Age
Item
subjects ≥ 18 <75 years of age with any of the following conditions:
boolean
C0001779 (UMLS CUI [1])
Idiopathic pulmonary hypertension
Item
idiopathic primary pulmonary arterial hypertension (ipah)
boolean
C0152171 (UMLS CUI [1])
Pulmonary arterial hypertension Secondary to Connective Tissue Diseases
Item
pah secondary to connective tissue disease
boolean
C2973725 (UMLS CUI [1,1])
C0175668 (UMLS CUI [1,2])
C0009782 (UMLS CUI [1,3])
Pulmonary arterial hypertension | Atrioseptoplasty | Ventricular Septal Defects | Patent ductus arteriosus | Aortopulmonary Septal Defect
Item
pah with surgical repair (at least 5 years previously) of atrial septal defect (asd),ventricular septal defect (vsd), patent ductus arteriosus (pda) and aorto-pulmonary window
boolean
C2973725 (UMLS CUI [1])
C0189965 (UMLS CUI [2])
C0018818 (UMLS CUI [3])
C0013274 (UMLS CUI [4])
C0003516 (UMLS CUI [5])
Pulmonary arterial hypertension | Catheterization of right heart
Item
pah diagnosis confirmed by right heart catheterization performed within 12 months prior to randomization
boolean
C2973725 (UMLS CUI [1])
C0189896 (UMLS CUI [2])
Class Functional | 6-Minute Walk Test Distance
Item
functional class ii-iv; baseline 6mwd ≥ 50 m.
boolean
C0456387 (UMLS CUI [1,1])
C0205245 (UMLS CUI [1,2])
C0430515 (UMLS CUI [2,1])
C0429886 (UMLS CUI [2,2])
Valvular disease Stage | Exception Tricuspid Valve Insufficiency | Exception Pulmonary Valve Insufficiency
Item
significant (ie, >2+) valvular disease other than tricuspid regurgitation or pulmonary regurgitation
boolean
C3258293 (UMLS CUI [1,1])
C1306673 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0040961 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0034088 (UMLS CUI [3,2])
Cardiac Arrest | Respiratory arrest | Collapse Hemodynamic | Cardiopulmonary Resuscitation | Tachycardia, Ventricular | Ventricular Fibrillation | ATRIAL FIBRILLATION UNCONTROLLED
Item
history of cardiac arrest, respiratory arrest, hemodynamic collapse, cpr, ventricular tachycardia, ventricular fibrillation, or uncontrolled atrial fibrillation
boolean
C0018790 (UMLS CUI [1])
C0162297 (UMLS CUI [2])
C0344329 (UMLS CUI [3,1])
C0019010 (UMLS CUI [3,2])
C0007203 (UMLS CUI [4])
C0042514 (UMLS CUI [5])
C0042510 (UMLS CUI [6])
C0741284 (UMLS CUI [7])
Pulmonary Embolism | Chronic lung disease | Restrictive lung disease | Chronic Obstructive Airway Disease | Scleroderma | Pulmonary function impairment
Item
history of pulmonary embolism; history of chronic lung disease / restrictive lung disease (eg, chronic obstructive pulmonary disease (copd) or scleroderma) with impairment of lung function
boolean
C0034065 (UMLS CUI [1])
C0746102 (UMLS CUI [2])
C0085581 (UMLS CUI [3])
C0024117 (UMLS CUI [4])
C0011644 (UMLS CUI [5])
C0858943 (UMLS CUI [6])
Phosphodiesterase 5 inhibitor Long-term
Item
no prior long term treatment with pde-5 inhibitors
boolean
C1318700 (UMLS CUI [1,1])
C0443252 (UMLS CUI [1,2])
bosentan | riociguat
Item
treatment with bosentan or riociguat within 3 months of randomization
boolean
C0252643 (UMLS CUI [1])
C2717561 (UMLS CUI [2])
Nitrates | Nitric Oxide
Item
current treatment with nitrates or nitric oxide
boolean
C0028125 (UMLS CUI [1])
C0028128 (UMLS CUI [2])