject Participation Status Excluded
Item
patient with significant co-morbid conditions which, at the discretion of the pi, are deemed to prohibit study entry
boolean
C0009488 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
Life Expectancy
Item
patient with life expectancy of less than a year
boolean
C0023671 (UMLS CUI [1])
Study Subject Participation Status | Investigational Medical Device | Investigational New Drugs | Exception Observational Study
Item
concurrent enrollment in another device or drug trial except for observational studies (unless specifically approved by the sponsor)
boolean
C2348568 (UMLS CUI [1])
C2346570 (UMLS CUI [2])
C0013230 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C1518527 (UMLS CUI [4,2])
Pulmonary artery Anatomic structure Excludes Therapeutic procedure
Item
patient with pulmonary artery anatomy that precludes treatment
boolean
C0034052 (UMLS CUI [1,1])
C0700276 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
C0087111 (UMLS CUI [1,4])
Pulmonary artery stenosis Moderate | Pulmonary artery stenosis Severe
Item
patient with moderate to severe pulmonary artery stenosis
boolean
C0238397 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0238397 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Pulmonary artery aneurysm
Item
patient with any pulmonary artery aneurysm
boolean
C0155676 (UMLS CUI [1])
Myocardial Infarction | Angina, Unstable | Cerebrovascular accident
Item
patient who has experienced a myocardial infarction, unstable angina pectoris, or a cerebrovascular accident in the previous 6 months
boolean
C0027051 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0038454 (UMLS CUI [3])